<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13232

Description Uncharacterized protein
SequenceMIPHSSAGGQPWGHPLRTFNGGPGWADNAQMLGQYDQLERSASLPQPPIRQPAVVDLTAGGPESQDREPPPKRPRLEVPSGSNTSDTGLAVGETRNTPGSASSRPAVSWRGRPAWSFQAVVSELPSNENRGDGATGSKPPSPPPLPAQPWKNNFVAEPEGSGVVKSRESSPVGAVQTTPYRIEIPSVAPVYKGQKPADFAPWTGNHQEDILSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTTNVQQFIEGVFAAPKSSDWKAKMTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIGTIPVWLLMLGIYWNSIMRYRRRGRRLAELLLQKVRQATEAKLIQLQPLIDRLSRFIKKLVLDHTSSMILPNSWETYKQQVSSTLDLGNEAERALFQSLAERNARVQRPRHSKQTTQRSPHQRIIRLLDSIRSAQDLSSIFGYLDAFDDKAILVFKLLEWLSTPFRHGLCRVYIGVRLLRKWKLAGVDIDSHILAFLSRGHNNQKLNMDQIYHVVSELVRSQTFSVGRYLQWLMARGVTNGSSSAEEHKVKDLPIDIGLIAQLPVARLPEHVGNLRSTLLTRTGLSTSEENAAIDNVKDIISQRLPGIFGVNESTSIALDSLPPNLPWAVKAEVGQWLRRVIAEHNRSAESTNRGAFPVGIASVVSALTPAEFYTVRDALESFGDISMLADVLKFASSCGDSTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGMKRFGMPSLDLIFSLIELGLRIPSELNTVSILRQDLSRMENKSIMAASSPVSDHIPDGFGDVDPLFREKLDQLLQSGSVMDEPTLDAIFNILIKHLESDDGHANLSANDTCRYLAQLRSFHPKHFDGILARWVCGHLRSPERTILLRILPPLIGVGCVTIRAFLALAKRLTLSTPATVPNAAQLPADLVQLLVSDDEDNKSFDLVSYRFQLAQQEFLNKNSEEALKIVCDAASSNADVSSTGHSGLERSIVMLLRDLLVRNPECAAQNGMQKLIDQYPAALSIVQKALDLLLGVESQSDGSSVLSKVEKLACMTDDFSLPFCQLKLQVLFHADSGSEDRTNIVDAMFKTAVSDCRAHRLHWVDLVALMSPDAVRQIRERAEKEFFSIPLLEEPIGDIPDSSDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDSLLHKIITMHNSTLVKGVANTGRSKFERALAFWFSALLRMIVLHRSAFAQPPAALKTNPLHEQLRLLTSIFCIALSRLPGDVIRLFPAADYFPHPTPTEGFRPCPGILLQTHALDVAASLIDVFPDEVRHQCARFLKEKCPSFVPFQNDSRFLYLLGPMTDQFSANAQQVSAPSPAASGSTPTPSPALFSIVGSSPAQQSVAAASGPSTGLPDSNCMANRLRLQHRGRIVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1571
PositionKinase
OrganismPenicillium vulpinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.172
Instability index49.27
Isoelectric point8.50
Molecular weight173063.78
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13232
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.51|      26|      34|     692|     723|       1
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  692-  717 (43.78/17.03)	RLPEHVGNLRSTLLTRTGLSTSEENA
  729-  754 (43.73/23.98)	RLPGIFGVNESTSIALDSLPPNLPWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.03|      31|      74|     848|     879|       2
---------------------------------------------------------------------------
  848-  879 (49.92/35.32)	GATTDLFRRLIDA..YAGmKRFGMPSLDLIFSLI
  923-  955 (50.11/30.44)	GDVDPLFREKLDQllQSG.SVMDEPTLDAIFNIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     214.11|      60|     279|     301|     401|       3
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  256-  298 (55.69/55.75)	AAALEKRQSHNTIHApstFK.PPPRVTLTDNKREAWLRD.......................LANPS...............
  331-  393 (102.81/77.77)	AVWLAKCVGANEIRA...FKRKGTSGALAVGLEAKWVRDWTT...........NVQQFIEGVFAAPKSS.....DWKakmTY
  440-  502 (55.61/16.75)	..........NSIMR...YRRRGRR..LAELLLQK.VRQATEakliqlqplidRLSRFIKKLVLDHTSSmilpnSWE...TY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.96|      33|      36|    1283|    1318|       4
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 1285- 1318 (50.71/31.34)	SSIPDSGAPSVAPVLVEKMDSLLhKIITMHNSTL
 1320- 1352 (52.26/23.21)	KGVANTGRSKFERALAFWFSALL.RMIVLHRSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.48|      24|     279|     301|     325|       6
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  301-  325 (40.47/28.74)	LRRLSRTIPHGIrGKVLLD.QCLGKW
  583-  607 (43.01/25.86)	LEWLSTPFRHGL.CRVYIGvRLLRKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.04|      19|      36|    1144|    1162|       7
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 1144- 1162 (29.34/16.83)	LSIVQKALDLLLGVESQSD
 1182- 1200 (33.70/20.38)	LPFCQLKLQVLFHADSGSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.35|      27|      36|      89|     119|       8
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   89-  115 (49.03/20.41)	LAVGETRNTPGSASSRPAVSWRGRPAW
  124-  150 (50.32/26.02)	LPSNENRGDGATGSKPPSPPPLPAQPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.64|      23|     279|     223|     245|      10
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  223-  245 (39.45/22.91)	RTQVSQ..NESNTARPALYAQLKNR
  503-  527 (33.19/18.18)	KQQVSStlDLGNEAERALFQSLAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.00|      21|      36|     621|     643|      11
---------------------------------------------------------------------------
  621-  643 (31.75/30.70)	FLSRGHNNQKLNMDQiyHVVSEL
  658-  678 (34.25/24.49)	LMARGVTNGSSSAEE..HKVKDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13232 with Med12 domain of Kingdom Fungi
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