<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13229

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMKMLPDRAIPEQWRTFLHQCLANRIDIDEFTDLSGLMFARSPLKENELLDLLLEARASSSVTWDPLLPLYVDGLCKVGRVKSSSALTSLLKHSSVLDVPGSGEREGKAQDSPSKSKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVIEAADIYSATVDWIMAVVAWHNHSLDASQQTGGGLMGSPDAGSLFESLGILLAALSGTNKGLEVLSSDFNQALKTKLGQALSSYLPLCIDVSLPLRHRLEELQKVFNLYPDQPSKTLDGPAIDSVNVNALQFESSVMDGPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYRNESSRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLPGGGPYVKDDLVSQINNNHERAEQLIGEIESMEGNAGAIVCAVVDVMHNLCHQKETMTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCSVLDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISNNDSFILKLLDRGACTQKLSELSEKQNKDLGAWIGALFIAEGISEETMSSCSPHEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESENDPTIPIKTLHSLVKPSSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNQSRTDIKPILDALEPYLSFRRVGSCHRSELDTWTTSAAGGLIGSIRTTLQALVLWSANPEISMAPQAYTHRQVLAGIRMLGATRILGAIIDEVKQQTESGNGHIALDIATTMVCAPMTESFAVDQNNYHPVDTSKESLPRCAILTLRDALALQHENVPKISESDPLRAEVVVRLARRVNMLMAPPSQVSNIDVSNIIQNMHLGVEGQEDRMDLEPSAADVSRNTVNDEESDNINQMLDKAAADAAAGMDGGGMGVGQDMGLDSGAGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1038
PositionTail
OrganismPenicillium vulpinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.068
Instability index46.76
Isoelectric point4.78
Molecular weight113600.27
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13229
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.85|      22|      25|     976|    1000|       1
---------------------------------------------------------------------------
  979- 1000 (40.04/33.33)	M.LDKAAA.DAAAG.MDGGGMGVGQ
 1002- 1026 (25.81/10.47)	MgLDSGAGmDAIDDvLNAADMAVGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.80|      23|      25|     596|     620|       2
---------------------------------------------------------------------------
  598-  620 (38.02/30.35)	TQKLSE..LSEKQNKDLGAWIGALF
  622-  646 (35.79/19.89)	AEGISEetMSSCSPHEFYMLVTTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.27|      10|      19|     260|     269|       4
---------------------------------------------------------------------------
  260-  269 (17.90/ 9.32)	SKTLDGPAID
  280-  289 (18.38/ 9.77)	SSVMDGPVVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.11|      14|      32|     435|     448|       5
---------------------------------------------------------------------------
  435-  448 (27.03/16.85)	EQLLGE.NPMQTLPG
  469-  483 (21.07/11.49)	EQLIGEiESMEGNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.45|      20|      26|     491|     512|       6
---------------------------------------------------------------------------
  491-  512 (31.97/24.98)	DVMhnLCHQKETMTLKNICNSL
  520-  539 (34.48/19.88)	DVM..LLFRTTKQVLQPLCSVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.61|      23|      26|     857|     882|       7
---------------------------------------------------------------------------
  857-  882 (36.69/32.79)	CAPMT..ESFAVDQNNyhpVDTSKESLP
  884-  908 (35.92/21.74)	CAILTlrDALALQHEN...VPKISESDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.21|      17|     228|     732|     748|      14
---------------------------------------------------------------------------
  732-  748 (27.59/19.33)	LEEQLKNVRTRNQSRTD
  756-  772 (30.62/22.29)	LEPYLSFRRVGSCHRSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.76|      14|      19|     922|     935|      15
---------------------------------------------------------------------------
  922-  935 (25.13/14.94)	NMLMAPPSQVSNID
  942-  955 (25.63/15.37)	NMHLGVEGQEDRMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.51|      14|     600|     171|     184|      16
---------------------------------------------------------------------------
  171-  184 (26.30/17.02)	LDA.SQQTGGGLMGS
  773-  787 (20.20/11.18)	LDTwTTSAAGGLIGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13229 with Med5 domain of Kingdom Fungi
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