<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13227

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGITNNPQEGPANGYTILKHLSRLKDLEARLRVLNCLASCPRRLGLWVFSPTPEFESLKPLYLRGSDAESNKIVVGTTTLKVSAFGSVSSLDLVKGLSSDNQSQHGTQPAGQPRPHQSQPSSRRQDGYSSSAAIYASFISAVTGSISLQLIRQHDALPLGSRTLFTAVENSGYESPHVNNENILSTSCLTTLNIQLTMSGTITVSAQTISQTGITRLCSPCKGISEIIDIQPGTDLWLCPNGTIARLVKADIDSPTAPSLGYTAPGNLSAKRIQWKLDVVQWLQNFGLHVDSIDKEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRASSSNFSSVAQNSLLDEPLDFAERWSTMASSLKLDHIAHTTQNTPTTQDLRPKDQEIQSPPKAETLENIESLSRIAQYPDLQSTNLVYPTPPDGAAAVGLNNSNPSDAFAEDSDFGLPHATQRNSRRNAPGSDMSPVQNSGLGVGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMDGESRVEDADLHETLEASHQSESEAEAMVDEEHSLNQPREIPTLVEAHEAHASPIHHEAAQLSEGPMAPEEPAHSPIDRAGQTISPPLSPIEVKKILFPGPEGEDNQQSADNRGQGHYHPVAFKKKLGDWDQKYGATGKFWFSRGGSVDTLDQKSAIPTIGIPHRGRSSANAPGSSKEHNKSLIRSENGLRSASVSSDSSDDSIEIMSEHVTTPAAMPSMPSLKRKRAPSESDIMSVASQEKSLPGTEASPAYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVILRREGQLEIAQLLVDQITQSSLKHPLDGQIGLCDLESQSLSLQILDNTSPLGEASKMDFKTYTSLQDEFVMNHPQQQPPQHPPPPKDTPRSLILKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQAASEAADVFLRRFGLLYQSCSLGTHTRGDDSMAFEDGLKPWQSETSSYESMMQVLKRTCEQLGSELSQSTATADNHVVYIINPFRHAAALADICSAFWHLFQQLIAGSERRQTRIANELVLQIIPLEFIMSSETMVIPPQTDYLNLALEVYSRCRPNDGDMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIACSKSVDQRWISVAWSDLPGSIQRTMSYCLRYRQSGGARPISEVRNEIWATTKHIMDKFQARWKVQLATTEPMETDEAEAWASLADQHNKSKPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAATPTSAGPAAYSAPTPTEMSLETDSEAVLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDADGVFAISVNLIYSPRPPPSHDNVLKDTLSMYRDLGCLARAKGICSVQNNALPWHVATALRAQELLSYVF
Length1477
PositionKinase
OrganismPenicillium vulpinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index60.01
Isoelectric point5.19
Molecular weight161637.07
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13227
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.94|      44|     229|     476|     522|       1
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  477-  522 (74.12/43.67)	AFAED.SDF..............................GLPHaTQRNSrRNAPGS....DMSPVQN.SGLGVGTGRYDASD
  678-  757 (42.82/14.85)	AFKKKlGDWdqkygatgkfwfsrggsvdtldqksaiptiGIPH.RGRSS.ANAPGSskehNKSLIRSeNGLRSASVSSDSSD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     443.79|     148|     531|     226|     431|       2
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  226-  430 (210.13/246.21)	MSGTITVSAQTISQTGITRLCSPCKgiSEIIDIQ......PGTD...LWLCPNGTIARLVKADIDSPTApsLGYTA...PGNLSA.KRIQWKLDVVQWLqnfglhVDSIdkepwvevevwepffarlageawrqsddSQSAL..PLKRMLwpaRFCFRRASSSNFSSVAQNSLLDE..PLDFaERWSTMASSLKLDHiahttqntpttqdlrPKDQEIQSPP
  763-  927 (233.66/146.06)	MSEHVTTPAAMPSMPSLKRKRAPSE..SDIMSVAsqekslPGTEaspAYAAENSTFLGNFLANFSDWTL..TGYFSafpPQQLPViLRREGQLEIAQLL......VDQI............................TQSSLkhPLDGQI...GLCDLESQSLSLQILDNTSPLGEasKMDF.KTYTSLQDEFVMNH...............PQQQPPQHPP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.20|      69|     935|      21|      98|       3
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   21-   98 (107.30/85.01)	YWRIYteeaGItnNPQEGPAN..GYTILKHLSRlKDLEARLRVLNCL.ASCprRLGLWVF.SPTPEFE.SLKPLYLRGSDAES
  963- 1036 (110.90/64.23)	FWETF....GL..EPAHGPKNisAYCIHPQAAS.EAADVFLRRFGLLyQSC..SLGTHTRgDDSMAFEdGLKPWQSETSSYES
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.11|      19|      31|     580|     598|       5
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  580-  598 (32.02/17.97)	EAEAMVDEEHSLNQPREIP
  614-  632 (33.10/18.85)	EAAQLSEGPMAPEEPAHSP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.54|      10|     862|     538|     547|       6
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  538-  547 (19.97/13.11)	KGITDADFSF
 1403- 1412 (19.58/12.69)	KGATDADGVF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.26|      29|     870|     437|     466|       8
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  437-  466 (48.67/30.11)	NIESLSRIAQYPD........LQSTNLVYPTPPdGAAA
 1310- 1346 (44.59/22.87)	NILSSSTPVSTPNpsasvaspEQSGNAATPTSA.GPAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13227 with Med13 domain of Kingdom Fungi
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