<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13226
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MELGPFISTRKLSLSQEHNPTMNALVQSALTDVESKLNALLTSLTTSPTAAGAPAAAVALLDADDALTSAIESLRQHQENYAKILRLRTEAQQLEDRVKGIVGDIEGFEKEIRTACGDNGDSDSDFDSDSDSDDDLGGEKSVLRGIKEIDYRLLLDFARRISKYNHEAAADAATGVVKRPEHGNAPADKDVAMTGTNGEHPTEEGAEPVASVTKNATQWLDESANVTRQVYMLPYPMEERIRMGLMGQIQLAAGDDPEKEVERLIREAEGLGAAEPPAPMAPAESTKQAGEAAKAAAQAGSSAAGMPRAHAQAPAPKPKPKAMLDLDLYDPDEDDD |
Length | 336 |
Position | Middle |
Organism | Penicillium vulpinum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.552 |
Instability index | 42.54 |
Isoelectric point | 4.55 |
Molecular weight | 35857.34 |
Publications | PubMed=28368369
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13226
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 124.97| 38| 125| 167| 204| 1
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167- 204 (67.18/35.64) EAAADAATGVVKRPE.HGNAPA..DKDVAMTGTNGEHPTEE
294- 334 (57.79/29.66) KAAAQAGSSAAGMPRaHAQAPApkPKPKAMLDLDLYDPDED
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 102.57| 34| 151| 52| 117| 2
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52- 85 (54.46/71.37) GAPAAAV.ALLDADDALTSAIESLRQHQE.NYAKIL
120- 155 (48.12/15.02) GDSDSDFdSDSDSDDDLGGEKSVLRGIKEiDYRLLL
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|