Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MGENATSEELPSFTSADRIRQLNEMDKDVTKLLNSAGLAIQALTNAKPDSSVASDGSLDSHKTRFKEASAKYFALLSSADVTLRRQIYSLEESSLVGPEKASRAGDTKAAARGEGVTVAKSRAPNSLDISRLNSRKDTVGKDKEAELWAAARKFIEEMQKSSETSKDSRPANEPEDMQVD |
Length | 180 |
Position | Head |
Organism | Penicillium vulpinum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.733 |
Instability index | 38.29 |
Isoelectric point | 5.42 |
Molecular weight | 19525.40 |
Publications | PubMed=28368369 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13222 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 88.52| 28| 38| 109| 137| 1 --------------------------------------------------------------------------- 109- 137 (41.06/28.69) AAARGEGVTVAKSrAPNSLDISRLNSRKD 149- 176 (47.46/28.78) AAARKFIEEMQKS.SETSKDSRPANEPED --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DRIRQL 2) LDISRLNSRKDTVGKDKEAELWAAARKFIEEMQKSS 3) LRRQIYSL | 17 127 83 | 22 162 90 |
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