<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13218

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFTLPLRPIPEKRDRPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKYGLDEVDESDQDASDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESKTKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKVSRLPSEKQSLGVQYGFLEATPVFRDCGLASLRRAEDGALLLDEGLIPSKARFVRVRVIQNGRLSGSSKPTRSTFNGNETIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDDLEILLDLVDTDEDTPEPEHDISQQGTSLAEGLAHTIRILLAYAHRQNLRRRTLLPLPLTPKTRPVPEHQLLRPALAYIKHMSHVRWLQSLLKDLFGVLQSAGLKPPAYTSRVFSTARRRQTSPTPEVEALVDQFLTPLLSTFNGKILTPLGSFSIAIHTNLSSPPFGTSFDVSFNMPKYPDFESPGKLSHREEVEAAITHLLLLDVVFAVSSNSNLPQPESDKDQAKRTWEAVYPQHGELLIPSKSEKRKKMKIALSRHELSLEIYAVRCIDGTGRGHWELPAYHSMPHTWKPSPIAGSPKQSSLMDYVSTNVSRS
Length643
PositionHead
OrganismPenicillium solitum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.447
Instability index54.67
Isoelectric point6.20
Molecular weight72262.07
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13218
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.43|      35|      39|     469|     507|       1
---------------------------------------------------------------------------
  469-  507 (51.72/46.07)	FN..GKiLTPLGSFSIAI.HTNLSSPPFGTSFDVsfNMPKyP
  509-  546 (50.71/29.68)	FEspGK.LSHREEVEAAItHLLLLDVVFAVSSNS..NLPQ.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.06|      45|      46|     319|     364|       2
---------------------------------------------------------------------------
  319-  364 (70.40/53.96)	LIQIPASDDL..EILLDLVDTDEDTPEPEHDISQQGTSLAEGLAHtIR
  366-  412 (73.66/51.65)	LLAYAHRQNLrrRTLLPLPLTPKTRPVPEHQLLRPALAYIKHMSH.VR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.74|      17|     417|     199|     215|       3
---------------------------------------------------------------------------
  199-  215 (32.12/19.28)	WKVSRLP.SEKQSLGVQY
  618-  635 (29.62/17.22)	WKPSPIAgSPKQSSLMDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13218 with Med17 domain of Kingdom Fungi
Unable to open file!