<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13218
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MADSFTLPLRPIPEKRDRPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKYGLDEVDESDQDASDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESKTKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKVSRLPSEKQSLGVQYGFLEATPVFRDCGLASLRRAEDGALLLDEGLIPSKARFVRVRVIQNGRLSGSSKPTRSTFNGNETIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDDLEILLDLVDTDEDTPEPEHDISQQGTSLAEGLAHTIRILLAYAHRQNLRRRTLLPLPLTPKTRPVPEHQLLRPALAYIKHMSHVRWLQSLLKDLFGVLQSAGLKPPAYTSRVFSTARRRQTSPTPEVEALVDQFLTPLLSTFNGKILTPLGSFSIAIHTNLSSPPFGTSFDVSFNMPKYPDFESPGKLSHREEVEAAITHLLLLDVVFAVSSNSNLPQPESDKDQAKRTWEAVYPQHGELLIPSKSEKRKKMKIALSRHELSLEIYAVRCIDGTGRGHWELPAYHSMPHTWKPSPIAGSPKQSSLMDYVSTNVSRS |
Length | 643 |
Position | Head |
Organism | Penicillium solitum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.447 |
Instability index | 54.67 |
Isoelectric point | 6.20 |
Molecular weight | 72262.07 |
Publications | PubMed=28368369
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13218
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 102.43| 35| 39| 469| 507| 1
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469- 507 (51.72/46.07) FN..GKiLTPLGSFSIAI.HTNLSSPPFGTSFDVsfNMPKyP
509- 546 (50.71/29.68) FEspGK.LSHREEVEAAItHLLLLDVVFAVSSNS..NLPQ.P
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 144.06| 45| 46| 319| 364| 2
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319- 364 (70.40/53.96) LIQIPASDDL..EILLDLVDTDEDTPEPEHDISQQGTSLAEGLAHtIR
366- 412 (73.66/51.65) LLAYAHRQNLrrRTLLPLPLTPKTRPVPEHQLLRPALAYIKHMSH.VR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.74| 17| 417| 199| 215| 3
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199- 215 (32.12/19.28) WKVSRLP.SEKQSLGVQY
618- 635 (29.62/17.22) WKPSPIAgSPKQSSLMDY
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