<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13217

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGITSNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLKPLYVRGSDAESNRIVVGTTTLKVSALGSVSSLDLVKGLSSDNQSQHGTQPTGQPRPHQGQPSPRRQDGYSSSAAIYASFISAVTGSIGLQLIRRHAALPLGSRTLFTAVEKSGYESPHINNDNILSTSCLTTLNIQLTMSGTITVSAQTISQAGISRLCSPHEDISERIDVQPEIDLWLCPNGTIAKLVTANIDSSTLSSLSYPAPGNLSAKRIQWKLDVVRWLRNFGLHVGSIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRASSSNFSSGTQASLLDEPLDFAERWSTMASSLKLDDISHTAQNTPITQDPQPKDQEMPSPLKPEPLESIESLSRIAQYPDLQSTNLVYPTPPDGTAAVGLSNPNPSEAFADDFDFGLPHTTQRNSRRNAPGSDISPVQNSGVGVGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGNSLVEDADEALEAPHPPSELEAEAMVDAEPSPNQQQEIPIHVETHEAHASPIYDEAPRLSEEPMAPEEPAHSPVDRAAQTISPPLSPVEVKKILFPGPKADNHQQSTDNRGQGHYHPVEFEKKLGDWDRKYGAAGKFWFSGGGSLDTLNQTSAIPTIGMPHRGRSSANAPGSSKEYNKPSLSLTQSENGLRSASVSSDGSDDSIEIMSEHVPTPAAASSIPSLKRKRAPSESDIISIASQEKSLPVTEASPTYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLFRREGQLEIAQLLVDQITQSSLKHPLDGQIGLFDLESESLSLQALDDTTLLGETSKMDFKRYTSLQDEFVANQPQQQPPQHPPPPKETPKSFISKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQAASKAADVFLTRFGLLYQSCSLGTHTRGDDSVAFEDGLRPWKSETSSYESMMQVLKRTCEQLGSELSQSPATADNNVVYIINPFTHAAALADICSAFWHLFQQLVAGSERRQTRISNELVLQIIPLEFVMSSETMVVPPETDYLNLALEVYSRCRPNDADMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDLSGSIQRTMSYCLRYRQSSGARPVSEVRNEIWATTKHIMDKFQARWKVQLVTTEPIETDEVEAWASLADQHNKLRPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAATPTSAGPAAYNAPTPTEMSLETDSEAILTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFAISVNLIYSPHPPPSHDNVLKDTLSMYRDLGCLARAKGICSVQNNTLPWHVATALRGQELLSYVF
Length1479
PositionKinase
OrganismPenicillium solitum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.392
Instability index60.00
Isoelectric point5.05
Molecular weight161867.09
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13217
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1259.07|     336|     351|     332|     682|       1
---------------------------------------------------------------------------
   79-  342 (299.05/142.46)	.........................................................................................PTP.eFESLKPL.............YV.RGSDAESNRIVVGTTTLKVSALgsvssldlvkGLSSDNQSQHGTQPTGQPRPHQGQPSPRRQDGYSSSAAI...YASFISAVTG........SIGLQLIRRHAALPLGSRTLfTAVEKSGYESPHIN......NDN...ILSTS...CLTTLNI.......QLTM.SGTITVSAQTISQAGISRLCSPHE.D..ISERIDVQPEI.DLWLCPNGTIAKLV..TANIDSSTLSSLSYPA.....PGNlSAKRIQWKLDVvrwlRNFGlHVGSIDEEPwvEVevWEPFFArLAGE
  343-  694 (557.15/294.83)	AWRQSDDSQSALPLKRMLwPARFCFRRASSSNFSSGTQASlLDEPldfaerwstmasSLKLDDISHTAQNTPITQDPQPKDQEMPSPLKPEP..LESIESLSR...........IA.QYPDLQSTNLVYPTPPDGTAAV..........GLSNPNPSEAFADDFDFGLPHTTQRNSRRNAPGSDISPV...QNSGVGVGTGRYD....ASDEEDLFGEMNERDFGSKGI.TDADFSFFDDPDFDG....MEGN...SLVED...ADEALEAP..HPPSELEA.EAMVDAEPSPNQQQEIPIHVETHEAH..ASPIYDEAPRLSEEPMAPEEPAHSPVDRAAQTISPPLSPVEVKKIL..FPGP.KADNHQQSTDN....RGQG.HYHPVEFEK..KLgdWDRKYG.AAGK
  695- 1026 (402.87/194.01)	FWFSGGGSLDTLNQTSAI.PTIGMPHRGRSSANAPGSSKE.YNKP............SLSLTQSENGLRSASVSSDGSDDSIEIMSEHVPTPaaASSIPSLKRkrapsesdiisIAsQEKSLPVTE.ASPT...................YAAENST..FLGNFLANFSDWTLTGYFSAFPPQQL.PVlfrREGQLEIAQLLVDqitqSSLKHPLDGQIGLFDLESESL.S...LQALDDTTLLGetskMDFKrytSL.QDefvANQPQQQPpqHPPPPKETpKSFISKLSAPH......IRVRRGKEYleALP.....PAVSFWETFGLEPAHGPKNISAYCIHPQAASKAADVFLtrF.GL.LYQSCSLGTHT....RGD....DSVAFED..GL.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.85|      25|    1380|      35|      66|       2
---------------------------------------------------------------------------
   35-   66 (38.33/44.05)	PQESPAngytilkHLSRLKDLEARLRGLNCLA
 1424- 1448 (49.52/36.01)	PHPPPS.......HDNVLKDTLSMYRDLGCLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13217 with Med13 domain of Kingdom Fungi
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