<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13214

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSGHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQQQTQQPTQHRPTDHDRQSLQTESTNDFATGQGQHSTDPDAMDVDTEPTRRADTLSLDLDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGSIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEIGAPGSLRYMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKAAPAPAAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMFGIGAR
Length458
PositionHead
OrganismPenicillium solitum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.958
Instability index57.61
Isoelectric point6.44
Molecular weight49391.68
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13214
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.17|      26|      27|      14|      39|       1
---------------------------------------------------------------------------
   14-   39 (50.47/31.39)	PPSPSSPA.GSLKE.NHRLPISSEHI.P.Q
   41-   67 (21.05/ 7.90)	...PTSPPlMSVNEqSHAANFTSSHTsPnQ
   72-   90 (36.65/20.36)	PPNISSPP.SS.......APMSTQ.V.S.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.03|      13|      15|     395|     407|       2
---------------------------------------------------------------------------
  395-  407 (26.21/14.57)	NYDDNSFAGYGEG
  411-  423 (26.82/15.06)	DDDDPGFYSNGEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.08|      18|      21|     155|     172|       3
---------------------------------------------------------------------------
  155-  172 (31.95/23.22)	TDHDRQSLQTESTNDFAT
  179-  196 (30.34/21.64)	TDPDAMDVDTEPTRRADT
  197-  212 (18.78/10.29)	LSLDLDSLQKELTSAF..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.06|      17|      21|     352|     368|       4
---------------------------------------------------------------------------
  352-  368 (29.55/16.36)	APGETGKKAAPAPAAGR
  376-  392 (30.51/17.16)	ASPRSQEAERPRPSRGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.56|      19|      19|     263|     281|       5
---------------------------------------------------------------------------
  263-  281 (31.80/19.08)	GKLKGLGLAGRNKPHKQEI
  285-  303 (35.76/22.28)	GSLRYMTLWPEEEWQNQKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.21|      20|      27|     104|     123|       6
---------------------------------------------------------------------------
  104-  123 (33.28/17.57)	ASSVSGHPANATSEDVDQGR
  134-  153 (34.93/18.81)	AENSGAAPAQQQTQQPTQHR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13214 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRTHPTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSGHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQQQTQQPTQHRPTDHDRQSLQTESTNDFATGQGQHSTDPDAMDVDTEPTRRADTLSLDLD
2) NQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKAAPAPAAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMF
1
300
202
453










Molecular Recognition Features






MoRF SequenceStartStop




1) DDPGFY
2) DWWEDILGHE
3) GEGFV
4) KKKRKKDHVAKVST
413
336
405
426
418
345
409
439