<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13210

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNVNIEGSVRRPGLNEARNGAPNVFGTTDKSVQSSGMNGSVYLNGASSGIAASNQHPSTLVDKAEETVPTTPFILPHITQGFFPFGTLVNRSVQECWNELSELITELATIQVPASGGSMPTNGKPTGNQSSENVHKKLRFLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTAVEVLSKGRVASLPDLGYKPPTPLTARLTLKKLLKLNRIISVRLALHDSVPPPLRNYRVHDGRVTFTISGEFELDLSVAEESKASQFFFVDIRFLFSPSSPIPKGRIFNELDGKINDLLRDDGLMGCFQFLHGLVLTNKINILFKQAVDLSRGLWADALRIELLHRTLVVQYWPQRSGPKSWLEIGVKSGHYGGSCSDPKPGISHIGFRWMRDGQQVSSDPIRFSPGDLSMELILRSVIALHVSHLLSTAFTTLKKHTLFSNHTLSLQAQLSPTEPGDCRLDVQLTGSRSLRVSIEPMSGSITLCGTPHVLERLDGDRGLYKSSIEEILSRVARLRCIIAVDEIDSATKALGLESVNQRVLGVDPRKLFPPGVMRTAFFTHRLWNRHWVAAATSSMDGDRWWLVQLRPTEAAKMGPFYSIGDHGVSVPQVHVVSEALVSPQRRLNYTTCAELVHGLTGILTIHANARYLADLPAMHFWPSLKELQLEKDLTVPDLLFNYSSSTLPPVFRVTLPFGVKKQSQFKEMIRLAFHGIDSQSRSVIMMAHGTLKTRIKSLVPLVSKMDSSLIIEDKGAGFALRLLVPAGHSVVACLFELLQRLECVLSILQSLIRKGMEPQSLSLSRIDFAYGPENKFSAFFDISAEGPSLSDYVDVADAISKNKPLFQLKLGIKFESSSPHRRIQEPLTVALNQRFTEAGVESTLQLLATTLPLLRSLDQITPQSSQTDLSIVQIIVRKPTVYLIHYPQLRSRFHLSAVMHQDRLVWMLRDANGMDQSGRAQVAAFIQEKLYQSKGDGWNGLGDGAVASINKVGNLILELHEYLNAPHLQLDKGVEAKSEQIPKQLHIQSSTSAPPQARGSTDVITID
Length1080
PositionTail
OrganismPenicillium vulpinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.110
Instability index51.24
Isoelectric point9.12
Molecular weight119540.04
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13210
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     454.90|     100|     235|     655|     754|       1
---------------------------------------------------------------------------
  655-  738 (125.68/69.67)	........................SP.......QRRLNYTTCAELVHGL.TG.ILTIHAN.ARYLA.DL..PAMH.FWPSLKEL..QLEKDL.....TVPDLLFNYSSSTL..PP....VFRVTLPF.GVKKQSQF
  739-  849 (110.10/60.16)	KEMIRLAFHGIDSQSRsvimmahgTL.......KTRIK..SLVPLVSKM.DS.SLIIEDKgAGFAL.RLlvPAGHsVVACLFELlqRLECVL.....SILQSLIR...KGM..EPqslsLSRIDFAY.G..PENKF
  876-  977 (126.65/70.27)	KPLFQLKL.GIKFESS........SP.......HRRIQEPLTVALNQRF.TE.A.GVEST.LQLLAtTL..PLLR.SLDQITPQ..SSQTDL.....SIVQIIVRKPTVYLihYP....QLRSRFHLsAVMHQDRL
  978- 1071 (92.48/49.38)	VWMLRDA.NGMDQSGR..........aqvaafiQEKL.YQSKGDGWNGLgDGaVASINKV.GNLIL.EL.....H.EYLNAPHL..QLDKGVeakseQIPKQLHIQSSTSA..PP....QAR..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.04|      19|      49|     442|     460|       2
---------------------------------------------------------------------------
  442-  460 (32.13/19.91)	PGDLSMELILRSVIALHVS
  492-  510 (33.91/21.41)	PGDCRLDVQLTGSRSLRVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.96|      58|     223|     149|     206|       3
---------------------------------------------------------------------------
  149-  206 (97.44/61.68)	FAHAKRAEFI.KLLVLSQWSRQAADVSRL.IDIQ.GFIRTRHQSYDAALQYVG........EVKRDLVR
  371-  439 (83.52/51.79)	WADALRIELLhRTLVVQYWPQRSGPKSWLeIGVKsGHYGGSCSDPKPGISHIGfrwmrdgqQVSSDPIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.62|      18|     495|      88|     133|       4
---------------------------------------------------------------------------
   38-   55 (31.75/48.01)	VQSSGMNGSVYLNGASSG
  116-  133 (33.87/ 7.09)	IQVPASGGSMPTNGKPTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13210 with Med14 domain of Kingdom Fungi
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