<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13209

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDGINVDDLFGEPNSLELGLPAASPIKGLAQCLDEMRLLGCCQKIAWSRMGCIASISPDGLRVIVRHLQCHPSDGKWVLGEESSLAPVLEAHNGNQLAHLSWNETGSELAVVDCSGRISIYSISIAVNSITGLRQASFDSGDDGSQVVGMMWLNSQRYVHAFHQAARVNGRWAYSPFRRRPVGPFQPANKGALICVTRAGQIKLIYQNPDSKWAELPAELKNTGYSDRLLTHASMTATQAGILLSTYSACQKMCLYRVHISWNPSQWEPAQGKPPGQFPIPTFRLIHCKVDMPSNILNINRGPDHSDQSLPFLNSVYSLTRLEIMPGQFDSPAGSTANPWILAVLSKPLHAIHDYPDQQGPPSVIVRWHLESAPQILHPKFDEVTSKKSNAQAKPKMELRRLEDVYCDKYIVSVDLVEHGTVLAVSHDDSSITCYDTRTMTVLNGLDDSTTVTCLAQAGFQYPLETSGLHIAFSPNACVAVTLDIDGHMQLRVMEHSFGSTEGLYDENNFSAAIAALTLAFSRGCGVDYNTDDILVVALGQLSPGEYSEDLRSNITKTLTTSKEAQTTFISEVYRALPVNCNFTAEQDKLMSHPYIPRCLSLQAGLGFKGRLKQRNLSSAVPWASLQLRHASVLFAYFFQYNKGGQTESHDPDVLRMVLGNTKWTLDFSHFLLNEIFDLADEFEDVYHDPEAFTQKLKNSSSLPLLILLSSMSRAFLRFICRGLRGVHAGFASANPASLVGDSRIYYTEICQTLESSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAERPGPEKELLVNARIPPVLTTAVATLLRQTVPALKSEINRRAIYLGDYSWLGFGNDRRTALYRKQREVDILKKCPLRPPLPLGNDGRVAPLKKRRCARCCEVSGDTNLPRSLLSFKMIAKLGLLRSCLCGGMWVLETDTGDLGARTASTNGSSNRVSQA
Length947
PositionTail
OrganismPenicillium solitum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.179
Instability index43.52
Isoelectric point6.81
Molecular weight104374.82
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13209
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.75|      17|      37|     467|     484|       1
---------------------------------------------------------------------------
  467-  484 (26.66/22.20)	TSGLH..IAFSpNACVAVTL
  502-  520 (25.09/14.75)	TEGLYdeNNFS.AAIAALTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.22|      34|      37|     627|     662|       2
---------------------------------------------------------------------------
  627-  662 (55.38/45.71)	LQLRHasVLFAYFFQYNKGGQTESHDPDVLRMVLGN
  667-  700 (58.84/41.94)	LDFSH..FLLNEIFDLADEFEDVYHDPEAFTQKLKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.34|      32|      38|     170|     201|       3
---------------------------------------------------------------------------
  170-  201 (58.63/37.65)	NGRW...AYSPFRRRPVGPFQPANKGALICVTRAG
  211-  242 (53.20/33.45)	DSKW...AELPAELKNTGYSDRLLTHASMTATQAG
  260-  279 (19.51/ 7.40)	HISWnpsQWEPAQGKPPGQF...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.89|      16|      26|     839|     854|       4
---------------------------------------------------------------------------
  839-  854 (30.15/18.53)	LGFGNDRRTALYRKQR
  868-  883 (29.74/18.18)	LPLGNDGRVAPLKKRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.65|      28|      38|     325|     352|       5
---------------------------------------------------------------------------
  292-  307 (22.61/ 8.79)	......DMPSN......ILNINRGPDHS
  325-  352 (51.00/28.59)	IMPGQFDSPAGSTANPWILAVLSKPLHA
  355-  379 (42.03/22.33)	DYPDQQGPP..SVIVRWHLESAPQILH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.43|      26|      26|     570|     595|       6
---------------------------------------------------------------------------
  549-  568 (23.20/ 9.30)	...SEDLRS...NITKTL..TTSKEAQT
  569-  594 (44.23/23.30)	TFISEVYRALPVNCNFTA..EQDKLMSH
  595-  621 (36.00/17.83)	PYIPRCL.SLQAGLGFKGrlKQRNLSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      12|      27|     714|     725|       7
---------------------------------------------------------------------------
  714-  725 (22.44/13.77)	SRAFLRFICRGL
  744-  755 (22.75/14.05)	SRIYYTEICQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      14|      19|     422|     435|       8
---------------------------------------------------------------------------
  422-  435 (24.99/15.93)	TVLAVSHDDSSITC
  442-  455 (25.10/16.03)	TVLNGLDDSTTVTC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13209 with Med16 domain of Kingdom Fungi
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