<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13206

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFTLPLRPIHEKRERPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKDGMDEVDESGQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQSPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESTTKDIAAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKNKGWKISRLPREKQALGVQYGFLEATPVFRDRGLASLRRAEDGALLLDEGLIPSKARYVRVRVIQDGRLTGSSKPTRSSLDGDRTIEDRILQARDTVYEEELFHELVREARAIASLGVTTRQNLIQIPASDDLEVLLDLVDTDENTLQPEHDITQQGTSLAEGLAHTIRILLAYAHRQNLRRRTLLPPPLTPKTRSIPEQQLIRPALAYIKHMSHVRWLQSLLKDLFGVLQSADLELPAYTTRVFSTVRQRQTSPDPKVETLVGQFLTPLLSTFNGKILTPRGSFSIAIHTNLSSPPFGTTFDVSFNMPKYSDLQSPGKISHRDDVEAAITHLLLLDVVFTISSKSSPRSDRDQVKRTWEAIYPQHGELLLSPSKSEKRKKMKIALSRHELSLEIYTVRCIDGTGRGKCEHPSYHSVPHTWKPSIAGSPNQPSLMDFVSKV
Length636
PositionHead
OrganismPenicillium vulpinum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.460
Instability index50.45
Isoelectric point7.00
Molecular weight71651.56
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13206
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.78|      38|      39|     436|     473|       1
---------------------------------------------------------------------------
  436-  473 (65.81/40.31)	TTR.VFSTVRQRQTSPDPKVETLVGQFLTPLLSTFN..GKI
  475-  515 (59.96/36.10)	TPRgSFSIAIHTNLSSPPFGTTFDVSFNMPKYSDLQspGKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.46|      32|      34|     348|     381|       2
---------------------------------------------------------------------------
  348-  381 (49.11/41.58)	ITQQGTSLAEglAHTIRILLAY.AHRQNLRR.RTLL
  385-  418 (49.34/34.46)	LTPKTRSIPE..QQLIRPALAYiKHMSHVRWlQSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.06|      24|      27|     195|     218|       3
---------------------------------------------------------------------------
  156-  171 (22.03/11.79)	..RGWRIQNFNA.AANKL......L
  195-  218 (42.35/29.44)	KNKGWKISRLPR.EKQALGVQYGFL
  225-  247 (29.68/18.43)	RDRG..LASLRRaEDGALLLDEGLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13206 with Med17 domain of Kingdom Fungi
Unable to open file!