<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13198

Description Uncharacterized protein
SequenceMIPHSSAGGQSWGHPLRTFNGGPGRVDNAQMLGQYDQPDRSASLPQPPIRQPVVVDLTAGGPESQDREPPPKRPRLDVPSASHTSETGAAGGETRSTPGSAISRPAVSWRGRPAWSFQAVVSELPSNENRGDGAAGSKPPSPPPLPAQPWMNNFVAEPEGSGVVKSRESSPVGAVQTTPYRIEIPSVAPVYKGQKPADFAPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKILLDQCLGKWIPIARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTTNVQQFVEGVFAAPKSSDWKAKVTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIGTIPVWLLMLGIYWNSIMRYRRRGRRLAELLLQKVQQATEAKLTQLQPLIDRLSRFIKKLVLGHTSSMILPNSWGTYQQQVSSALDLGNEAEKALFQSLAERNARVQRPRHSKQTTQRSPHQRIVRLLDSIHSAQDLSSVFSYLDAFDDKAVLVFKLLEWLSTPFRHGLCRVYIGVRLLRKWKSAGVDIDSHILAFLSRGQTNQKLNMDQIYHVVSELVRSQTFSVGRYLQWLMARGVTNGSSSAEERKVKDLPIDIGLIAQLPVARLPEHVGNLRSTLLTRTGLSPSDENAAIDSVKEIISQRLPGIFGVHESTSMALDSLPPNLPWAVKAEVGQWLRRAIAEHNRSAESTNRGAFPVGFASVVSALTPSEFYIVRDALESFGDISMLADVLKFASSCGDSTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGIKRFGMPSLDLIFSLIELGLRIPSDLNTVSILRQDLSRMENKAIMAASSPVSDHIPDGFGGVDPFFREKLDQLLQSGNVMDEPTLDAIFNTLIKHLESDDGHANLSANDTCRYLAQLRSFHPKHFDGILARWVCGHLRSPERTILLRILPPLIGVGCVTIRAFLALAKKLTLSKPVTVPNAAQLPADLVQLLVSGEEDSKSFDLVSYRFQLAQQEFLNKNSEEALKIVCDAASSNAGSSSTGHTEMERSIVMLLRDLLVRHPECAAQNGMQKLMDQYPAALSIVQKALDLLLGIESQSDGSSVLSKVEKLACMTDDFSLPFCQLKLQVLFHADSGSEDRTNIVDAMFKTAVSDCRAHRLHWVDLVALMSPDAVRQIRERAEKEFFSIPLLEEPIGDIPDSPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDSLLHKIITIHNSTLAKGVANTDRSKCERALAFWFSALLRIIVLHRSAFSQPPPALKINPLHEQLRLLTSIFCIALSRLPGDVLRLFPAADYFPHPTPTEGFRPCPGILLQTHALDVAASLIDIFPDEVRHQCARFLKEKCPSFVPFQNDSRFLYLLGPISDQYPANAQQASAPSPAASGSTPTSTPALFSMVGSSTAQQSVTAASGPSTAPPDSNSMANRLRLQHRGRVIGPYPVRPWELLEDAAPFLGINDTAVNLGFFDARRVRA
Length1571
PositionKinase
OrganismPenicillium solitum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.176
Instability index48.69
Isoelectric point8.62
Molecular weight172691.28
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13198
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.46|      33|      35|    1283|    1316|       1
---------------------------------------------------------------------------
 1283- 1316 (49.29/36.41)	LASSIPDSGAPSVAPVLVEKMDSLLhKIITIHNS
 1318- 1350 (55.17/35.61)	LAKGVANTDRSKCERALAFWFSALL.RIIVLHRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.25|      33|      37|    1449|    1484|       2
---------------------------------------------------------------------------
 1449- 1484 (51.06/37.19)	PFQNDSRFlYLLGPISDQYPANAqqASAPSPAASGS
 1486- 1518 (58.19/32.21)	PTSTPALF.SMVGSSTAQQSVTA..ASGPSTAPPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.50|      21|      37|     692|     712|       3
---------------------------------------------------------------------------
  692-  712 (37.62/22.99)	RLPEHVGNLRSTLLTRTGLSP
  729-  749 (35.49/21.25)	RLPGIFGVHESTSMALDSLPP
  766-  783 (29.39/16.25)	AIAEH..N.RSAESTNRGAFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.27|      21|      37|     356|     376|       4
---------------------------------------------------------------------------
  356-  376 (37.49/21.53)	AVGLEAKWVRDWTTNVQQFVE
  394-  414 (33.78/18.68)	AVGLTARLFSENLLDHDHFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.14|      38|      38|     591|     628|       5
---------------------------------------------------------------------------
  550-  589 (19.67/ 9.81)	..........V.RLLDSIHSAQdlssvfsyLDAfdDKAVLVFklLEWLSTP
  591-  628 (66.58/56.70)	RHGLCRVYIGV.RLLRKWKSAG........VDI..DSHILAF..LSRGQTN
  630-  665 (52.89/43.02)	KLNMDQIYHVVsELVR...SQT........FSV..GRYLQWL..MARGVTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.42|      27|      37|    1134|    1166|       6
---------------------------------------------------------------------------
 1134- 1162 (39.22/35.57)	QKL...MDQYpaALSIVQKALDLLLGIESQSD
 1171- 1200 (42.20/20.96)	EKLacmTDDF..SLPFCQLKLQVLFHADSGSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.85|      17|      38|      93|     109|       7
---------------------------------------------------------------------------
   93-  109 (32.36/14.15)	ETR......STPGSAISRPAVSW
  128-  150 (30.50/12.91)	ENRgdgaagSKPPSPPPLPAQPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      13|      15|     309|     323|       8
---------------------------------------------------------------------------
  309-  323 (19.53/19.92)	PhgIRGKILLDQCLG
  327-  339 (24.90/15.91)	P..IARAVWLAKCVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.31|      10|      18|     857|     871|       9
---------------------------------------------------------------------------
  857-  871 ( 8.59/19.35)	LIDayAGIKrfgMPS
  878-  887 (17.72/ 8.72)	LIE..LGLR...IPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.42|      19|      37|    1389|    1409|      10
---------------------------------------------------------------------------
 1389- 1409 (35.54/22.30)	LFPaaDYFPHPTPTEGFRPCP
 1427- 1445 (33.88/15.86)	IFP..DEVRHQCARFLKEKCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.45|      11|      15|     807|     817|      14
---------------------------------------------------------------------------
  807-  817 (20.29/14.65)	SFGDISMLADV
  823-  833 (20.16/14.49)	SCGDSTVLASV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13198 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQAVVSELPSNENRGDGAAGSKPPSPPPLPAQPWMNNFVAEPEGSGVVKSRESSPVGAVQTTP
2) GQKPADFAPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALY
3) MIPHSSAGGQSWGHPLRTFNGGPGRVDNAQMLGQYDQPDRSASLPQPPIRQPVVVDLTAGGPESQDREPPPKRPRLDVPSASHTSETGAAGGETRSTPGSAISRPAVSW
117
193
1
179
239
109










Molecular Recognition Features






MoRF SequenceStartStop




NANANA