<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13197

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLPDRAIPEQWRTFLHQCLANRIDIDEFTDLSGLMFARSPVKENELLDLLLEARASSSVTWDPLLPLYVDGLCKVGRVKSSSALASLLKHSSIVDASGSGEVEGEGQGSSSKSKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVIEAADIYSATVDWILAVVAWHNHSVDASQQTGGLMGSPDAVSLFESLGILLAALSGTSKGLEVLSSDFNQALKAKLGQALSSYLPLCIDVSLPLRHRLEELQKVFNLYPGQPSKALHGPAIDGVNVNALQFESSVMDGPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYRNESGRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLPGGGPYVKDDLVSQINNNHERTEQLIGEIESMEGNAGAIVGAVVDVMHNLCHQRETVTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCAILDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISNNDSFLLKLLDRGACSQKLSDLSEKQNNDLGAWIGALFIAEGISEETMSSCSPHEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESETDPTIPIKTLHSLVKPSSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNQSRTDIKPILDALEPYISFRRVGSCRRSELDTWTSHSAGGLIASIRTTLQALVLWSANPGISMAPHAYTHRQVLAGIRMLGATRVLGAIIDEVKQQSEAGSGHIALDIATTMVCAPMTESFAVDQNNYHPVDTSKEALPRCAILTLRDALALQHENVPKISESDPLRAEVVVRLARRVNMLMAPPSQVSNIDVSNIIQNMHLGVEGQEDRMDLEPSAADVERNTVNEDDPDNINQMLDKAAADAAAAGMDGGIGVGQDMGLDSGAGMDAIDDVLNAADMAVGNPEFLDLDMEDL
Length1034
PositionTail
OrganismPenicillium solitum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.029
Instability index43.56
Isoelectric point4.78
Molecular weight112675.02
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13197
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.20|      26|      72|      84|     109|       1
---------------------------------------------------------------------------
   84-  109 (43.34/26.63)	LASLLKHSSIVDASGSGEVEGEGQGS
  159-  181 (39.36/23.48)	LAVVAWHNHSVDAS...QQTGGLMGS
  184-  204 (23.49/10.92)	AVSLFESLGILLAALSGTSKG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.23|      92|     620|     250|     345|       2
---------------------------------------------------------------------------
  250-  345 (149.09/117.68)	NLYPGQPSK.ALHGPAIDGV.NVNALQFESSVMDGPVVNTRAGLYVYIN...SMVVGRP....LVDDTILINYLTNRYQGHNDVLieEIITAAFDVLSNGVyrNE
  867-  967 (138.14/96.31)	NYHPVDTSKeALPRCAILTLrDALALQHENVPKISESDPLRAEVVVRLArrvNMLMAPPsqvsNIDVSNIIQNMHLGVEGQEDRM..DLEPSAADVERNTV..NE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.48|      27|      31|     432|     462|       3
---------------------------------------------------------------------------
  432-  460 (43.02/26.39)	EQLLGEnpMQTLPGGGPYVKDDLVSQINN
  466-  492 (43.46/23.03)	EQLIGE..IESMEGNAGAIVGAVVDVMHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.75|      22|      25|     981|    1002|       4
---------------------------------------------------------------------------
  981- 1002 (37.77/24.44)	AADAAAAGMDGGIGVGQDMGLD
 1009- 1030 (36.98/23.77)	AIDDVLNAADMAVGNPEFLDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.09|      31|     620|     123|     153|       5
---------------------------------------------------------------------------
  123-  153 (52.73/39.68)	TDIKVIQDVM.VFIS...TGSIPKTVIEAADIYSA
  744-  778 (47.35/34.80)	TDIKPILDALePYISfrrVGSCRRSELDTWTSHSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      23|     300|     387|     420|       8
---------------------------------------------------------------------------
  359-  381 (40.51/27.00)	NKLPAF...FAAISAASMVPISMEM...C
  392-  420 (31.11/28.89)	NAFPSFsqmFSMQGSSVLSDARQEFlfaC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13197 with Med5 domain of Kingdom Fungi
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