<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13182

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEESRGPNQPQEGPTNGYTILKHLSRLKDLEARLRSLNCLASSPRRLGLWVFSSTPEFESLKPLYLSGEDNNKIVVGTTTLKVGALGSVTALDLVKGLTDNQAQVAQPGQPRPTQGQAPPRRQDGLINSAGIYAAFISAVTGSISLQLIRCHGALPLGSRTLYTAVEKLGYESSHIDNDSIFSNSCLTTLNVQLTLGGTITVSAQTVPQTGIRRLAPRDNVADLLSMQPGIDLWLCPNGTIARLVTANIDAPTASSPGHPTSGDVSAQRLQWKLDVIQWLQNFGLQIGSADEESWVEIEVWEAFYARLAGEAWRQSDDGQSALPLKRMLWPARFCFRRASSSNTTFETQMPLFDDPLDFADRWTSQASSLKLDHSAQNIHFPQERQIKEQEISPSPKADHLESTESLSRIAQYPDLQNTNLVYPTPPDGAAATDMNNPNPSEAFAEDSDFGLPNAPPRDPQRDASGSEPSPGNEIGVGTGRYDASDEEDLFGDMNDRDFGSKGITDADFSFFDDPDFEGMGDEHVEQPQGTIQASQDLSRLEDEPMIDENSSPNLPLEIPNDAETEAYVSPMQKEAPQPNEPISPQGVAHSPTDRTGQTISPPLSPIEIKKILFPEHETNDDRISTDIHGQGHYHPVAFEKKLCDWDQKYGTAGKFWFSGGGPSDIYEQTSAIPTIGLPHRNRTSINTSAAAKERSRAILSLVQTKKGLPSSSVSSSDSDESSDDMAEVMPEHPPTPSVPSLIPSLKRKRAPSDTEPMSVASPEKQLTTTEASPALKVENFTFLGNFLANFSDWTLTGYFSALQSQQTPVLLLREDQLQIAQLLVEQITQSSLKHPLDEQNGPVNLESQSLLQSLDDAEFPGEVSKLDFKRYTSLQDEFTANHPQQQPPQYPMPPKDVLRGFIARLPAPHIRVRRGKEYLEALPFAVNFWETFGLQPAHGPKNISAYCIYPHTASNAADLFLGRLGLLYEEGCSLGTHTRGDDSAGFEKGLKSWQSGSSSYESMMLVLKKMCEELGTELSQSPPTADNCVVYIINPFTHTAALADICSAFWHLFQQLVADSERRQVRPVNELVLQIIPMEFVMSSEALVMPSQEDYLNLALEVYGRCRPKGNDTSPLLCTPPIFLADPLPRAISFRLAPERTSPLQDGRSLHIACSRSLDQRWISVAWSDVAGSIQRTVSYCLKYRQSSGIRPIADVRNEIWATTKHIMEKIQARWKVQLVTTEPMESDEVEAWTSFADQYNKSRPTSLELTILSVNAIPDLILEPPISPISMAVFNPLSTTPVSTPNPNNSIASPEQSGNAATPSSGGPAAYNAPTPTDMSLEPDPDLALTDICDESWLAVLSHRLNSSAHLTDFRPALSSGYLLRRKGPTDSDGVFALTANLIYSARPPPAHDNVLKDTLSMYRDMATLARVKGIRCVQGNTLPWHIATALRAQELLSYTF
Length1468
PositionKinase
OrganismPenicillium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.420
Instability index55.15
Isoelectric point4.92
Molecular weight161401.79
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     672.08|     254|     281|     481|     761|       1
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  481-  650 (196.78/113.98)	................................................................................................................................PPRDPQRDASGSEP....SPGNEIGvGTGRYDASDEED..LFGDM..NdrdFGSKGITDAdFSFFDDPDFEG..MGDEHVEQPQGTIQASQDlSRLEdEPMiDENSSP.NLP....LEIPNDAETEAYVSPMQkeaPQPNEPISPQGVAHSPTDRTGQTispPLSPIEIKKILFPEHETNDDRIS
  654-  939 (383.97/196.00)	HGQGHYHPVAFEKKLcdWDqKYGTAGKFWFSGGGPSDIYEQTSA......IPTIGLPHRNRTSINTsaaakeRSRAILSlVQTKKGLPS..SSVSSSDS.....DESSDDMAEVMPEHPPTpsvpsliPSLKRKRAPSDTEPmsvaSPEKQLT.TTEASPALKVENftFLGNFlaN...FSDWTLTGY.FSALQSQQTPVllLREDQLQIAQLLVEQITQ.SSLK.HPL.DEQNGPvNLEsqslLQSLDDAEFPGEVSKLD...FKRYTSLQDEFTANHPQQQPPQY...PMPPKDVLRGFIARLPAPHIRVR
  940- 1050 (91.33/31.07)	RGKEYLEALPFAVNF..WE.TFGLQPAHGPKNISAYCIYPHTASnaadlfLGRLGLLYEEGCSLGT......HTRGDDS.AGFEKGLKSwqSGSSSYESmmlvlKKMCEELGTELSQSPPT................................................................................................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     369.20|     129|     931|     169|     329|       2
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  157-  304 (178.39/114.02)	IYAAFisavtgsISLQLIRCHGALPLgSRTLYTAveKLGYESSHIDNDSiFSNScLTTLNVQLTLGGTITV.........SAQTV..PQTgiRRLAPRDN.VADLLSMQPGIDLWLCPNGTIARLVTANIdAPTASSPGHP.TSGDVSAQRlqwKLDvIQW
  325-  435 (129.48/80.26)	VWEAFyarlageAWRQSDDGQSALPL.KRMLWPA..RFCFRRASSSNTT.FETQ.MPLFDDPLDFADRWTSqasslkldhSAQNIhfPQE..RQIKEQE......ISPSPKAD.HLESTESLSRI....................................
 1131- 1188 (61.33/19.71)	.............................................................................................RCRPKGNdTSPLLCTPP...IFL..ADPLPRAISFRL.APERTSPLQDgRSLHIACSR...SLD.QRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.41|      23|     884|     439|     474|       3
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  439-  461 (44.06/13.64)	PDLQNTNLVY...PTPPDGAA.....ATDMN
 1321- 1347 (32.86/ 6.84)	PE.QSGNAAT...PSSGGPAAynaptPTDMS
 1383- 1408 (32.49/19.39)	PALSSGYLLRrkgPTDSDGVF.....ALTAN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.12|      10|     286|    1067|    1076|       5
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 1067- 1076 (20.95/15.09)	ALADICSAFW
 1355- 1364 (21.17/15.35)	ALTDICDESW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13182 with Med13 domain of Kingdom Fungi
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