<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13175

Description Uncharacterized protein
SequenceMIPHSSGQPWGPSLRTVNGPGRLDNAMGYGHSDRPMQQPSRPTVVDLTAGGSESQDREPPPKRPRLEVPGGANATDTGAPANTEARSTPGSATSRPTVSWRGRPLWSFQAVVSELPNSENRGDVAGSKPSSPPPLPAQPWKTPAVEPPATNVVKSRESSPVGAVQTTPYRIEIPSAAPIYHNEKPADFTPWTGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPALYAQLKHRTGLQMLSSVFAAALEKRQTHNSVDRESSFKPPPRVTLTDNKREVWLRELANPTVPLRKLSRTIPHGIRGRLLLDHCITKWIPVARAVWLAKCVGANEIRAFKRKGTNGALAVGLEAKWVREWTTNVQQFVEATFSAPKSSDWKAKMTYAVGLTARLFFENLLDHDHFLEWFLTCFETASLGTIPVWLLMLGVYWKSILRYRRRGRRLAELLLEKLRQATEAKLAPLQPLIDRLGHFIQRLIRDHTSSMILPNTWETYKTQVASVLDLENAFEKALFQNLAERNARVQRPNHSKQTDTRSPHQRIIRLLDSIRSAHDISSISSCFDTFEDKAVLVSKLLEWLSTPFRHGLCRIYIGARLLRKWKLAGVDIDSHILAFLSRGQNNQKLNMDQIYHVISELVRSQTFSVGRYLQWLMAKGVTNSPSTKDHNVKNLPIDIGLIAQLPVGRLPEHVANLRNTLLTRTGLSVSEEPAVIDNVKDIISQRLPAIFGGSAHATMELDSLPPNLTWAVKAEIGQWLRRAIAQHSRNATESSTTGVFAAGVLPVVSALTPIEFYTVRDILESFGDISMLADVLNFASSCTDGTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGIKKFGMPSLDLIFSLIELGLRIPSELNTVAILRQDLSRMENKSIMAAYSPVSDHIPDNFGDTDPFLREKLDQILLTGNVMDEPTLDAIFSALTKHLEAEEGHSKLSANDTCRYLAQLRSFHPKHFDVILARWVCGHLRSPDRTTLLRILPPLIGVGCVTIRAFLALAKRLTLSTPTTIPNTAHLPADLVQLLLPSTKESRRFDLVSYRFQLAQQEFLTKNTEEALKIVCDAAASANSGDAPAKYDNLENSMVMLLRDLLVRKPDCVAQKCMQKLAEQYPAALVIVQKALDLLLDVDSYSAGKSVLSEIQKLASMTDDFSLPFCQLKLQVLFHADSGTEDRNSIVDAMFKTAVADCRAHRLHWVDLVALMSPDAVRQIRERAEKEFFSIPLFEDLTSDNSDQPDNLGPLEAAKLHLTIIEELAGSVPESGTSSVGPVLVEKMDALLHKIITMHSTLANTQSTANQTRTKFERGLAFWFSALLRMVVIHRSAFINQPQTLKPNPPHDQLRLLISIFCIALSRLPGNVLRLYPAADYFPHPTSTPEDYRPCPGILLQTHALDVAASLIDIFPDEVRFQCARFLKEKCPSFVPFQNDSRFLYLLGPTPDQTSVNPQQTSVPSPAASTSTPAQTPAPVSAVAVSAAQQSALAASSAYSDDMNCIANRLRLQYRGRVVGPYPVRPWELLEDAAPFRSMNDTSVNLGYFDARRLIPSIRSLLSTQISNGTLGGIALVNGSLGSIARATKTVAYLPLDCAVRAASLIETAAAATTAPLPPVLLLSSAVTVVVTSRVWVSVVVTVETSVMT
Length1654
PositionKinase
OrganismPenicillium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.144
Instability index42.71
Isoelectric point8.66
Molecular weight182663.12
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13175
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     291.72|      94|     195|    1223|    1324|       1
---------------------------------------------------------------------------
 1223- 1324 (139.39/111.83)	PDAVRQIRERAEKEffSIPLFEDLTSDnSDQPDNLGPLEaaklHLTIIEELAGSVPESGTSSV......GPVLVEKMDALLHKIITMHSTLANTQS.TANQTRTKFeRG
 1421- 1521 (152.33/97.48)	PDEVRFQCARFLKE..KCPSFVPFQND.SRFLYLLGPTP....DQTSVNPQQTSVPSPAASTStpaqtpAPVSAVAVSAAQQSALAASSAYSDDMNcIANRLRLQY.RG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.95|      17|      37|      85|     101|       2
---------------------------------------------------------------------------
   65-   81 (22.98/ 8.69)	RLEVPGGANATDTGAPA
   85-  101 (29.50/13.35)	ARSTPGSATSRPTVSWR
  125-  141 (27.47/11.90)	AGSKPSSPPPLPAQPWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.25|      21|      37|     345|     365|       3
---------------------------------------------------------------------------
  345-  365 (38.39/25.04)	AVGLEAKWVREWTTNVQQFVE
  383-  403 (36.86/23.74)	AVGLTARLFFENLLDHDHFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     156.31|      49|     195|     668|     721|       4
---------------------------------------------------------------------------
  652-  689 (36.14/29.29)	.......VTNSPS...TKDhNVKN...L........piDIGlIAQLPVGRLPEHVANLR
  693-  721 (32.18/14.86)	LTRTGLSVSEEPA...VID.NVKD...IISQRLPAI.......................
  891-  925 (22.21/ 7.34)	MENKSIMAAYSPVsdhIPD.NFGDtdpFLREKLDQI.......................
  926-  970 (65.77/37.75)	.LLTG.NVMDEP....TLD.AIFS...ALTKHLEA...EEG.HSKLSANDTCRYLAQLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.79|      16|      37|    1134|    1149|       6
---------------------------------------------------------------------------
 1134- 1149 (24.68/14.94)	LVIVQKALDLLLDVDS
 1172- 1187 (29.11/18.97)	LPFCQLKLQVLFHADS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13175 with Med12 domain of Kingdom Fungi
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