<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13173

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNVNIDGSVRRPGLNEASNGGSNSLRNVDKSAQMSSSMNGSAHVNGTSGAVDASNQTSLAGKAGGNVPTTPFELTHITQGFFPFGTLVNRSVQQCWNELSELITELAAVQVPHQAASGATNGKAPGNQSSENIHKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTALLVLSKGQVTSLPDLGYSPLKPLTARATLKKLLKLNRIISVRLALHDSVPHALRHYRVHDGRVTFTVPGEFELDLSVAEVSTISQFFFVDIRFLFSPSSPIPEGRILNELDAKINEILRNDGLMGCFNFLHGLVLTNKINILFRQATDLARGLWADALHIELLHRTLVVQYWSQRTGPKSWLEIGINSGHRSSNSSNSMPGTSHLGFRWMRDGQLAISDAIQFDTDDLSMERILRSVVALHSSHVLSAAFTTLKKHLLFSKHTLSLQAQLSSTEPGECYLDVQLTASRSVRVSIEPMSGSIILCVTPNVPERLDNDRIVHKSSFEEILTRVSRLRCTTAVEEIESGTKALGLETLSQRVLGLDPRKLFPPGVMRSAFFSHPLWNRQWVAAATSSMDGDRWWLVQLRPTGTARAIPPYSGGETGISLPRAHVISESLVSAQGRLDYTTCAELVHALTGILAIFANACYLSELPALRFLPPLKELQMQSDLIIPDLIFSYNPATLPPALRIALPSGVNRESQLKEIVRLAFQGVDSKSRSIIMVAHGTLKNRIKSLVPLISKTDSSLITEDKGAGFALRLLVPAGHSIIVGLFERLQRFECVLSILQSLIQNGMEPRSLSLSQIAFAYGKETKSSASFDIGVSGPTLSDYVDMAAISKSQPLFHLQLGIKFESSSPHRRIQEALAVALNHRFTDTGVKSILRLMSFTLPLLRSFDQITNISNQTDSSIVYITVRGPTEYQIHYPRVNARFRLNRIVHQDEQVWMLRDANTDNQFGRDQIAIAIREKLYHSKGDGWNGLGDGAVGMPDKVGNLLAELHLCLSSPHLELDKEAKGKAAVPEPLQTKGQVSVLPNKTASNQASGLGNTDVITID
Length1085
PositionTail
OrganismPenicillium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.097
Instability index44.52
Isoelectric point9.06
Molecular weight119207.05
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13173
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.73|      25|      92|     834|     860|       1
---------------------------------------------------------------------------
  834-  860 (34.69/35.20)	SLSQIAfAYGKETKSSASFdIGVSGPT
  927-  951 (45.05/32.66)	SFDQIT.NISNQTDSSIVY.ITVRGPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     659.46|     189|     190|     391|     580|       2
---------------------------------------------------------------------------
  249-  389 (135.41/99.37)	...........................................................LKLNRIISVRLALHDS..........VPHAL..R.....HYRV.HDGRVTFTVPGEfeldlsvaevstisqfFFVDIRFLFSP......SSPI...P.EGRILNELDA.KINEILRND..GLMGCFNF..LHGLVLTNKINILfRQATDLARGlwADALHI...ELL.HRTLVVQywS
  391-  580 (308.92/245.78)	RTGPKSWLEIGINSgHRSSNSSNSMPGTSHL.GFRW....MR.DGQLAISDAIQFDTDDLSMERILRSVVALHSSHVLSAAFTTLKKHLLFSK.....HTLS.LQAQLSSTEPGE................CYLDVQLTASR......SVRVSIEPMSGSIILCVTP.NVPERLDND..RIVHKSSF..EEILTRVSRLRCT.TAVEEIESG..TKALGL...ETLSQRVLGLD..P
  582-  772 (215.12/164.34)	KLFPPGVMRSAFFS.HPLWNRQWVAAATSSMdGDRWwlvqLRpTGTARAIPPYSGGETGISLPR..........AHVISESLVSAQGRLDYTTcaelvHALTgILAIFANA....................CYLS.ELPALRflpplkELQMQSDLIIPDLIFSYNPaTLPP.....alRIALPSGVnrESQLKEIVRL.....AFQGVDSK..SRSIIMvahGTLKNRIKSLV..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.95|      15|      20|      35|      51|       5
---------------------------------------------------------------------------
   35-   51 (22.48/19.29)	DKSAQmsSSMNGSAHVN
   58-   72 (26.47/15.29)	DASNQ..TSLAGKAGGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13173 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NIDGSVRRPGLNEASNGGSNSLRNVDKSAQMSSSMNGSAHVNGTSGAVDASNQTSLAGKAGGNVPT
10
75










Molecular Recognition Features






MoRF SequenceStartStop




NANANA