<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13166

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGITNNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLNPLYVRGSDAESNRIVVGTTILKVSALGSVSSLDLVKGLSSDNQSQHGTQPAGQPRPHQGQPSPRRQDGYSSSAAIYASFISAVTGSIGLQLIRRHAALPLGSRTLFTAVEKSGYESPHINNDNILSTSCLTTLNIQLTMSGTITVSAQTISQAGITRLCSPHADISERIDVQPGIDLWLCPNGTIAKLVTANIDSSTVPSLGYPAPGNLSVKTLQWKMDVVQWLRNFGLHVGSIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQTALPLKRMLWPARFCFRRASSSNFSSGAQTSLLDEPLDFAERWSTMASSLNLDHISHTAQNTPITQDPQPKDQEMLSPLKPEPLESIESLSRIAQYPDLQSTNLVYPTPPDGTAAVGLNNPNPSEAFADDSDFGLPRTAQRSSRRNAPGSDISPVQNSGVGVGTGRYDASDEEDLFGELNERDFGSKGITDADFSFFDDPDFDGMEGNSLVEDAAEVLEVSHPPSEPEAEAMVDAEPSPNQPQAIPTHVETHEAHASPIYDEAPRLSEEPMATEEPAHSPMDWAGQTISPPLSPVEVKKILFPGPEADDHQQSTDNRGQGHYHPVEFEKKLGDWDQKYGAAGKFWFSSGGTLDTLDQTSSIPTIGMPHRGRSSANAPGSSKERNKPSLSLTQSENGLRSASVSSDSSDDSIEIMSEHVPTPAALPSIPSLKRKRAPSESDIISIASQEKSLPVTEASPTYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLFRREGQLEIAQLLVDQITQSSLKHPLDGQIGLFDLESESLSLQALDDTTLLGETSKMDFKRYTSLQDEFVANQLQQQPPQHPPPPKETPKSFISKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPQSASKAADVFMTRFGLLYQSCSLGTHTRGDDSVAFEDGLRPWKSETASYESMMQVLKRTCEQLGSELSQSPATADNNVVYIINPFTHAAALADICSAFWHLFQQLVAGSERRQTRISNELVLQIIPLEFVMSSETMVIPPETDYLNLALEVYSRCRPDDADMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDLSGSIQRTMSYCLRYRQSSGARPVSEVRNEIWATTKHIMDKFQARWKVQLVTTEPIETDEVEAWASLADQHNKLRPGSLELTILAVNTVPELILEPPVPPISMAMLNILSSSTPVSTPNPSVSVASPEQSGNAATPTSAGPTAYNAPTPTEMSLETDSEAVLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFAISVNLIYSPRPPPSHDNVLKDTLNRKSSECKKEEEDDDDNRDGDVSLHHVGWRRSADRGREVNDLV
Length1481
PositionKinase
OrganismPenicillium polonicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.427
Instability index61.30
Isoelectric point4.93
Molecular weight162239.07
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13166
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     923.42|     311|     350|     143|     488|       1
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   77-  386 (368.60/276.19)	........................................FSP...TPE.FESLNPL..YVRGSDAESNRIVVGTTILKVSALGsvssldlvkgLSSDNQSQ.......HGTQPagqprPHQGQP....SPRRQDGYSSSAAIYASfiSAVTGSIGlQLIRRhaalPLGSRTLfTAVEKSGYESPHIN..NDNILSTSCLTTLNIQLTMS...GTITVSAQ...TISQAGITRLCSPHADISERIDVQPgiDLWLCPNGTiAKLVTANID..SSTV.PSLgypAPgnLSVKTLQWKM....DVVQWL..............RNFGL.HVG...SIDEEPWVEVEV....WEPFFArLAGEAWRQSD......DSQTALPLKRMlwPARfcfRRASSSNFSSGAQTsllDE
  387-  736 (471.36/290.28)	PLDFAERWSTMASSLNLDHISHTAQntpITQDPQPKDQEMLSPL..KPEPLESIESLSRIAQYPDLQSTNLVYPTPPDGTAAVG..........LNNPNPSEafaddsdFGLPRtaqrsSRRNAPgsdiSPVQNSGVGVGTGRYDA..SDEEDLFG.ELNER....DFGSKGI.TDADFSFFDDPDFDgmEGNSLVEDAAEVLEVSHPPSepeAEAMVDAEpspNQPQAIPTHVETHEAHASPIYDEAP..RLSEEPMAT.EEPAHSPMDwaGQTIsPPL...SP..VEVKKILFPGpeadDHQQST..............DNRGQgHY........HP.VEFEKklgdWDQKYG.AAGKFWFSSGgtldtlDQTSSIPTIGM..PHR...GRSSANAPGSSKER...NK
 1113- 1203 (83.46/38.61)	PLEFVMSSETMVIPPETDYLNLALE...VYSRCRPDDADM.SPLlcAP.PMLLADALPRA.......................................................................................................................................................................................................................................................isfrlaperssplqDGRSL.HIAyskSLDQR.WISV.A....W............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.84|      46|     277|     745|     795|       2
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  750-  795 (78.16/44.16)	SASVSSDSSDDS.IEIMSEHVPTPAAL....PSIPS...LKRKRAPSESDIISI
 1363- 1416 (63.68/26.76)	SEAVLTDICDDSwLAILSHRLNSSPHLtefrPALSSgylLRRKGATDGDGVFAI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13166 with Med13 domain of Kingdom Fungi
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