<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13161

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSSHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQQQTQQPTQHRPTDHDRQTLQTESTKDFATGQGQHSTDPDAMDVDTEPTRRADTLGLDLDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGSIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEIGAPGSLRHMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLHSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKAAPASTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMFGIGAR
Length458
PositionHead
OrganismPenicillium polonicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.966
Instability index54.52
Isoelectric point6.63
Molecular weight49422.74
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	PIRNR:PIRNR023869
	 href='https://www.uniprot.org/unirule/RU364151' style='color:#FF0000;'>RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP13161
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.41|      26|      27|      14|      39|       1
---------------------------------------------------------------------------
   14-   37 (39.68/18.87)	.......P..........PS.PSSPA.GSLKE.NHRLPISSEHI
   38-   63 (32.06/13.70)	P.Q.................tPTSPPlMSVNEqSHAANFTSSHT
   65-   88 (27.75/10.77)	PnQatvqP..........PN.ISSPP.SS.......APMSTQ.V
   89-  119 (29.92/12.25)	S.Q.....qptmsttnsfPT.PAS....SVS..SHPANATSEDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.29|      21|      21|     155|     175|       2
---------------------------------------------------------------------------
  133-  152 (32.26/18.67)	SAENSG...AAPAQQQTQ.QPTQH
  155-  169 (18.95/ 7.83)	.........TDHDRQTLQTESTKD
  170-  193 (31.08/17.71)	FATGQGqhsTDPDAMDVDTEPTRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.28|      20|      21|     263|     282|       3
---------------------------------------------------------------------------
  263-  282 (34.29/21.40)	GKLKGLGLAGRNKPHKQEI.G
  285-  305 (34.00/21.17)	GSLRHMTLWPEEEWQNQKVhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.03|      20|      21|     207|     226|       4
---------------------------------------------------------------------------
  207-  226 (36.60/21.94)	ELTSAFHLCKSSPIVTGPDP
  229-  248 (34.43/20.24)	DLVSLYGLGSIAHSVARMDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.62|      21|      23|     352|     374|       5
---------------------------------------------------------------------------
  352-  374 (31.37/24.09)	APGETGKKAAPASTAGRPsmQSY
  376-  396 (37.24/21.80)	ASPRSQEAERPRPSRGRK..RNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      14|     397|     407|       6
---------------------------------------------------------------------------
  397-  407 (22.39/12.16)	DDNSFAGYGEG
  413-  423 (23.44/13.04)	DDPGFYSNGEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13161 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKGLGLAGRNKPHKQEIGAPGSLRHMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLHSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETGKKAAPASTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMF
2) MSDRTHPTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSSHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQQQTQQPTQHRPTDHDRQTLQTESTKDFATGQGQHSTDPDAMDVDTEPTRRADTLGLDLD
265
1
453
202










Molecular Recognition Features






MoRF SequenceStartStop




1) DWWEDILGHE
2) KKKRKKDHVAKVST
336
426
345
439