Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSNLTQEQIKVLEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSDQLSDQRDLLSNLVAYPGPEYPGRTQANTLEQLLRTKLDPRVEDWVARGRTAGTEPAAGQSNFSDPDAAHKPLSEAQLAELWEWAPLEANQEARRRNWGGNFTLEEREAGIENVVTGLRRQLEDDDGSEEESDAEEGDGEEMDVVGVHRKPGAAELEYNIAPHHPHPVQPFVPLDLILRHMTTGRMP |
Length | 247 |
Position | Head |
Organism | Penicillium polonicum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.695 |
Instability index | 56.61 |
Isoelectric point | 4.67 |
Molecular weight | 27479.05 |
Publications | PubMed=28368369 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13160 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 34.63| 12| 15| 45| 57| 1 --------------------------------------------------------------------------- 45- 57 (14.95/12.34) LQSQASIISnNLI 63- 74 (19.68/10.98) LSDQRDLLS.NLV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.02| 11| 14| 201| 211| 2 --------------------------------------------------------------------------- 201- 211 (19.90/13.08) EMDVVGVHRKP 217- 227 (23.12/16.20) EYNIAPHHPHP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) NLVAY 2) VPLDLILRHMTTGRM | 72 232 | 76 246 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab