<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13151

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQGCGSPSGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSAQTGNPLPSTPAPQPAAGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGSSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEETGLSEPMDIDHNSSMIFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKPLLKDKSVEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTANNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEAEKKAAEPAKADKTSSNPATTTEERKKKQSKTKKRNQSSNKTEDFVLGPSRGVSYGVGMPTDLLHHQPGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPPGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQPVRQMAPTPSYGTLQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQRFPHQSIQQAPMMGGMNHLGPQGVPSGIRPSQILPDQQQQQYLRQQQQQQQQMLRFQRQGLQQTQQQQQTAALVRQLQQQLSNTQTQQNNNPFGRY
Length2103
PositionKinase
OrganismPatagioenas fasciata monilis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Patagioenas.
Aromaticity0.07
Grand average of hydropathy-0.447
Instability index52.57
Isoelectric point6.77
Molecular weight234717.38
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13151
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.12|      14|      15|    2046|    2059|       1
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 2046- 2059 (28.23/15.29)	QQQYLRQQQQQQQQ
 2064- 2076 (24.89/12.58)	QRQGL.QQTQQQQQ
 2086- 2098 (17.00/ 6.16)	QQLSNTQTQQNNN.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.78|      18|      18|    1933|    1950|       2
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 1881- 1893 (27.12/11.72)	PS..YKPA...........VYR....QQPP
 1933- 1950 (37.37/19.09)	PSQGYTPY...........VSHI.GLQQHP
 1959- 1988 (21.28/ 7.52)	PTYSGQPYqnshpssnpalVDPVrQMQQRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.94|      14|      18|    1648|    1665|       3
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 1648- 1665 (13.23/24.88)	TKgNKIAGFDsIFkkEGL
 1669- 1682 (28.71/19.78)	TK.QKISPWD.LF..EGL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.25|      72|     108|     922|     995|       4
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  922-  995 (119.19/78.73)	LNQDQmAQVFEGLCGVVKH.GMNRSDGSSAERcILAYLYDLYTSCSHLKSK.FGELFSDFCSKVK.....NTIYCNVEPSD
 1026- 1104 (115.06/66.89)	LNENP.ANRYSFVCNALMHvCVGHHDPDRVND.IAILCAELTGYCKSLSAEwLGVLKALCCSSNNgtcgfNDLLCNVDVSD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.67|      13|      18|     842|     858|       5
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  846-  858 (24.83/20.05)	MSYHLPLVQHVQF
  863-  875 (22.85/ 7.03)	MEYSLNISGLIDF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.30|      18|      18|    1201|    1218|       6
---------------------------------------------------------------------------
 1201- 1218 (29.25/15.14)	GAVFAVLKAVFVLGDAEL
 1220- 1237 (34.05/18.72)	GSGFSHPGGVDDLMDDEL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.44|      32|     110|     192|     223|       7
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  192-  223 (61.30/32.48)	TKYLSEQLQKIAEFYRQ.LPGQ.GCGSPSGPMPQ
  301-  334 (52.14/26.39)	TRRLAMQLDGAGGHPPHiLSAQtGNPLPSTPAPQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.49|      15|      18|    1377|    1391|       8
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 1377- 1391 (25.52/15.61)	SASSAGNGVNNISSS
 1393- 1407 (25.96/16.01)	SATPASNKSKPILSS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.68|      15|      22|    1994|    2010|       9
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 1994- 2010 (23.97/22.80)	QQAP...GYGHtLGnTQRFP
 2015- 2032 (27.70/15.34)	QQAPmmgGMNH.LG.PQGVP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.62|      18|      22|    1749|    1770|      10
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 1749- 1770 (20.11/23.95)	KKAAEPAKADKtSSNpatTTEE
 1773- 1790 (30.51/18.21)	KKQSKTKKRNQ.SSN...KTED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.32|      15|      18|     346|     362|      11
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  346-  362 (23.49/18.86)	SDLLLCPQhrPVVYGLS
  367-  381 (30.83/17.37)	SIILCCPS..ALVWHYS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.61|      21|      23|    1540|    1562|      12
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 1540- 1562 (29.70/26.40)	QQTTewAVL.LLDIISSGTV..DMQS
 1565- 1588 (24.91/13.55)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.81|      19|     106|    1722|    1743|      13
---------------------------------------------------------------------------
    8-   29 (34.46/12.26)	SYEHRPLKRPrlgPPDVYPQDP
 1724- 1742 (38.36/16.19)	SYYLEPLPLP...PEEEEPPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.76|      41|     211|    1261|    1301|      14
---------------------------------------------------------------------------
 1261- 1301 (71.22/41.32)	VLRSICQQEWVGERCLKSLCED.....SNDLQDPVLSSTQAQRLMQ
 1473- 1518 (66.54/38.10)	VLTCLKGQDEQREGLLTSLYSQvqqivTNWREDQYQDDCKAKQLMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.51|      59|     110|     529|     591|      15
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  529-  591 (91.96/67.61)	EKRQAEIEaercGDSEV.VDEKGSISSGSLSAASAPVFQDV.LMQFLDTQAPMLTD....PGKENEKVE
  642-  706 (94.55/59.56)	EHDRKETE....GNSGIkLEETGLSEPMDIDHNSSMIFDDMeKTDFSMFSPPMHCEskasPSPEKPDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.68|      15|      18|     492|     506|      21
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  492-  506 (25.94/15.41)	SHEISPDDDA.VVALL
  512-  527 (21.74/11.74)	SYKRSGRHRAmVVAKL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.13|       9|      24|    1813|    1836|      23
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 1796- 1805 (13.97/ 6.19)	SRgVSYG...VGM
 1819- 1830 (12.16/12.99)	SR.LAYGqspVGL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.02|      11|      15|    1848|    1858|      24
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 1848- 1858 (21.35/13.40)	YRPVRMP.LGKL
 1865- 1876 (17.67/ 9.43)	YSGVLPPgMGSM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13151 with Med12 domain of Kingdom Metazoa
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