<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13128

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVTGPETDWRSTNFRQKLVSQIDEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGAPMSGMSGLGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQAQQSAMQQQFQVRAQLVQQQQAAAAVQAAQAQAAQMGASGQMITAPMARGGMQIRPRFPPTTAVSATPPSSIPLGGQQMPQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPIASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length629
PositionTail
OrganismPatagioenas fasciata monilis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Patagioenas.
Aromaticity0.04
Grand average of hydropathy-0.625
Instability index77.28
Isoelectric point9.71
Molecular weight68569.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13128
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.71|      26|      27|     150|     176|       1
---------------------------------------------------------------------------
  150-  175 (46.04/13.71)	QQTQLQLQQIAQQQQQQQQQFQQQQV
  278-  303 (46.68/11.62)	PVQQAQTPQSMPPPPQPQPSPQPGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.85|      19|      35|      81|      99|       3
---------------------------------------------------------------------------
   81-   99 (37.23/13.62)	PMNALQNLTG.GPPAGAPGM
  118-  137 (33.62/11.64)	PMGQQMSLPGqQQPPGTSGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.59|      20|      22|     178|     197|       4
---------------------------------------------------------------------------
  178-  197 (36.57/18.24)	QQQQFQAQ.QSAMQQQFQVRA
  201-  221 (28.02/12.10)	QQQQAAAAvQAAQAQAAQMGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.55|      16|     203|     246|     261|       5
---------------------------------------------------------------------------
  246-  261 (30.40/11.74)	AVSATPPSSIPLGGQQ
  442-  457 (31.15/12.21)	AVPTPPPPPVPPTKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.77|      12|      34|     304|     315|       6
---------------------------------------------------------------------------
  304-  315 (23.58/10.12)	TSQPNSNVSSGP
  339-  350 (23.93/10.39)	TPQNFSVPSPGP
  354-  363 (20.26/ 7.59)	PGNPNSVMS..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      14|      23|     524|     537|       7
---------------------------------------------------------------------------
  524-  537 (24.62/15.19)	VARLNPKFLVNLDP
  549-  562 (26.92/17.33)	ICKLDDKNLPNVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.99|      19|      34|     387|     405|       9
---------------------------------------------------------------------------
  387-  405 (32.53/25.12)	PLRRM.INKIDKNE...DR.KKDL
  418-  441 (20.45/13.07)	PSKRCpLKTLQKCEialEKlKNDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.73|      14|      22|     462|     475|      10
---------------------------------------------------------------------------
  462-  475 (23.18/12.94)	PLLDAVLA.NIRSPV
  486-  500 (21.55/11.54)	PAMTAIHGpPITAPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13128 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQNLTGGPPAGAPGMGMASRAQGAPMSGMSGLGPMGQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQQFQQQQVALQQQQFQ
2) QAAAAVQAAQAQAAQMGASGQMITAPMARGGMQIRPRFPPTTAVSATPPSSIPLGGQQMPQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQ
70
204
183
380










Molecular Recognition Features






MoRF SequenceStartStop




NANANA