<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13126

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVDVIHRELHMVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLITEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQNAANTGGHINVGQQGLGSMKDPASTCGMPLTPPTSPEQTVLGESGCSQSSISHSALQEGTVSVHSPKKSRKITPKIHNRMVHRVWKECILNRSQSKRNQMTTANLEEEVPNNTVSWDFVDPVQRVSCSCSRHKVFKQRCAAGSSRPPTINQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPLMPFHHRPSVTEELCMEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQMNMNPMDSPRSPTSPLPPTLSPQPRGQEGENLDPPSVAVTPALYGSGLELQPLPSLDERTVLVGQRLPLMAEVSETALYCGITHNSESRDIWRAYSVPLSDDLEFRPPALPCERYDAKMEITSDSSALKRLLAQPNKRFKILREQKPVQTLNYLDSLPLIQAPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLGAEKDPLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTALGMMESPMVNMVPTQLAEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSVFAPLKILPSQCLLPLKVPDACIFRPSWAVPPKIEQLPLPPTATFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCMNWSYDRLQADSNDSWVECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPASQTQPVPGNAGPVPPNSACLSAAGAAPTGSSFGSAPGGGTTGLPTGSSSASGSSVPQLAASSATPGVNQMNATTAPGFSGNIGSGQNTSTGGNTAERAQGSTGPGGEMESGQNLPQQQEGQEGVTERERIGIPTEAESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKVSARKIGLQKLWEWCVGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGPHFQPSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPKWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2214
PositionMiddle
OrganismPatagioenas fasciata monilis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Patagioenas.
Aromaticity0.07
Grand average of hydropathy-0.373
Instability index58.67
Isoelectric point5.69
Molecular weight243150.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13126
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.63|      25|      27|    1595|    1621|       1
---------------------------------------------------------------------------
 1595- 1611 (20.42/ 7.45)	............SSATPGVNQMNATTAPG
 1614- 1639 (38.76/26.68)	GNIGSGQN...tSTGGNTAERAQGSTGPG
 1640- 1667 (30.45/12.47)	GEMESGQNlpqqQEGQEGVTERERIGIP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.28|      22|      27|    1015|    1036|       2
---------------------------------------------------------------------------
 1015- 1036 (39.35/19.66)	TPQMNTPVTLN....SAAPASNSGAG
 1043- 1064 (40.98/20.84)	TPRFSVPTPRT....PRTPRTPRGGG
 1541- 1563 (20.94/ 6.43)	.PGNAGPVPPNsaclSAAGAAPTG..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      20|      28|    1132|    1158|       3
---------------------------------------------------------------------------
 1132- 1151 (40.85/41.47)	CICACNMNIK.GADVGLYIPD
 1162- 1182 (34.53/16.93)	CGFSAIMNRKlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.28|      23|      27|     542|     568|       4
---------------------------------------------------------------------------
  544-  566 (44.27/18.13)	NPMDSPRSPTSPL....PPTLSPQPRG
  570-  596 (31.00/10.05)	ENLDPPSVAVTPAlygsGLELQPLPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.61|      25|      27|      60|      84|       5
---------------------------------------------------------------------------
   60-   84 (48.54/28.39)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (49.06/28.77)	FWWGDEPNLVDVIHRELHMVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.71|      24|      27|    1976|    1999|       6
---------------------------------------------------------------------------
 1976- 1999 (41.28/27.63)	VFGRSTALNLQSSQLNTP.QDA.SCT
 2001- 2026 (33.43/20.63)	ILVFPTSATIQVAPANYPnEDGfSPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.40|      25|      27|    1863|    1889|       8
---------------------------------------------------------------------------
 1863- 1889 (40.34/27.85)	ID...LPNRSRRSKVSarKIGLQKLWEWCV
 1892- 1919 (40.06/21.76)	VQmtsLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.55|      18|      20|     960|     978|       9
---------------------------------------------------------------------------
  960-  978 (32.54/19.56)	LPLkVPDACIFRPSWAVPP
  983- 1000 (35.01/17.08)	LPL.PPTATFIRDGYNNVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      14|      20|    1377|    1390|      11
---------------------------------------------------------------------------
 1377- 1390 (27.59/14.45)	SPEPLPI..PTLLVGY
 1398- 1413 (22.92/10.60)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.94|      20|      21|    1695|    1715|      12
---------------------------------------------------------------------------
 1690- 1711 (24.88/20.96)	FTYTaDE..ESASTNFwLLSLMRC
 1712- 1734 (26.06/15.02)	YTEMlDNlpENMRNSF.ILQIVPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.91|      28|     392|     436|     463|      14
---------------------------------------------------------------------------
  300-  334 (34.55/16.78)	NTGGhINVGQQGLGSMKDPAStcgmplTPPTSPEQ
  338-  362 (32.84/15.49)	GESG.CSQSSISHSALQEGTV......SVHSP...
  446-  473 (46.53/25.84)	NQPG.FSVGTSSSSSLPPPAS......SKHKTTER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.43|      18|      21|     727|     744|      17
---------------------------------------------------------------------------
  727-  744 (29.97/14.96)	GNKKCKLGAEKDPLKKNK
  750-  767 (30.46/15.34)	GTKEIPTTGHSTPVPDGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.88|      58|    1267|     156|     215|      19
---------------------------------------------------------------------------
  156-  215 (98.67/71.34)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLITEEHI.HMAQSSPSPF.QVLVS.....PYG
 1426- 1490 (89.21/55.99)	PENEA.LLDGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGImRVGKTVAQKLtDELVSewfnqPWG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13126 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAEKDPLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPV
2) GSLADQDYLQMNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATV
3) NAANTGGHINVGQQGLGSMKDPASTCGMPLTPPTSPEQTVLGESGCSQ
4) NLHSSPNSSPVPSPGSPSGIGVGPHFQPSRSQGERLLSREAPE
5) PPKYQTPASQTQPVPGNAGPVPPNSACLSAAGAAPTGSSFGSAPGGGTTGLPTGSSSASGSSVPQLAASSATPGVNQMNATTAPGFSGNIGSGQNTSTGGNTAERAQGSTGPGGEMESGQNLPQQQEGQEGVTERERIGIPTEAES
6) RCAAGSSRPPTINQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPLMPFHHRPSVTEELCMEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQMNMNPMDSPRSPTSPLPPTLSPQPRGQEGENLDPPSVAVTP
734
1003
297
2050
1527
434
878
1100
344
2092
1672
581










Molecular Recognition Features






MoRF SequenceStartStop




NANANA