<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13121

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSIPMVPMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDERTKLISCLGAFRQFWSSLSQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVVAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAMCNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAHSDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNMGISLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSNLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQVFFKQNNVPQESRFNLKKNVEEEYRKWKSMNTENEIISHFSAQGSSPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVNPPVQIQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYELHLRERPNLKRKLVHAIIGSLKDNRPLGWCLSDTYLKCAMNAREENPWIPDDIYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVINSPSLTSETEWVGYPFQLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTELLIPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYEMLLNADRYSSHLNYIDPICDFLYHMKYMFTGDSVKDQVEKIICNLRPALKLRLRFITHISKMEQAAVQQQPVNNGSPAQQPSQVPVNVALPVRKTEFVSAVAGNSGVQKHLPHSALCLYRTCTYGS
Length1409
PositionTail
OrganismPatagioenas fasciata monilis
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Columbiformes> Columbidae> Patagioenas.
Aromaticity0.10
Grand average of hydropathy-0.012
Instability index45.16
Isoelectric point7.43
Molecular weight161025.36
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13121
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.12|      20|     127|     591|     611|       1
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  591-  611 (33.53/23.83)	FISQLLPTV..FKSHAWGIlHTL
  718-  739 (36.59/21.57)	WCKDILQTImsFTPHNWAS.HTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.01|      40|     785|     181|     221|       3
---------------------------------------------------------------------------
  181-  221 (70.12/51.79)	NACL..LPAY.FAVTEIRKLYPEGKLPHWLLGNL..VSDFVDtFRP
  932-  956 (33.72/18.22)	.................HKKYPE.KLYFEGLAEQ..VNPPVQ.IQP
  965- 1008 (52.17/32.80)	NVCLrfLPVFdIVIHRFLELLPVSKSLETLLDHLggLYKFHD..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.21|      51|     741|       6|      63|       4
---------------------------------------------------------------------------
    6-   63 (81.24/59.72)	VPMETQLQsifeevVKTEVIEEAFPGMFMDTpEDERTKLISCLGAFRQF....WSSLSQESH
  755-  809 (84.97/47.04)	VPQESRFN......LKKNVEEEYRKWKSMNT.ENEIISHFSAQGSSPLFlcllWKMLLETDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.67|      31|     674|     404|     435|       7
---------------------------------------------------------------------------
  404-  435 (54.27/37.80)	KLFDLLyPEKECIPVPD....INK.PQ.STHAFAMTCI
 1081- 1117 (44.40/25.32)	RLVDTM.AGKSPGPFPNcdwrFNEfPNpAAHALHVTCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.09|      39|     301|     854|     896|      10
---------------------------------------------------------------------------
  854-  896 (58.91/60.87)	IEILNDMVWkynIVTLDRLILCLAMRSHEGNEAQVCYfIIQLL
 1160- 1198 (71.18/55.59)	ITALPEPYW...IVLHDRIVSVINSPSLTSETEWVGY.PFQLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.34|      41|     372|     647|     688|      11
---------------------------------------------------------------------------
  647-  688 (63.67/51.43)	QLHLcVESTAL..RLITA.LGSSEVQPQFTRFLSDP..KTVLSAESE
 1020- 1065 (60.67/42.54)	ELHL.RERPNLkrKLVHAiIGSLKDNRPLGWCLSDTylKCAMNAREE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.11|      72|     872|     332|     403|      14
---------------------------------------------------------------------------
  332-  403 (126.68/86.37)	GTSQLLWQHLSSQLIFFV..LFQFASFPHMV...LSLHQKLAGRGLIKGRDHLMWVLL...QFISGSIQKNALADFLPVM
 1229- 1308 (113.44/76.46)	GQLSLIPKFLTELLIPIVktEFQLLYVYHLVgpfLQRFQQERTRCMIEIGVAFYEMLLnadRYSSHLNYIDPICDFLYHM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13121 with Med23 domain of Kingdom Metazoa
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