<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13112

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDWHSSFPATERMKFIGIIMSTLKEMAAAANPGNVDIQKLKNSAEEIERQCFESSPARDNYLGQLKQKIVAMKAQTQQFRTIQSQRAAGQPQQQQQQQQQQQQQQQQQGMLNMSGMSQGSNMPQQTQPSQQPMGQRSVNQSQAFLAQQAQARHQAAQQLRSSQQSQVPNNSSAANFNQMNRGQPQNPNIQLSNANAGNKTNASSQGANMGGQAQPMPTSQSELNNLMRTVRIPPAILNKIPGLPPNTNTWQQVFELATQLAQSQQSPMSSNLTQDDISRLTKNALQLLNVTNQLSESQKAIVREKANELLNPLFSMIDHLVPTFYTLSKSVEGTKKLLHMRFMIKEVIDGLKKNEYFAGPDMLEKLKIQSQRYVEYLNNVTRFNSSPAMGNASFVPNNFNNSPQMGNLNIYPQGQGVNAVPSSQQNTGRPYNNAMPQTHNIPHAIAPQQKVQPAPTPSSIASAPTPGSAAATANQKKPPAKRKSKAAAAAAPKKTSAASTPAIPSKSIATPDVSGSDSNSNASQSHLVKREQDIVNKEALSAKHFEEARNKRLELFFVNPVDLFAASLANLLELNDEEAKIINSKPKFTVDSKNSPFPKTMLTPSAILQTPLTFSNAKTPGSTSKAANGTMPASAMHLSSPKLSPNLKIETMKWAPKVTREAIVATFKSVSEIQKVTLDSGSDADALIPTPPPDDAAVKKRGSEGDLSKDVATFKSIKLSDDNKFFNERDEELPTDSMWDYDFVSTHLTFDDQEVGF
Length757
PositionTail
OrganismCyberlindnera fabianii (Yeast) (Hansenula fabianii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Cyberlindnera.
Aromaticity0.05
Grand average of hydropathy-0.678
Instability index56.93
Isoelectric point9.45
Molecular weight82850.19
Publications
PubMed=28385833

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13112
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.52|      38|      44|     354|     396|       1
---------------------------------------------------------------------------
  354-  396 (54.17/49.56)	NEYFAGPDMlEKLKIQSQRyvEYLNNVT........RFNSspAMGNASFVP
  397-  442 (66.35/40.93)	NNFNNSPQM.GNLNIYPQG..QGVNAVPssqqntgrPYNN..AMPQTHNIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     218.33|      44|      45|      78|     121|       2
---------------------------------------------------------------------------
   78-  118 (70.41/31.63)	........QFRTIQ.....SQRAAGQPQ....QQQQQ...QQ....QQQQQQQ..QQGMLNMSGMSQ
  119-  166 (53.18/21.89)	GSN...mpQ.QTQP.....SQQPMGQRS....VNQSQaflAQ....QAQARHQaaQQ..LRSSQQSQ
  167-  214 (50.80/20.55)	VPNnssaaNF.........NQMNRGQPQnpniQLSNA...NA....GNKTNAS..SQGA.NMGGQAQ
  227-  274 (43.94/16.67)	.........MRTVRippaiLNKIPGLPP....NTNTW...QQvfelATQLAQS..QQSPMS.SNLTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.06|      25|      44|     444|     474|       3
---------------------------------------------------------------------------
  450-  474 (45.65/32.59)	KVQPAP...........TPSSIASAPTPGSAAATAN
  593-  628 (35.41/12.55)	KNSPFPktmltpsailqTPLTFSNAKTPGSTSKAAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.33|      23|      44|     664|     690|       4
---------------------------------------------------------------------------
  664-  690 (33.68/31.91)	VATFKSVseiqKVTLDSG..SDADALIPT
  711-  735 (35.66/23.11)	VATFKSI....KLSDDNKffNERDEELPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.29|      17|      25|     304|     321|       5
---------------------------------------------------------------------------
  304-  321 (24.91/22.87)	EKANELLNPLFsMIDHLV
  332-  348 (29.38/21.35)	EGTKKLLHMRF.MIKEVI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13112 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAANPGNVDIQKLKNSAEEIERQCFESSPAR
2) KAQTQQFRTIQSQRAAGQPQQQQQQQQQQQQQQQQQGMLNMSGMSQGSNMPQQTQPSQQPMGQRSVNQSQAFLAQQAQARHQAAQQLRSSQQSQVPNNSSAANFNQMNRGQPQNPNIQLSNANAGNKTNASSQGANMGGQAQPMPTSQSELNNLMR
3) LTFSNAKTPGSTSKAANGTMPASAMHLSSPK
4) PQMGNLNIYPQGQGVNAVPSSQQNTGRPYNNAMPQTHNIPHAIAPQQKVQPAPTPSSIASAPTPGSAAATANQKKPPAKRKSKAAAAAAPKKTSAASTPAIPSKSIATPDVSGSDSNSNASQSHLVKREQDIVNKEALSAKH
27
73
612
403
58
228
642
544










Molecular Recognition Features






MoRF SequenceStartStop




1) FNERD
2) KPPAKRKSKAAAAAAPKK
726
477
730
494