<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13101

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMLGSSRTPLGGTRPKSHQAQQARDELISGRYNLTHPTAVYPLDSNAPNGKQRFPDFQPWKHSIDEDLIAESHLQKGFFEAPHVGNELLSARNIMHQLLRSENSLDELSSNLLKSINVHTLNTKIGPGSYKPPPRVTLTDQKREAWLRDLSQEDVPLRKLARTIPHGIRNKPLLDQCLSKNIPINRAIWLVRCVGTNELRQLKRKGGANIEIQWVQEWTRQVLEFIEKLSQDYLNFESFHRATSLLSSADITVTDSKLNEETKQELLQQFKSLIVDSFNQSVDNFVLPSNWRQLEPTLKTLLNLNDPLISKRFELISYRNQSLMINYSLDKDVSYKDIVTLFDSLGTTTTTSDVVGAMLTGDWRINVNHMLRWTITKYRHDYSRIFFTADVLKKMKSGSQISSKDMEIEILSFVLDVPHLLSQIVLKNLFLLLNELSRLKLFKVSTYMRRLISSGLIYQTNNATEKQIHASILKNLRPQKSSQAVMILKNLETEKDKLGYNPEEKLKAASNLLNGLEDFFTDTEKVSYLEGLDVGLKLEVSDAYISGLLANENLFPLLTFKEFHRIVKTELFLHDLRGLFTFVMKGLESKTLEEAVVLLICDIFTTFKRVVKNITQWDAMCRLLVDNAIMMDSLKCLKKVSALLKGDPLAESLYEETESLVKAKSTHLDTVAITNSLLESGVSLQTDQLLQESNLNHCFQVLIRAFFTDNEAQRSKSAILFLLNVLKDLHTTEFNRALFVYIKKTYSNPAELFKHEPLVDLVVTDLLQLETLATMFIGFRSTVHTGIVLDVLFKDLTQTTSPEHLKLELLRSRVKVESPSLILNLFKESLAESDQKLDSIQSDSAEIISKLLPENKSNNYRSELFTCFIDILVHDRALVVTMLESLDLNSRDVLVDLLIGAITSNTDRIDTDEAGNSYSQLADLVKKLDRFNLEVFQVLLRLKLNSNTSSQELLSSLEQIITESTNKEKFFGSMFELLDASLKTKLLHQFEAMFLSSPTFPSVVQNNQVVSLEVLTDTLITLSRGCEVVPLPDEMLFSLDVSLESLIRVVSQTENSFDDLHTAIALFLKILIIHKTSLINVVIERNTIKESFLNNLVNLLSTKIVSQNLQLKNLLYDLILSIKASVNELNSSQSTMVKLPLSIMNLPAISPADNTHASTSQLKQNLHDFSITQNLYLFSKMPPAYHEMHLKPFDLVEDSNVVENMNDTAIGLQLFEAAMEKRNPS
Length1224
PositionKinase
OrganismCyberlindnera fabianii (Yeast) (Hansenula fabianii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Phaffomycetaceae> Cyberlindnera.
Aromaticity0.07
Grand average of hydropathy-0.132
Instability index36.76
Isoelectric point5.96
Molecular weight138986.25
Publications
PubMed=28385833

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13101
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.96|      25|      31|     764|     794|       1
---------------------------------------------------------------------------
  764-  794 (31.12/39.78)	DLLQLETLATmfigfRSTVHT.GIVLDvLFKD
  802-  827 (35.83/23.75)	EHLKLELLRS.....RVKVESpSLILN.LFKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.48|      39|      59|     944|     982|       2
---------------------------------------------------------------------------
  944-  982 (62.99/41.18)	NSNTSSQELLSSLEQIITESTNKE..KFFGSMFELLDASLK
 1005- 1043 (53.22/33.54)	NNQVVSLEVLT..DTLITLSRGCEvvPLPDEMLFSLDVSLE
 1072- 1099 (35.26/19.50)	IHKTS....LINV..VIERNTIKE..SFLNNLVNLL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      19|      34|     350|     369|       4
---------------------------------------------------------------------------
  350-  369 (29.21/29.01)	TSDVVGAMLTGDwRINVNHM
  387-  405 (31.91/23.62)	TADVLKKMKSGS.QISSKDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.49|      13|     323|     233|     245|       5
---------------------------------------------------------------------------
  233-  245 (23.77/13.43)	LNFESFHR..ATSLL
  557-  571 (19.72/ 9.95)	LTFKEFHRivKTELF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.36|      43|     235|     450|     493|       6
---------------------------------------------------------------------------
  450-  493 (68.26/46.19)	LISSGLIYQT.........NNATEKQIHASILKNlRPQKSSQAVM....ILKNLE.TE
  676-  732 (56.09/33.21)	LLESGVSLQTdqllqesnlNHCFQVLIRAFFTDN.EAQRSKSAILfllnVLKDLHtTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.37|      24|      70|      90|     116|       8
---------------------------------------------------------------------------
   90-  116 (33.14/28.33)	ARNIMHQlLRSENSLDE.LSSNLlkSIN
  160-  184 (40.23/23.16)	ARTIPHG.IRNKPLLDQcLSKNI..PIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.62|      27|     262|     597|     625|       9
---------------------------------------------------------------------------
  603-  632 (44.66/30.48)	FTTF......KR..VVKNITQWDAMCR.LLVDnaiMM..DS
  864-  901 (25.96/21.81)	FTCFidilvhDRalVVTMLESLDLNSRdVLVD...LLigAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13101 with Med12 domain of Kingdom Fungi
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