<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13098

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMMESGASHFQSTNHHRNNGTLTNGARDSPNGLVSHAENQSAAGTNAVLNGNASDSQSPAPFTSRMNDLPDEIQHITQGFVPLSVLLSRLAQQTHNQIGDEIMALAKMPVPSSTMNGNTLSADTSDDNSPDNLNKKVRLLNFVQERHGEWVKALVIANWSRKAEPVSKLIDLMHHINKTRATYQGSLDYMINIKRDLTYARIPNPDLRTALQVLSTGQSPWMPELNYIQPRQITPEEKMRWIENLNTLLSIRLNLEDHENIPEQFQDFEINSGRVTFKVPGEFEVDLTIADEDPEKQFWFIDFRFAFQPAPSELSDRLRDFLEWKVNEALQRDGLIGCYKFLHEFILTHKITEYVRQAMDLSKGRWADMLEVERLRRAMAIHYWSGRQPLDGPQSYIIIGVSSGNIPGLVPSRSISSRLTLRWFRDGIEVKDAQFPLDNETISTEILLNQVIGKHIEHILRKFHDAMKSQGRFLRREASLGISIGESTPRESALTMQLSHEQYLNIKIAPITGTFLAIPQSRGSFDLQSQLNKDVRRPITEQVALLERFRCFFVEDELNRRGKSRGWSVCNPHPAKHEETRQFLGTRGSYQLIWLLRRGLPDNWYIMVGQSLSGDQWCLAEVVKSSGNAKITTHARLPLSPSTPRYSDKFFAELTFFSSAVMSQIGILGAMHKERIKYGIQDRINPMLPPNMKVPSIHVRLSEILGRHHPHINKNISSWAFDFVEINVKNIETRLPQLPGLTVDPGSGSKDEGSAPSALEQHRYNIVVDARVKVADPSRFGLLKGNVERDVAFNERLGVFAFIIEVEVGSSILDMLTHRLQALGRLAGSIDTIRQSRRDIQCEEITLNNVKFSYTDQARPASIKTQQNVQRWAASLDLQTDNMKLILDLGNPQIRATEQFNKLINSNEGFKGVPWFLSITLPIHRALNSVEKAWEPLIMTGQCRVNVSVISLDCYTVQYILGSVKDVGRRLTLYIKVQNHNVKPECHIYRQEIGPNKQPEDEFQKVLQKLWMSDKRVWRYLGASVAADVTSAAEQLIKATDEAVRPLAAVRSPSVSKQSQPKAATAKNVSQNKTAGASKPRPQQTGSVGQVVISLDD
Length1101
PositionTail
Organismfungal sp. No.14919
KingdomFungi
LineageEukaryota> Fungi.
Aromaticity0.07
Grand average of hydropathy-0.403
Instability index55.04
Isoelectric point8.77
Molecular weight124297.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13098
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     515.71|     184|     350|     370|     579|       1
---------------------------------------------------------------------------
  370-  579 (258.63/264.88)	WA.DMLEVE......RLRR..AMAIHYWSGRQplDGPQSYIIIGVSSGNIpgLVPSR.SIS..SRLTLrwFRDGIEvKDAQFpldNETISTEILLNQV.IGKHIEHILRkfHdAMKSQGRFlrrEASLGiSIGESTpRE...SALTMQLSHEQYLNiKIAPIT.GTFLAIPQSRGSFDLQSQLNK...DVRRPiteQVALLERFRCFFVEDElnrrG.KSRGW..SVCNP.HPA
  723-  930 (257.08/179.96)	WAfDFVEINvknietRLPQlpGLTVDPGSGSK..DEGSAPSALEQHRYNI..VVDARvKVAdpSRFGL..LKGNVE.RDVAF...NERLGVFAFIIEVeVGSSILDMLT..H.RLQALGRL...AGSID.TIRQSR.RDiqcEEITLNNVKFSYTD.QARPASiKTQQNVQRWAASLDLQTDNMKlilDLGNP...QIRATEQFNKLINSNE....GfKGVPWflSITLPiHRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.09|      14|      28|      75|      88|       2
---------------------------------------------------------------------------
   75-   88 (25.88/16.15)	DEIQHITQGFVPLS
  104-  117 (25.21/15.56)	DEIMALAKMPVPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.78|      48|      76|     192|     244|       3
---------------------------------------------------------------------------
  192-  244 (69.26/78.92)	DYMINIKRdLTYaRIPNpDLRTALQVlsTGQSP....WMPELNY.IQPRQITPEEKMR
  271-  323 (75.52/59.68)	DFEINSGR.VTF.KVPG.EFEVDLTI..ADEDPekqfWFIDFRFaFQPAPSELSDRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.78|      23|      26|      12|      37|       7
---------------------------------------------------------------------------
   12-   34 (43.19/32.33)	SHFQSTNHHRNNGTLTNGARD..SP
   39-   63 (34.59/16.40)	SHAENQSAAGTNAVLNGNASDsqSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.54|      43|      59|     962|    1004|       8
---------------------------------------------------------------------------
  962- 1004 (75.89/45.88)	QYILGSV.KDVGRRLTLYIKVQNHNVKPECHIYRQEIGPNKQPE
 1023- 1066 (63.64/37.40)	RYLGASVaADVTSAAEQLIKATDEAVRPLAAVRSPSVSKQSQPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13098 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVRSPSVSKQSQPKAATAKNVSQNKTAGASKPRPQQTGSVGQVV
2) DEIMALAKMPVPSSTMNGNTLSADTSDDNSPDNLNKKVR
3) VIMMESGASHFQSTNHHRNNGTLTNGARDSPNGLVSHAENQSAAGTNAVLNGNASDSQSPAPFTSRMNDLPD
1052
104
4
1096
142
75










Molecular Recognition Features






MoRF SequenceStartStop




1) SQPKAATAKNVSQNKTAGASKPRPQQTG
1063
1090