<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13084

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTDNNGMPLLLDSDMSGMDQPPMQVDLNGVDDLFGDTDPLSLPSRPPSRRLRRRLDELRGRGCCQGLAWSKGGTIASITQGGQSLELRYLRANPRDANWELSESKVVTPWQNLNGGPVVHLSWGPASSELAVIDAVGRVLLLNFNSDLNRPLISRRWDGDAIDDLQTIVGTYWLNQLPANSRFYPTYCPAVKSAKGTDYTFENSGVPTMGPNHPNPTKSAFICVTTNGLLKMFWNQNNNKAEETTLELESATSADDLITHAAVCSDKTKSIYIAMATTSKQLRVVQVAIAFSTPKSDNPQNVPPGGNVLSPSLGKRHVAVTSWFQTGICESPLDASMSKISHIEMLPAHFDFQTKQWSPIVVITVRSFVPEPNSPYGQEVQSIIDRWELLTDQKQTVHPAFERLGARRNSVGSTPPATARLKKLDSIIVNKIVMGINVLSFGKILSFYYNDGTVEYRDRFTMHELYREVNLDRIYSILEAGFNQSGEPSCLQMAFSPANYSLVQMYEDGQIKWHNIEYTLGDPATISDGHLSAVIAACAMSTAAATNNNSNIDDVLAVARKFPNRDQFAMKWVTDLVQIMRITVDYSEDVPHDHLIRNQHLQFCFSIFNHLGWSGEFNARHFRSKLSTLALSLRNTVILVSLASSAPSAVRAASSPLDEPEVVNSLAGCARWSIDFLGWLCDALFCLLDDTKFMSFLNQANQSQQLVNMTRYLNAKNEIALHLILCSSTRNLISAVCRRVGLLDGYALRALAWYSGRPEITDPSTSRHVALHAAYRKVHRYTSSALIKADEFDKFLATLAVDIRSAYGTSLGPLAEREAQKAAKNPPTPNQNPNAPKPDRVKEARQHCELNMLLVHPPPPSFLAVITKLFRQDLMGFRASVDIAKLYFADYHILEIIDTPEALEDRKKRGMNVDMFRRIEISKQAQVPWRRCSRCGNIMEDLTSVNNKPGMIFLLAQQRTCCCGGRLALLP
Length971
PositionTail
Organismfungal sp. No.14919
KingdomFungi
LineageEukaryota> Fungi.
Aromaticity0.08
Grand average of hydropathy-0.236
Instability index46.43
Isoelectric point7.78
Molecular weight108101.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364149

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13084
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.51|      13|     511|     383|     395|       1
---------------------------------------------------------------------------
  383-  395 (24.55/18.10)	IIDRWELLTDQKQ
  896-  908 (22.96/16.41)	IIDTPEALEDRKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.18|      35|     156|     485|     521|       5
---------------------------------------------------------------------------
  485-  521 (57.46/42.76)	SGEPSCLQMAFSPANYSLVQMYEDGQIKWhNIEYtLG
  644-  678 (61.72/36.61)	SSAPSAVRAASSPLDEPEVVNSLAGCARW.SIDF.LG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.92|      18|     105|     457|     474|       7
---------------------------------------------------------------------------
  457-  474 (32.71/25.73)	RDRFTMHELYREVNLDRI
  565-  582 (33.21/26.25)	RDQFAMKWVTDLVQIMRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.65|      19|     682|      53|      72|      10
---------------------------------------------------------------------------
   53-   72 (32.43/29.81)	RRLDELRGRGcCQGLAWSKG
  738-  756 (35.22/25.24)	RRVGLLDGYA.LRALAWYSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13084 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTDNNGMPLLLDSDMSGMDQPPMQVDLNGVDD
1
32










Molecular Recognition Features






MoRF SequenceStartStop




1) RRLRRRL
49
55