<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13077

Description mediator of RNA polymerase II transcription subunit 12-like isoform X1
SequenceMQRYSATSCGGVSSTAVGGASARDSARADPSFSSSNFSLNTRRPLQLNPYKLKCDKEPLNCRLGPPDFYPQSPNCPEETLTREYVQSGYKETIEGLEEARELILSQLTTFTKPVIIKCKEAIRKRLRAINDSRAQKRKAGQVYGVPLSGSLLLKPGVFPEQRACGEDSRKKWIEGLSQQHKRLRALADHVPHGFRRKALFEVLIRHNVPLLRATWFIKVTYLNQVRPVSANVSSGATDKTQLNRSDLWTKDIIEYLQYLLDEYISKDGSLGRDQSPQMLLAGSVHKGDSTPTLTDDEEPSLHFKWWYMVRILQWHHAEGLVLPSHIIEWVLSQLQDKESLETLQLLLPIIYAMIETIVLSQTYVRNLVEVAVRSIQEPSSGGSDLVDNSRRAYTASAVIEMLRYLIVAVPDTFVALECFPLAPSVISGVTNGRSFFSKASEDSEKTHYGPGELITMYGDRRQDAHNQFLSFDYLVSSIQKRADNLGKAVSPGLQGHGVAKAVQALDKALTLGDLRGAYNFLFENLCDGNIEEVWIAEVSPCLYSSMKWMGMVSFSFICSLFFLFEWATCDFRDCRTSLPLDLKFTGRKDFSQVYIAVLLLKMKMEDMCNSIQSKNGSTLGAGIFSGGTTGENVFVSKNKSKSLGGRIDSSDIFQSPGPVHDIIVCWIDQHDVGKGEGFKRLQLLIIELIRSGIFYPPAYVRQLIVSGIMDRSETLVDLDRRKRHYHVLKQLPGAYMLDSLEEAQIADVPVLEEALHVYANERRLLLLGLLGDHTSHSKNGNDVSFFSPKQKDNPSSGRNAASPSLEHLKNLRSASNPLSGRDAKMKVQVSEVKAAISMLLHLPSSYSAASDTRSDESQWSCKRSIGPISNKMDVTEGTPGCEECRRSKKQKLSEDRSSYTHGFLQNPSDDEDSWWVRKGPKSMESFKVDPPLKSTKHASRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTGTEGDVSKPSDGMRTAHLGDVVSIGKALKQLRLLEKRAITVWLITSVRQLIEGFEKSISKVGQCTGPLPSSIDDKNSVRWKLTEDELSAILYLMDISFDLVSAVKFLLWLLPKIPSTTNSNIHSGRSILMLPKNTECYSCEVGEAFLLSSIRRYENIIVAADLLHETLSATMHRAATVMTTNGRASGSAAFVYARNLLKKYCNVPSVAKWEKNFRATSDQRLLAELESGRALDGEFGFPLAVPAGVEDLDDYFRQKISGRLSRPTPGMKEIVQKHIDEAMHYFYSKERKLFTAGAPKGPSLEKCDDGYQMAQQIVLGLMECIRQNNNAPQEVDPFVVASAVSAIVGNVVSALVKMPDFTTSSNYPNFPSPINSLNCARRIVHIHIACLCLLKEALGERQSRVFEIALATEASSAVATALAPGKGSRSQFQLSPEAHDSNSSLSNEMLNTAKVFLGRATKAAAAVSSLVVGAVVHGAASLERMISVLRLKEGLDIIQFVRSARTSSNGISRSIGALKVDNLIEVYLHWFRLLVGNCRMVSDGLVVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALVIWRPYILNSNIVIREDVQLHQSLASTINDVIRHQPFRDVCLRDTHAFYDILASDVGDSEFAAMLEMHGTDKHMKTMAFVPLRARLFLNAILDCKLPHSMSSHDDGTRVSGHGELKVQRAESETKLQDQLLHVLDTLQPAKFHWQWVELRFLLNEQALIEKIDTHNMSLAEAIRSLSPSADNSVLSENESNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLQTKWFLGGNDVLFGRKSIRQRLVNIAQIRGLSTKIQFWKPWGWPHSAADLAVIRGEKKKFEVASLEEGEVVEEGVDFKRSGRLTSQTFDSEGFNCGQQYATERSLVELVLPCIDRSSSESRNAFASDLIKQMNGIEQQINAVTRGTGKQAGAVPSGIEGGTNKGSSRKGIRGGSPGLGRRSTGPTDSALPSSAALRASMWLRLKLLLRLFPLIYADRDSSGRNMRLLLSSAILRLLGSRVVHEDADLSYPTQRSSPSKREVESPIEPSAVISLDLCGDSLFDWLLAMLHGLLSSCKPSWLKPKSVSKSTVKSPRDISVFDREAVESLQNELDRMQLPESIRWRLQAAMPILPPCSSFSISCQMPAVSTAALALLQSSFSVPMFQHGTSNLPQKNQVPSARTPASIPGKSKPLPSQDQDMEIDPWTLLEDGTSSGPSSNNCSLGATADHSNLKACSWLRGAVRVRRTDLTYIGAVDDDS
Length2265
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.230
Instability index54.05
Isoelectric point8.55
Molecular weight250702.69
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13077
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     345.74|     110|     345|     326|     442|       1
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  209-  297 (109.92/73.34)	.......................PL.LRA...TWFIKVTYL.N....QVRPVsANVSSGATDKTQLNRSDLWTKDIIEYLQYLL....DEYISKDgslGRDQSPQmLLAGsVHKGDSTPTLTDDE
  326-  442 (169.54/138.37)	IIEWV.LSQLQDKESLETLQLLlPI.IYAMIETIVLSQTYVRNLVevAVRSI.QEPSSGGSDLVDNSRRAYTASAVIEMLRYLIvavpDTFVALE...CFPLAPS.VISG.VTNGRSFFSKASED
  663-  721 (66.29/39.67)	IVCWIdQHDVGKGEGFKRLQLL...iIELIRSGIFYPPAYVRQLI...VSGI.MDRSET...LVDLDRR........................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     458.10|     146|     345|     843|    1007|       2
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  846- 1007 (236.79/200.94)	YSAASDTRSDESQWSCKRSIGPISNKMDVtegtP.GCEECRRSKKQKLSEDRSSYTHG...FLQNPSDDEDSWWVRK........GPKSmesfkvdPPLKSTKHASRGRQKIV.......RKTQSLAQLAAARIEGSqgaSTSHVCDNKIS....CPHHRTGTE.GDVSKPSDGMRTAHlgDVVSI
 1197- 1366 (221.31/144.96)	FRATSDQRLLAELESGRALDGEFGFPLAV....PaGVEDLDDYFRQKISGRLSRPTPGmkeIVQKHIDEAMHYFYSKerklftagAPKG.......PSLEKCDDGYQMAQQIVlglmeciRQNNNAPQEVDPFVVAS...AVSAIVGNVVSalvkMPDFTTSSNyPNFPSPINSLNCAR..RIVHI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.18|      41|     343|    1424|    1480|       3
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 1424- 1480 (54.74/84.19)	SLSNEMLNTAKVFLgratkaaaavsslvvGA..VVHGAASL.ERMISVLRLKeGLDI.IQF
 1780- 1824 (57.44/46.96)	SLEESLLLQTKWFL...............GGndVLFGRKSIrQRLVNIAQIR.GLSTkIQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.69|      15|      17|     478|     492|       4
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  459-  472 (18.47/ 9.82)	.DRRQDAHNQFLSFD
  478-  492 (24.26/15.51)	IQKRADNLGKAVSPG
  498-  512 (20.96/12.27)	VAKAVQALDKALTLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.40|      22|     208|     513|     542|       5
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  513-  542 (29.19/40.27)	DLRGAYnflfenLCDgNIEEVWIAEVsPCL
  730-  751 (40.22/24.08)	QLPGAY......MLD.SLEEAQIADV.PVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.74|      14|      17|     772|     785|       6
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  772-  785 (25.43/14.68)	DHTSHSKNGNDVSF
  792-  805 (24.31/13.68)	DNPSSGRNAASPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.06|      66|     994|    1065|    1135|      10
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 1065- 1135 (100.05/80.51)	LTEDELsaILYLMDISFDLVSAVKfLLWLLPKipSTTNSNIHSGRSILMLPKNT.ECYSCEVGEAFLLSSIR
 2062- 2128 (113.02/72.77)	LCGDSL..FDWLLAMLHGLLSSCK.PSWLKPK..SVSKSTVKSPRDISVFDREAvESLQNELDRMQLPESIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      16|      17|      27|      42|      11
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   27-   42 (27.00/14.04)	RADP.SFSSSNFSLNTR
   46-   62 (25.25/12.65)	QLNPyKLKCDKEPLNCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.45|      15|      17|      69|      85|      12
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   69-   85 (24.97/22.07)	YPQSPNCPEEtlTREYV
   89-  103 (24.49/14.37)	YKETIEGLEE..ARELI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.34|      36|     143|    1551|    1588|      15
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 1551- 1588 (54.49/49.02)	LPPAYSIFALVIWRpYILNSNIVIrEDVQLH.QSLASTI
 1697- 1733 (60.85/43.15)	LQPAKFHWQWVELR.FLLNEQALI.EKIDTHnMSLAEAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13077 with Med12 domain of Kingdom Viridiplantae
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