<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13073

Description mediator of RNA polymerase II transcription subunit 15a-like
SequenceMSSISGEVSSRDIRPGGRSSNLEIPNLHSLQITSVLLDKYNFREWSISAMLFITSRDLTVQHFPTTAKIWEKVSKTYGQKKNNARIYRLNQDIAALRQGDMTVATYFATLEGLWEELDHHLILDWENARDKERHDKNIEESKTFTFLVGLDPVYEGIRSQILGRDELPELHHVYYLVRNEEVRRKEMQVDSQIQPVEQFGEHSALISTKGNKHPDKKHLKCTHCGGERHVKEKCWVLYPHLKPAALRKDKKQQKGHAASGNLVTSNNGDNSQSIPTVASSPMGQVADSSGAGALGFTASEVEVLSRALARLRNNYFASTSLASQEIAERLEQKIYTTAESKDDYEKRIYANLSMIWTKPQNTDTNNFVPSNSAASNPNPQDLASQYTPSQVDKQGQSLVVPLANQSQACPQLFSESIQNTIASTGVQSSTGLASGLPSLTDLTQNSISIVGSQNSNLQNISEISQNETNHSVGQGMISNIFGNSQRQMHGRQHLPQKHQQQSQNPQQHIYQQKQLQNQLFKQKLHHGNIQPTLIQSHIQQQQQNLLEPNQVKPSQESLVQSSSGFQSNQSTVQQTQPSEMQSPCSDHQQNQQSSVQQSMASMLQQHSQSILSQQQQLQQSVHQRTPFAYQQQATMSQQLMLPPQKQNLLIGQQSVSNLQHNQLLGHQSSVGDLQQQQQQQQQQQQMLLSLPNNLPDILQQQQFLSWQNNNSNLHEQQLVSQSKFSGLQQKQLLGPQSGLSNMQQHQTSVHILQQAKAASAHQQQIQQMSATSLPSQGQQSQSQTPQQQLISQFQSQTAQLQQELGFQQQSNSLQRDMQQKFQTSSTLHHPQNVMEQQKQLFQSQRVLPEVSSTPIDSTAQTGHLNDSDWQEKMFQKFHVEAKGLWGYLDGSVSKPDDSDIKGLNQWKIDNAKFASQIVG
Length919
PositionTail
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.05
Grand average of hydropathy-0.823
Instability index65.68
Isoelectric point7.08
Molecular weight103431.51
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13073
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     377.73|      43|      43|     599|     641|       1
---------------------------------------------------------------------------
  384-  413 (35.86/ 7.59)	.............S..QY....TPSQVDKQ...G.....QSL..........VV..PLANQSQ.A..CPQL.F
  495-  546 (44.98/11.49)	.PQKH.QQQ....S..QNpqqhIY.QQKQL...QnqlfkQKL....H..H..GNiqPTLIQSH.IQQQQQNLL
  555-  595 (50.10/13.68)	QESLV.QSS....SgfQS....NQSTVQQT...Q.....PSE....M..Q...S..PCSDHQQ....NQQSSV
  599-  641 (79.51/26.27)	MASML.QQH....S..QS....ILSQQQQL...Q.....QSV....H..Q..RT..PFAYQQQ.ATMSQQLML
  645-  688 (43.66/10.92)	KQNLLiGQQ....S..VS....NL.QHNQLlghQ.....SSVgdlqQ..Q..........QQQ.QQQQQQMLL
  694-  722 (36.36/ 7.80)	LPDIL.QQ........QQ....FLSWQNN....N.....SNL....H..E..........QQ...LVSQS...
  725-  771 (40.33/ 9.50)	..SGL.QQKqllgP..QS....GLSNMQQH...Q.....TSV....HilQqaKA..ASAHQQQ...IQQMSAT
  773-  806 (46.93/12.32)	LPSQG.QQ.....S..QS....QTPQQQLI...S.....Q...................FQSQtAQLQQELGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.33|      29|      42|      57|      93|       2
---------------------------------------------------------------------------
   57-   85 (52.00/41.83)	DLTV.QHFPTTAKIWEKVSKTYGQKKNNAR
  100-  129 (49.32/23.85)	DMTVaTYFATLEGLWEELDHHLILDWENAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.42|      17|      37|     417|     446|       4
---------------------------------------------------------------------------
  434-  451 (24.29/26.78)	SGLPSLTDLTQNSI.sIVG
  455-  473 (23.13/ 8.28)	SNLQNISEISQNETnhSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.63|      24|      30|     813|     842|       5
---------------------------------------------------------------------------
  823-  849 (35.55/18.17)	TSSTlhhPQNVMEQQKQLFQ..SQRVLPE
  850-  875 (38.08/14.87)	VSST...PIDSTAQTGHLNDsdWQEKMFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.59|      17|     141|     271|     290|       6
---------------------------------------------------------------------------
  271-  290 (21.57/21.44)	SQSIP.TVASSpmGqVADSSG
  414-  431 (26.03/12.76)	SESIQnTIAST..G.VQSSTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13073 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHQQQIQQMSATSLPSQGQQSQSQTPQQQLISQ
2) FKQKLHHGNIQPTLIQSHIQQQQQNLLEPNQVKPSQESLVQSSSGFQSNQSTVQQTQPSEMQSPCSDHQQNQQSSVQQSMASMLQQHSQS
3) LGFQQQSNSLQRDMQQKFQTSSTLHHPQNVMEQQKQL
4) LRKDKKQQKGHAASGNLVTSNNGDNSQSIPTVASSPMGQVA
5) QNSNLQNISEISQNETNHSVGQGMISNIFGNSQRQMHGRQHLPQKHQQQSQNPQQHIYQQKQLQNQ
6) QNTDTNNFVPSNSAASNPNPQDLASQYTPSQ
760
520
804
246
453
360
792
609
840
286
518
390










Molecular Recognition Features






MoRF SequenceStartStop




1) LNQWKIDNAKFASQIVG
2) VEAKGLWGYLD
903
879
919
889