<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13056

Description mediator of RNA polymerase II transcription subunit 15a-like
SequenceMASFTSVYISEQMPTIWSTSVDFADLTMGQQNNLSNMHQKQLGPQSNISGLQQQQQQLVGTQLGNSSMQTNQQSLHMLSQPKVALQQTQQTAPNLLPTQGQTSQQPQQEQQLMSQMQSQPTQLQQQLGLQQQPNQVQQNMQQTLQASGQTSSSLLQLYQSQRAVLETSTTSLDSTAQTGHSNGGDWQEEVYQKIKAMKETYFSELNEMHQKIAAKLLQHDSLPQQPKSEQLEKLKIFKTMLERILHFLTVSKANIVPAFKDKLSSYEKQIIYFINTNRPRKPVSALQQGQLPPPHMHSMQQPQPQSNQTQSHDNQMNPQLQSINLQGSMPTMQPNNMTSLQHNTLSSLPGVSTAQQTMLNSLQPGSNLDPGQGNALGSMQQVAPGPLQQNPASTSQQANLNSLSSQSGLSVLQQNMNPLQSNSNMLQHQHMKQQQEQQILQSQKYKQQLQQQRQMQHQIMQQKHQLMQQQQQQAKQQLPTQLQAHQMPQLHQMNDVNDMKQGISVKPGVFQQHLPAGQRQTYTHQQLKPGVQFPISSPQLHPAASPQMPEHSSPQIDQQSLLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPAPGTSSLSNAANIGHQQGTGVQAGSQSLAIGTPGISASPLLAEFTDGTHANVLTTVSSKSNITEQPLERLMKAVKSMSPTALCASVSDIGSVVSMTDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITQDGMSGSKKMRRHTSAMPLNVVSSVGSINDSFKQLTGSETSDLESTATSTVKRPRIEANHALLEEIREINQQLIDTVVDISDEDVDPGTVATAAEGGEGTVVKCSFNAVALSSNLKSQYMSAQMSPIQPLRLLVPTNYPNCSPVLLDKFPVEVSKEYEDLSVKAKSKFSISLRTLSQPMSLGEIARTWDVCARAIISEHAQQSGGASFSSKYGTWENCSMAA
Length953
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.03
Grand average of hydropathy-0.614
Instability index65.36
Isoelectric point7.74
Molecular weight104143.91
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13056
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     307.83|      44|      47|     448|     491|       1
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   67-  108 (59.45/16.89)	S...MQTNQQ...SLHML......SQP.KVAL..QQTQ..QTAPNLLPTQGQ.T.....SQQPQ.Q
  109-  158 (53.22/14.23)	E...QQLMSQ...MQSQP......TQL.QQQLgLQQQP..NQVQQNMQQTLQ.AsgqtsSSLLQLY
  322-  371 (35.91/ 6.83)	S...INLQGSmptMQPNN......MTSlQHNT.LSSLPgvSTAQQTMLNSLQ.P.....GSNLDPG
  372-  417 (39.24/ 8.25)	QgnaLGSMQQ...VAPGP......LQQ.NPAS.TSQQA..NLNSLSSQSGLS.V.....LQ.QNMN
  450-  491 (74.14/23.17)	.....QQQRQ...MQHQI......MQQ.KHQL.MQQQQ..QQAKQQLPTQLQ.A.....HQMPQLH
  492-  541 (45.88/11.09)	Q...MNDVND...MKQGIsvkpgvFQQ..HLP.AGQRQ..TYTHQQLKPGVQfP.....ISSPQLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.66|      15|      15|     570|     584|       2
---------------------------------------------------------------------------
  543-  557 (19.25/ 6.10)	AASPQMPEHS.SPQID
  575-  590 (21.41/ 7.69)	ANSPFVVPSPsTPLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.21|      25|      73|     201|     227|       3
---------------------------------------------------------------------------
  201-  227 (40.85/22.77)	YFSELNEMHQKIAAklLQHDSLP.......QQPK
  272-  303 (34.36/14.20)	YFINTNRPRKPVSA..LQQGQLPpphmhsmQQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.78|      87|     114|     609|     722|       4
---------------------------------------------------------------------------
  609-  722 (108.55/127.75)	NAANIGHQQGtgvQAGSQSLAIGTpgiSASPLlaeftdgthaNVLTTVSSK....................SNITEQPLE...RLMKAVKSMSpTALcasvsdIGSVVSMTDRiaGSAPGNGSRAAV.GEDLVamTKC
  725-  835 (126.23/78.23)	QARNFITQDG...MSGSKKMRRHT...SAMPL..........NVVSSVGSIndsfkqltgsetsdlestatSTVKRPRIEanhALLEEIREIN.QQL......IDTVVDISDE..DVDPGTVATAAEgGEGTV..VKC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13056 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPVSALQQGQLPPPHMHSMQQPQPQSNQTQSHDNQMNPQLQSINLQGSMPTMQPNNMTSLQHNTLSSLPGVSTAQQTMLNSLQPGSNLDPGQGNALGSMQQVAPGPLQQNPASTSQQANLNSLSSQSGLSVLQQNMNPLQSNSNMLQHQHMKQQQEQQILQSQKYKQQLQQQRQMQHQIMQQKHQLMQQQQQQAKQQLPTQLQAHQMPQLHQMNDVNDMKQGISVKPGVFQQHLPAGQRQTYTHQQLKPGVQFPISSPQLHPAASPQMPEHSSPQIDQQSLLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPAPGTSSLSNAANIGHQQGTGVQAGSQSLAI
2) VGTQLGNSSMQTNQQSLHMLSQPKVALQQTQQTAPNLLPTQGQTSQQPQQEQQLMSQMQSQPTQLQQQLGLQQQPNQVQQNMQQTLQ
281
59
630
145










Molecular Recognition Features






MoRF SequenceStartStop




1) KQIIYFIN
268
275