<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13053

Description mediator of RNA polymerase II transcription subunit 8-like
SequenceMEGMIQDPSQPASQPQQQNQAVVGAERLNQALQQQLNLESVKTRAISLFKAITRILEDFDAYSRTNTTPKWQDILGQYSMVNLELFNIVDEIKKVSKAFVVHPKNVNADNAPILPVMLSSKLLPEMEVEDNLKREQLLLGMQNLPIPSQIDKLKARIDMIAAACESAEKVLADTRKAYCFGSRQGPAILPTLEKGQAAKIQEQENLLRTAVNFGEGLRLPADQKLITPSLPLHLVDIMPATDGVQSFADPSGMYMKNTPLMSNNIGSQGTLLQATGAQLIGRSAASPSAATSATSYDNTTTSPLPYANSPRSATTMMNTPSPQQQTQQLQQQQQHQQQQQQQRQKMMQLPQHQQQLLAQQQFRQSTMQGLGQNQLPLHDLQGQTQQKFQSLHGQMQFSQPLGHQQFQGRQLPPGHVQHGIGQSQLNQGNQLSRHLGQFSSAANTALFNAAQGTPSTQMIPNMSATMSSQSLLPRMQFGLPGSNPQRTHASQILSDQMFNMGSNPGGLMAMQPQPQQQQQQSQQQHGSQAAFGNMGTAQNLQSNMAALQNNPNFAQQRQQNQQ
Length562
PositionHead
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.04
Grand average of hydropathy-0.643
Instability index60.27
Isoelectric point9.11
Molecular weight61902.12
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13053
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.87|      95|     189|     186|     374|       1
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  186-  315 (117.73/51.74)	PaiLPTLeKGQA.AKIQEqenlLRTAVNFGEGL........RLPAD..QKLITPS.......LPLHLvdimpatdgvQSFADPSgmymkNTPLMsnNiGSQGTllqaTGAQLIgrsaasP..SAATSATSYDNTTTSPLPYANSPRSATT
  376-  490 (145.14/67.15)	P..LHDL.QGQTqQKFQS....LHGQMQFSQPLghqqfqgrQLPPGhvQHGIGQSqlnqgnqLSRHL..........GQFSSAA.....NTALF..N.AAQGT....PSTQMI......PnmSATMSSQSLLPRMQFGLPGSNPQRTHAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.41|      24|     189|     316|     374|       2
---------------------------------------------------------------------------
  340-  372 (33.96/12.80)	QQQrqkmmqlpQHQQQL....LAQQQFRQSTMQGLgQ
  521-  548 (37.46/13.64)	SQQ........QHGSQAafgnMGTAQNLQSNMAAL.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.85|      14|     223|     318|     331|       3
---------------------------------------------------------------------------
  318-  331 (29.26/ 8.25)	NTPSPQQQTQQLQQ
  549-  562 (27.58/ 7.39)	NNPNFAQQRQQNQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.16|      18|     498|       1|      20|       4
---------------------------------------------------------------------------
    1-   20 (33.21/18.69)	MEGMIQDPS.....QPasQPQQQNQ
  497-  519 (32.95/13.36)	MFNMGSNPGglmamQP..QPQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.38|      17|      18|     117|     133|       5
---------------------------------------------------------------------------
  117-  133 (28.41/16.30)	MLSSKLLPEMEVEDNLK
  138-  154 (28.97/16.76)	LLGMQNLPIPSQIDKLK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13053 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAQLIGRSAASPSAATSATSYDNTTTSPLPYANSPRSATTMMNTPSPQQQTQQLQQQQQHQQQQQQQRQKMMQLPQHQQQLLAQQQFRQSTMQGLGQNQLPLHDLQGQTQQKFQSLHGQMQFSQPLGHQQFQGRQLPPGHVQHGIGQSQLNQGNQLSRHLGQFSSAANTALFNAAQGTPSTQMIPNMSATMSSQSLLPRMQFGLPGSNPQRTHASQILSDQMFNMGSNPGGLMAMQPQPQQQQQQSQQQHGSQAAFGNMGTAQNLQSNMAALQNNPNFAQQRQQNQQ
276
562










Molecular Recognition Features






MoRF SequenceStartStop




NANANA