<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13050

Description mediator of RNA polymerase II transcription subunit 19a-like isoform X1
SequenceMDAGGNKFGGGPRELSGVVDLISRYKLLPHHDFFCKRPLPLSIADTHYLHNVAGDTEIRKGEGMQLDQLNQNTSHNRDTNARIQPFDFDILKEAFQLRETTPVELPPTEKGMPTIAGKSKGEVKDKERKHKKHKDRDKEKDKERKKHKHCHKDKDRSKDKDKEKKKDRNGHHGSGADHLKKHHEKKRKHDGDEVRNDINRHKKSKKMGVGRAFGWHERFSC
Length221
PositionHead
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.05
Grand average of hydropathy-1.507
Instability index34.75
Isoelectric point9.72
Molecular weight25620.65
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13050
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.28|      23|      33|     147|     178|       1
---------------------------------------------------------------------------
  147-  174 (34.22/27.71)	HkhchKDKDRSKDKDkEKKKDRNGHHGS
  182-  204 (40.06/11.53)	H....HEKKRKHDGD.EVRNDINRHKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.68|      13|      14|     118|     130|       2
---------------------------------------------------------------------------
  118-  130 (22.97/12.14)	KSKGEVKDKERKH
  134-  146 (22.71/11.92)	KDRDKEKDKERKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13050 with Med19 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRETTPVELPPTEKGMPTIAGKSKGEVKDKERKHKKHKDRDKEKDKERKKHKHCHKDKDRSKDKDKEKKKDRNGHHGSGADHLKKHHEKKRKHDGDEVRNDINRHKKSKKMGVGRAFGWHE
2) VAGDTEIRKGEGMQLDQLNQNTSHNRDTNARIQP
97
52
217
85










Molecular Recognition Features






MoRF SequenceStartStop




1) GADHLKKHHEKKRKH
2) RKKHKHCHKDKDRSKDKDKEKKKDRN
175
144
189
169