<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13016

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMQRYHGAGCTSAVNNSAIGGASARDTSRADSSSLPPNFQFNSRRQSQLASYKLKCDKEPLNCRLGPPDFHPQSQTCPEETLTRENVQQGYKDTINGLEDSKEISLTQIQAFTKPVVLKCRDAIRKCLRAINETRAQKRKAGQVYGIPLSGSLLSKPGVFPEQRPCSEDFRKKWIEGLSQQNKSLCSLADQVPLGYKNRTLIEVLIRNNVPLLRATWFIKVTYLNQVRPGSAISTGSLDKAQLSRTELWTKDVIDYLQHLLDEIFSRNNSHFTQHGRDRLPQMHNAASLQHRSAPASATLDGEEPSLQFKWLYVVRLLQWHHAEGLVLPSLIIDWVLNQLQEKELLEILQLLLPIVYGVLETVILCQTYVRNLVAIAIRFIREPSPGGADLVDNSRRAYTVSALVEMLRYLIQAVPDTFVALDCFPLPTCVVSHAFSDGGFLSKSSDDAGKIKSNSADAYVVKVKGFDSQYQSLSFDHVVSTIHKCADNLAKGASAGYPSQSMAKAVQTLDKALLHGDLIEAYKHIFDDLCDGAVGEGWVAEVSPCLRSSLKWLQTVNLSLICSVFFLCEWATCDFRDFRTAPPHNLKFTGRKDFSQIYLAIHLLKLKREEWQNPEYKRGRASGLYSTAKNTSYQNNYSRRNLLGNIYEAKSNGKYVNGRSSSSSDIFDSPGPLHDIIVCWIDQHEGLKGEGGKRLQLLILELIRSGIFYPQAYVRQLIVSGIIDISRPMADLDRRKRHHRILKQLPGQYMLDILEEARIAKGSELLEAVNVYSNERRLALHNLLFDQHNCANTSHVSTNDKKSHSTSGRDGAFQVSGDQWKTLQSSKTFRRDVDLEGLKASISVLLQFPSLSSTSADSGVEESQGSSKRSVGSTCNKPDMFEGAPGYEDRKRVKRQKLSEDKSLYLQAPSPIPSDDEDTWWMRKGQKNIESFKSDPPHKSTKQVSRGRQKTVRKTQSLAQLAAARIEGSQGASTSHICDNKINCSHHRTEVETLKPVDGIRTTHFGDIVSIEKGLKQLRFVEKRIVMVWLISVVKQLVEESEKSVAKAGQYGRPFIAADEKSPLRWKLGEDELSVILHLMDVSCDSVSAIKFLLWLLPIVSSNPGPTVHSGRNSLRVPRNVDNCACAVGEAYLLSSLRRYENILIAADLVPEALSAIMLRAAAIMATNGRVTGSGTLVFAWYLLKKYGKVASVIEWEKKYKGACDKRLFSELESGQQEGDFGFPFGVPGGIEDPDDYFRKKITGGRFLRVGLSMRDMVQRHVDDVLHSILGKERKLVAAGAPKTPAVEKGGDGYQVAQQIIMGLMDCIRQTGGAAQEGDPGLVSSAVSAIVGNVGSTLAKIPDFTGGSNYSNYQPSISSLSFAKRILRIHLICLCLLKEALGERQSRAFEVALGTEASSALAVAFAPAKSSRGQFKLSPDAPESSANISGDNLNSSAKSTLGRTTKMSAAISALLLGAVVHGVISLERMVTVLRLKEGLDVVQFVRSTKTSSNGNARSVGAFKLDNSFEIYVHWFRLFVGNCRTVCDGLVLELLGEQPIVALSRMQRLLPINLVFPPAYAIFAFVIWKPFILSSNIASREDIHQLYQSLTMAIGDAVKHIPFRDVCMRDTRGFYDIIAADTTDSEFAALLELNGLDTHLKSMAFIPLRARLFLNAIIDCKMPYSAFTHDEGNWVSGHGESKALRGENDSKQGKLIRALDALQPAKFHWQWVELRLLLNEQALIDKMENHDMSLVDALRSSSPSSERASPSENEKVFIEIILTRLLVRPDAAPLFSEVVHLFGRSLEDSLLMQAKWFLGGMDVLLGRKTVRQRLINIAETKNLSTKTQFWKPWGWSYSGGDPVTNRGEKKNEATFLEEGEVIEEAVESKKCAKGSQIDVEGSNISQQHVTEKAFIKLILPCIDQSSADSRNTFANDLIKQFSTIEQQVKLVTRGISKQTGTASSIEVSTNKSNSRKSIRGASPGLARRTMAPAESVPPSPAALRASMSLRLQFIVRLLPIICADGEPSSRNMRHMLASVILRLLGSRVVHEDVDLSFNFKQLKRDAELVSSIASSEIYRDSLFDRLLLVLHGLLSSCQPSWLRSKTANDFSGFDHEALESFQNELDSMQLPEIIRWRIQAAMPILFPSFRNVISCHTPSVPVGALSALQSSIYIPESCNGTLNAPQRQVASARTANNIPGKAKSMPSLQEYDMEIDPWTLLEDGAGSSLSSSGTIVIGGSDRANLRASSWLKGAVRVRRADLTYTGAVDDGS
Length2251
PositionKinase
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index48.85
Isoelectric point8.87
Molecular weight249178.66
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13016
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.61|      28|     298|     572|     599|       2
---------------------------------------------------------------------------
  572-  599 (54.14/30.76)	TCDFRD.FRTAPP.HNLKFTGRKDFSQ...IYL
  874-  906 (37.47/19.08)	TCNKPDmFEGAPGyEDRKRVKRQKLSEdksLYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.62|      56|    1148|     787|     848|       5
---------------------------------------------------------------------------
  787-  848 (84.12/72.07)	QHNCANTSHVSTNdkKSHSTSGRDGAfqVSGDQWKTLQSSKTFRRDVdlEGLKASISVLLQF
 1937- 1992 (95.50/61.56)	QTGTASSIEVSTN..KSNSRKSIRGA..SPGLARRTMAPAESVPPSP..AALRASMSLRLQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.63|      50|    1153|     365|     473|       6
---------------------------------------------------------------------------
  366-  420 (72.25/102.38)	QTYVRNLVAIAIRFIREPSpggADLVDNSRRAYTVSALVEmlRYLIQAVPDTFVA
  711-  760 (85.38/24.16)	QAYVRQLIVSGIIDISRPM...ADLDRRKRHHRILKQLPG..QYMLDILEEARIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.48|      26|      98|    1324|    1381|       7
---------------------------------------------------------------------------
  468-  493 (47.33/16.82)	SQYQ....SLSFDHVVSTIHKCADNLAKGA
 1351- 1380 (41.15/17.43)	SNYQpsisSLSFAKRILRIHLICLCLLKEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13016 with Med12 domain of Kingdom Viridiplantae
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