<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13003

Description mediator of RNA polymerase II transcription subunit 16-like isoform X2
SequenceMNQQPGLGDNKESEEEPVAQPVDSAVKLGLEKPVGSEPVSGVAEDEVVVSSSGKSEDTVMEEDPVNPATVFCIWLKQPKSNLRYKMRVPELCRNFSAVAWCGKLNAIACATETCARIPSSNANPPFWIPIQIVIPERPTECAVFNVTADSPRDSVQFIEWSPTSCPRALLIANFHGRVTIWTQPSQGPAHLVRDASFWKREHEWRQDIAVVTKWLSGVSPYRWLSSKSINPANSKSTFEEKFLSQQSQNSARWPNFLCVCSVFSSGSVQLHWSQWPPTQGSVARKWFCTSKGILGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTVVVWEVTPGTGNGFQATAKTSTSNGIPPSVNPPNWAGFAPLAAYLFSWQEYLISEAKQGKKTADQDFNDVVSLHCSPVSNFSAYVSPEAAAQSAATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPTITGWRVQRWESSLQPVVLHNIFGNPSSSFGGQAPKQTVWLSKVDTSIPPTNDFKSHQAAAAGPTSDSRKASDSSSEKLKRVSFDPFDLPSDVRTLARIVYSAHGGEIAISFLRGGVHIFSGPNFSAVDNYQINVGSAIAAPAFSSTSCCSASVWHDTSKDRTMLKIIRVLPPAISSSQIKANSSTWERAIAERFWWSLLVGVDWWDAVGCTQRAAEDGIVSLNSVIAVLDADFHSLPSIQHRQQYGPSLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALVNPSALVSEPWQASGETLSSIDPEAMAVDPALVQSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAVTAGTGSNRNMVTSPTQSSATPATSQAGQSGTTSSTGSTQMQAWVQGAIAKISGSTDGVSTSTPNTISGPSSFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFFFRRALQPRFAQRNTDANPQKNQPGAPGKMEEVNSVAAKPTTMTRPDEAHGARAGQLVPGAKGAEEGPRGLKIGSGNAGQGYTFEEELCSGVPSNI
Length1025
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy-0.187
Instability index42.34
Isoelectric point6.26
Molecular weight109968.46
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13003
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.82|      19|      21|     833|     853|       1
---------------------------------------------------------------------------
  835-  853 (33.66/21.78)	PTQSSATPATSQ...AGQSGTT
  855-  876 (29.16/11.56)	STGSTQMQAWVQgaiAKISGST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.63|      21|      23|     160|     181|       3
---------------------------------------------------------------------------
  160-  181 (37.32/21.29)	WSPTSCPrALLI..ANFHGRVTIW
  184-  204 (29.02/11.97)	..PSQGP.AHLVrdASFWKREHEW
  659-  668 (22.30/ 7.59)	WS.......LLV..G.....VDWW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.78|      17|      19|     788|     804|       4
---------------------------------------------------------------------------
  788-  804 (28.66/20.69)	IQAYVDAVLDLASHFIT
  806-  822 (30.12/22.13)	LRRYASFCRTLASHAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.09|      12|      19|       7|      18|       5
---------------------------------------------------------------------------
    7-   18 (20.68/12.21)	LGDNKESEEEPV
   28-   39 (19.76/11.34)	LGLEKPVGSEPV
   54-   65 (18.65/10.29)	KSEDTVMEEDPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.55|      28|     489|      94|     135|       6
---------------------------------------------------------------------------
   68-   89 (26.47/29.15)	..A.TVFCIwlKQPKSN......LRYKMRVP
  108-  135 (56.24/27.59)	ACA.TETCA..RIPSSNANPPFWIPIQIVIP
  342-  361 (26.84/ 7.87)	ATAkTSTSN..GIPPS.VNPPNW........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.29|      10|      18|     753|     762|       8
---------------------------------------------------------------------------
  753-  762 (17.09/ 9.76)	VNPSALVSEP
  773-  782 (18.20/10.92)	IDPEAMAVDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.58|      17|      23|     878|     894|      14
---------------------------------------------------------------------------
  878-  894 (30.73/15.63)	GVSTSTPN.TISGPSSFM
  901-  918 (28.85/14.23)	GTFPGTPAvRLIGDCHFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13003 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FAQRNTDANPQKNQPGAPGKMEEVNSVAAKPTTMTRPDEAHGARAGQLVPGAKGAEEGPRGLKIGSGN
2) GTGSNRNMVTSPTQSSATPATSQAGQSGTTSSTGST
939
824
1006
859










Molecular Recognition Features






MoRF SequenceStartStop




1) GPRGLK
2) NKESEEEPVAQPVDSAVKLGLEK
996
10
1001
32