<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12988

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMAEKQLIVAVEGTAAMGPYWHIVVSDYLDKIIRCFCSSELTGQKNSTSNVEFSLVTFNTHGSYCACLVQRSGWTKDVDIFLQWLSAIPFSGGGFNDAAIAEGLSEALMMFPIASNGNQTPQNVDGQRHCILVAASNPYPLPTPVYRPQIQNLEQVENSEAQTESRLSDAETVARSFAQCSVSLSVICPKQLAKLKAIYSAGKQNPRAADPPVDNVKNSQFLVLISENFMEGRAALSRSGLPSLATNQSPVKMDMASVTSVTGPPPSSVNGSMVGRLPVSVGNVATATVKVEPTTITSMATGPAFSHVPSVPRAPSQAIPTLQTSSPLTNTLEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNILNNLSQARVMSSAALTGGTSIGLQSMVQTPVAMHMSNMISSGMASSVPPAHTVLSSGQPTMTSLTGSGALTGAAQVLPNSGLSSFSSATSNVAGNSNIGISQPMGNVQGAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQTLGVSNSSAASMPLSQQTSSALQSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASETLAAHWPQTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLGQLQEKKLCAVIQLPQQTLLLSVSDKACRLIGMLFPGLHSSNTPPGLHPSLDKPKKLNEMDMVVFKPQMSSQQQLQLQQQQMQPQLQQQQQQQNPQLQQQQLPHLQQQQLPQLQQQQQQQQLPQLQQQQLSQLQQQQQQQKQQQQQQQQSQHPQMQQQQLSQQQQMVGSGMGPAYVQGPG
Length822
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.04
Grand average of hydropathy-0.337
Instability index60.43
Isoelectric point8.75
Molecular weight87907.54
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12988
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.10|      23|      25|     726|     750|       1
---------------------------------------------------------------------------
  726-  749 (41.79/13.73)	...PQLQQQQQQ.QN.PQLQQQQLPhlQQ
  750-  772 (31.94/ 6.15)	QqlPQLQQQQQQ.QQlPQLQQQQL.....
  782-  805 (46.37/12.08)	Q..KQQQQQQQQsQH.PQMQQQQLS..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     244.31|      48|      54|     210|     257|       3
---------------------------------------------------------------------------
  210-  239 (39.52/16.67)	....................................PPVDNV..............KN.S.QFLVLISENFMEGRAALSRS...G
  240-  279 (50.13/23.10)	LPSLATNQSPVKMD......MASV.......tsvtgPPPSSV..............NG.S...........MVGRLPVS......
  280-  337 (44.32/19.58)	VGNVAT..ATVKVEpttitsMATG............PAFSHVpsvprapsqaiptlQT.S.SPLT....NTLEGMT....S...G
  338-  388 (38.24/15.90)	.....DNMQELK.........PSV.sgmtqpsrpvpPAAANV...................NILNNLSQARVMSSAALTGGtsiG
  389-  434 (43.96/19.36)	LQSMV..QTPVAMH......M...snmissgmassvPPAHTV..............LS.SgQP..........TMTSLTGS...G
  443-  471 (28.15/ 9.77)	LPN.........SG......LSSF...........sSATSNV..............AGnS.NI..GISQP..MG...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     214.45|      52|      54|     499|     550|       4
---------------------------------------------------------------------------
  499-  534 (53.49/23.20)	.................................SG..VG.........MSQNMSALGQST......VSSGNGTMIPTPGMSQQVQS
  535-  580 (57.43/25.47)	GMQTLGVSNSSAASMP................lS...............QQTSSAL.QSAqskyvkVWEGN........LSGQRQG
  590-  656 (50.89/21.70)	GYRSASASETLAAHWPqtmqivrlisqdhmnnkQY..VGkadflvfraMNQH.GFLGQ................LQEKKLCAVIQL
  657-  696 (52.64/22.71)	PQQTLLLSVSDKAC.....................rlIG.........ML..FPGLHSSN......TPPGLHPSLDKP........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12988 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KQQQQQQQQSQHPQMQQQQLSQQQQMVGSGMGPAYVQGPG
2) LSRSGLPSLATNQSPVKMDMASVTSVTGPPPSSVNGSMVGR
3) NMISSGMASSVPPAHTVLSSGQPTMTSLTGSGAL
4) TITSMATGPAFSHVPSVPRAPSQAIPTLQTSSPLTNTLEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNI
5) VQGAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQTLGVSNSSAASMPLSQQT
783
235
403
294
473
822
275
436
366
555










Molecular Recognition Features






MoRF SequenceStartStop




1) MVGSGMGPAYVQGPG
2) PQMQQQQLSQQ
808
795
822
805