<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12988

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMAEKQLIVAVEGTAAMGPYWHIVVSDYLDKIIRCFCSSELTGQKNSTSNVEFSLVTFNTHGSYCACLVQRSGWTKDVDIFLQWLSAIPFSGGGFNDAAIAEGLSEALMMFPIASNGNQTPQNVDGQRHCILVAASNPYPLPTPVYRPQIQNLEQVENSEAQTESRLSDAETVARSFAQCSVSLSVICPKQLAKLKAIYSAGKQNPRAADPPVDNVKNSQFLVLISENFMEGRAALSRSGLPSLATNQSPVKMDMASVTSVTGPPPSSVNGSMVGRLPVSVGNVATATVKVEPTTITSMATGPAFSHVPSVPRAPSQAIPTLQTSSPLTNTLEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNILNNLSQARVMSSAALTGGTSIGLQSMVQTPVAMHMSNMISSGMASSVPPAHTVLSSGQPTMTSLTGSGALTGAAQVLPNSGLSSFSSATSNVAGNSNIGISQPMGNVQGAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQTLGVSNSSAASMPLSQQTSSALQSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASETLAAHWPQTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLGQLQEKKLCAVIQLPQQTLLLSVSDKACRLIGMLFPGLHSSNTPPGLHPSLDKPKKLNEMDMVVFKPQMSSQQQLQLQQQQMQPQLQQQQQQQNPQLQQQQLPHLQQQQLPQLQQQQQQQQLPQLQQQQLSQLQQQQQQQKQQQQQQQQSQHPQMQQQQLSQQQQMVGSGMGPAYVQGPG
Length822
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.04
Grand average of hydropathy-0.337
Instability index60.43
Isoelectric point8.75
Molecular weight87907.54
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12988
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.10|      23|      25|     726|     750|       1
---------------------------------------------------------------------------
  726-  749 (41.79/13.73)	...PQLQQQQQQ.QN.PQLQQQQLPhlQQ
  750-  772 (31.94/ 6.15)	QqlPQLQQQQQQ.QQlPQLQQQQL.....
  782-  805 (46.37/12.08)	Q..KQQQQQQQQsQH.PQMQQQQLS..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     244.31|      48|      54|     210|     257|       3
---------------------------------------------------------------------------
  210-  239 (39.52/16.67)	....................................PPVDNV..............KN.S.QFLVLISENFMEGRAALSRS...G
  240-  279 (50.13/23.10)	LPSLATNQSPVKMD......MASV.......tsvtgPPPSSV..............NG.S...........MVGRLPVS......
  280-  337 (44.32/19.58)	VGNVAT..ATVKVEpttitsMATG............PAFSHVpsvprapsqaiptlQT.S.SPLT....NTLEGMT....S...G
  338-  388 (38.24/15.90)	.....DNMQELK.........PSV.sgmtqpsrpvpPAAANV...................NILNNLSQARVMSSAALTGGtsiG
  389-  434 (43.96/19.36)	LQSMV..QTPVAMH......M...snmissgmassvPPAHTV..............LS.SgQP..........TMTSLTGS...G
  443-  471 (28.15/ 9.77)	LPN.........SG......LSSF...........sSATSNV..............AGnS.NI..GISQP..MG...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     214.45|      52|      54|     499|     550|       4
---------------------------------------------------------------------------
  499-  534 (53.49/23.20)	.................................SG..VG.........MSQNMSALGQST......VSSGNGTMIPTPGMSQQVQS
  535-  580 (57.43/25.47)	GMQTLGVSNSSAASMP................lS...............QQTSSAL.QSAqskyvkVWEGN........LSGQRQG
  590-  656 (50.89/21.70)	GYRSASASETLAAHWPqtmqivrlisqdhmnnkQY..VGkadflvfraMNQH.GFLGQ................LQEKKLCAVIQL
  657-  696 (52.64/22.71)	PQQTLLLSVSDKAC.....................rlIG.........ML..FPGLHSSN......TPPGLHPSLDKP........
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12988 with Med25 domain of Kingdom Viridiplantae
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