<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12986

Description pre-mRNA-processing protein 40A-like isoform X1
SequenceMANNSQPSSAQPHWPPAVGSMGPQSYGSPLSSQFRPVVPTQQGQHFVPAASQQFRPVGQVPSPNIGMPAVQNQQMQFSQPMQQFPPRPNQPGLSTPSQQPIQVQYGQTNRPLTSEPPQSHQSAPPLNSHMPGVGAPGVPPSSYGFAPSSFGLPQNNVSAPSQFHPMSQVHAPVAPVAGQPWLSTGNQNVSLATPTQHTSQQPPPSSADTNANVPSLTPQSSDWQEHTSADGRRYYYNKRTRQSSWEKPLELMTPIERADASTVWKEFTTPEGRKYYHNKVTKESKWTIPEELKLAREQAQAAASQGTPSGSGVAPQAPVATAVSAAETPTTAIPVSSNTLQDSSPVSVTPVANPSPTSVSGPTTGPVAQSAAMSATGVQLPVVSVTPVPAVPSRGSTVPAPSVGANTAVTRSSETTSTQDTMHFADGASAQDIEEAKKGMATAGKVNMTPVEEKVPDDEPLVYANKLEAKNAFKSLLESANVQSDWTWEQTMREIINDKRYGALKTLGERKQAFNEYLGQRKKLEAEERRMRQKKAREEFTKMLEESKELTSSMRWSKAQSLFENDERFKAVERARDREDLFENYIVDLERKEREYAAEEKRRNIAEYRKFLESCDFIKANSQWRKVQDRLEDDERCSRLEKIDRLLIFQDYIHDLEKEEEEKKKMQKEQLRRAERKNRDAFRKLMEEHVADGTLTAKTYWRDYCLKVKELPQYLAVASNTSGSTPKDLFEDVAEELDKQYHEDKTRIKEAMKTGKVTMVYSWTFEDFKTAISEDVGSSSISDINLKLVYDELLERAKEKEEKEAKKRQRLADDFTRLLHTYKEITASSNWEESKPLFEESQEYRSIAEESFRREIFEEYITHLQDKAKEKERKREEEKAKKEKDREEKDKRKEKEKERKEKEREREREKGKDRTKKDETDSENLDISDSYGHKEEKKKEKEKDRKHRKRHAADDGSSDKDDREESKKSRRHGSDRKKSRKHAHSPDSDSESRHRKHKRDHRDGSRRNSGYEELEDGELGEDGEIQ
Length1026
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.06
Grand average of hydropathy-1.165
Instability index59.11
Isoelectric point6.72
Molecular weight116553.75
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
U1 snRNP	GO:0005685	IBA:GO_Central
U2-type prespliceosome	GO:0071004	IBA:GO_Central

GO - Biological Function
RNA binding	GO:0003723	IBA:GO_Central

GO - Biological Process
mRNA cis splicing, via spliceosome	GO:0045292	IEA:InterPro
mRNA splicing, via spliceosome	GO:0000398	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12986
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     153.52|      28|      30|     863|     890|       1
---------------------------------------------------------------------------
  837-  861 (27.45/ 7.94)	................LFEESQE....YRSIAEES.......FRREIFEEYI
  862-  889 (44.29/16.50)	T..............HLQDKAKE...KERKREEEK.......AKKEKDREEK
  890-  917 (30.92/ 9.70)	D..............KRKEKEKErkeKEREREREK.......GK...DRTKK
  918-  966 (24.75/ 6.57)	DetdsenldisdsygHKEEKKKE...KEKDRKHRKrhaaddgSSDKDDREES
  967-  996 (26.10/ 7.25)	K..........ksrrHGSD..RK...KSRKHAHSP.......DSDSESRHRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     245.22|      36|      38|     216|     251|       2
---------------------------------------------------------------------------
  117-  156 (25.23/ 7.46)	..P.....QS.....HQSAPplnshmpgvgapgvpPSSYGFA....PSSFGLPQNN
  163-  191 (40.17/15.84)	FHP.....MSQVHAPVAPVA...............GQPWL.......STGNQNVSL
  192-  215 (27.58/ 8.77)	ATP...tqHTSQQPPPSSAD...............TNA............NVP..S
  216-  251 (64.72/29.62)	LTP.....QSSDWQEHTSAD...............GRRYYYNKRTRQSSWEKPLEL
  252-  292 (52.23/22.61)	MTPieradASTVWKEFTTPE...............GRKYYHNKVTKESKWTIPEEL
  297-  329 (35.28/13.10)	EQA.....QAAASQGTPSGS...............GVAPQAPVATAVSAAETP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.01|      14|      17|      24|      37|       3
---------------------------------------------------------------------------
   29-   48 (20.66/ 8.43)	PLSSQFRPVvptqqgQHFVP
   80-   91 (22.25/ 9.67)	PM.QQF.PP......RPNQP
  125-  138 (20.09/ 7.99)	PLNSHMPGV......GAPGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.41|      22|      22|     525|     546|       4
---------------------------------------------------------------------------
  508-  544 (24.50/ 8.70)	GErkqafneylgqrkklEAEERRMRQKKAREEFTKML
  613-  640 (21.51/ 6.83)	ES.........cdfikaNSQWRKVQDRLEDDERCSRL
  667-  686 (20.55/ 6.23)	.................QKEQLRRAERKNRDAFRKLM
  799-  819 (30.84/12.65)	EK...............EEKEAKKRQRLADD.FTRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.58|      21|      36|     345|     365|       5
---------------------------------------------------------------------------
  356-  381 (22.96/12.06)	PTSVSGPTTGPVaqsaamSATGVQL..P...
  414-  434 (25.91/14.69)	ETTSTQDTMHFA......DGASAQD..I..E
  435-  459 (21.71/10.94)	EAKKGMATAGKV......NMTPVEEkvPddE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.62|      14|      25|      66|      79|       6
---------------------------------------------------------------------------
   66-   79 (27.30/19.62)	GM..PAVQNQQMQFSQ
   92-  107 (22.33/14.51)	GLstPSQQPIQVQYGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.02|      27|      65|     577|     603|       7
---------------------------------------------------------------------------
  510-  557 (18.43/ 6.76)	.RKQAFNEYLG..QRKKleaeerrmrqkkareeftkmleesKELTSSMRWS
  558-  576 (29.43/15.24)	KAQSLFEN...D....E........................R.FKAVERAR
  577-  603 (47.45/29.13)	DREDLFENYIVDLERKE........................REYAAEEKRR
  644-  665 (35.71/20.08)	DRLLIFQDYIHDLEKEE.............................EEKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.31|      10|      36|     346|     355|       8
---------------------------------------------------------------------------
  346-  355 (20.12/11.91)	VSVTPV.ANPS
  383-  393 (15.19/ 7.20)	VSVTPVpAVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.78|      31|     276|     468|     498|       9
---------------------------------------------------------------------------
  468-  498 (52.03/30.89)	EAKNAFKSLLESANVQ...SDWTWEQTMREIIND
  709-  732 (31.91/16.24)	......KELPQYLAVA...SN.TSGSTPKDLFED
  743-  775 (42.85/24.20)	EDKTRIKEAMKTGKVTmvyS.WTFEDFKTAISED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12986 with Med35 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KAKEKERKREEEKAKKEKDREEKDKRKEKEKERKEKEREREREKGKDRTKKDETDSENLDISDSYGHKEEKKKEKEKDRKHRKRHAADDGSSDKDDREESKKSRRHGSDRKKSRKHAHSPDSDSESRHRKHKRDHRDGSRRNSGYEELEDGELGEDGEIQ
2) MANNSQPSSAQPHWPPAVGSMGPQSYGSPLSSQFRPVVPTQQGQHFVPAASQQFRPVGQVPSPNIGMPAVQNQQMQFSQPMQQFPPRPNQPGLSTPSQQPIQVQYGQTNRPLTSEPPQSHQSAPPLNSHMPGVGAPGVPPSSYGFAPSSFGLPQNNVSAPSQFHPMSQVHAPVAPVAGQPWLSTGNQNVSLATPTQHTSQQPPPSSADTNANVPSLTPQSSDWQEHTSADGRRYYYNKRT
3) VQLPVVSVTPVPAVPSRGSTVPAPSVGANTAVTRSSETTSTQDTMHFADGASAQDIEEAKKGMATAGKVNMTPVEEKVPDDEPLVY
4) WEKPLELMTPIERADASTVWKEFTTPEGRKYYHNKVTK
5) WTIPEELKLAREQAQAAASQGTPSGSGVAPQAPVATAVSAAETPTTAIPVSSNTLQDSSPVSVTPVANPSPTSVSGPTTGPVAQSAAMSAT
867
1
378
245
286
1026
240
463
282
376










Molecular Recognition Features






MoRF SequenceStartStop




1) GYEELED
2) KDDREESKKSRRH
3) KEKDRKHRKRHAADD
4) RHRKHKRDHR
5) RKKSRKH
1010
960
941
993
976
1016
972
955
1002
982