<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12982

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFRIGGLSQVSWFQFHPVESDLSSLPDKRIKVEQKDAATLLVLSSHLQLQKEGFLSAWTNSFVGPWDPSQGLHNPDEKIKLWLFIPGRHASVVDSAQSAVSRLRVVASGLWLAPGDSEEVAAALSQALRNRIERALLGLSYMRFGDVFSRYHPPQIEESIRRAQPTIEFIFAATEESIFVHAIISSKHIRTLSTGDIEKVLEHSSNNTSYLLPVIISPHGMCGKLTGCCPNDLVKQVYFSNSGKIGLPHRTSQSSGCQLRGQNCYVKVSLGCSKSRGDKSLNQNPDYIRNLPKHQSTEAYAMGRVDQKGPLDLLSVHEKTFIYPPEAVLVPVLQTSFARSSLRRFWLQNWIGPSLAGSSFFRHCFCSDGNLDILEKSWAEFSGIHTQHCYNSSSNSNNSSISSLSSSSSDSVTTGARDLEADADSSCRQSGLSSNDQMETDCLKMGSKRPRIGMTESYGQAGTVTNAPTEDVYKSNIRSMEVNRSVITGVGNDQIGSNWDWDDDDRGIVMDIQSLLSEFGDFGDFFENDVLPFGEPPGTAESSAIMFGASDCGDVGSSPAGVMDTSDQMLLPVGLPSFDSFNPPLPVVTEEFLSKSQEVTNSAVTSGPSNQTPASSTGEFDHLMKAEALMTFAVEYGAVETPASDSSSGFRNPXLPKSRKVESSNSIQSNSKYAATPPSFPCFGGLDEKTGMPMNLKAHPGGHDSNAMLQLKKYYTHVETREERYSRRLLTHNDSNATNEMSGTSQFGNLYSINSDKSASRKMTQGVFGGERILQSMKTVLGTEVECSMFQASMLRMRHILLSPTSPATISLSRPTASSVLNQLPDDPSTMADNLSSRYEVKKESIPFKSAGDIDGVMLDGHLNAPVGVWRTVGAPKVSKLATSSIEASPSLTHNLYNEESMLSYGQSQPLQELLDGIPLLVQQATSFVDLALDADGGDCPYSWLALQEHWRRGFCCGPSMVHAGCGGTLASCHSLDIAGVELVDPLSANVSFLHCRDSSSTVTLSVGEAVSPSQTSVGGSSYLKDGGKVDETSQRRLNQETSGSELEQQQSSRLRPTLFVLPSPALLVGYQDDWLKTSGNSLQLWEKAPLEPYALPKPINYSVICPDIDPLTSAAADFFQQLGIVYETCKLGTHSPQSLGNQMEIDSGKWFSSGFVLLDCPQSMKIESSNASLLGSISDFFLSLSNGWDMTCYLKSLSKALKALKIGQFLFTNQKEGISSPCLVIYVVCPFPEPTAVLKTVIESSIAVGSIILPSDRDKRSLLHSQIGKALSSSAAADEASVSNIPVVSGFSVPKVVVQIVTVDAIFRVTSPPFNELVILKEMAFTVYNKARRISRGSMNDLALSSSLSRSHSVLTPMTSIPTMWKDSVGSRIPGSSITREGEIDSSLRGGAWENSWQTRTGGLICDPNRNGDFFYPDEVRFMFEPLFILAESGSLEHGVSPTAFGNSTSETSKIVSDESGGGFMQAANSVGTDPGSGSQHVGLEPDGLDSSNQKIPSLHCCYGWTEDWRWLVCIWTDARGELLDCNIFPFGGISSRQDTKGLQCLFVQVLQQGCQILQACTSSDTGVVKPRDFVITRIGSFYELEYLEWQKAIYSVGGSEVKKWPLQLRRSVPDGMPANTNGASLDQQEMSLIQERTLPSSPSPLYSSHTKASFMKGGLGQPAARKQLLSGQTLVDNSRGLLQWVQSISFVSVSVDHSLHLVLQADSPSSGTHSGTGPGQSSYIEGFTPVKSLGSTSASYMLIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTGFVVSKAVPSMRKDYRNHPKEEWPSVLSVSLIDYYGGNKVTQDKVIRGIAKQAGRTPSSESRDSEIDNHLILASIAAELHALSWMTVSPGFLDRRTALPFHTDMVLRLRRLLHFAEKELSGQPDKSQV
Length1918
PositionKinase
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy-0.245
Instability index51.04
Isoelectric point5.70
Molecular weight208294.30
Publications
PubMed=25893780

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     988.34|     290|     508|     958|    1302|       1
---------------------------------------------------------------------------
  356-  651 (384.70/186.51)	GPSL..AG.SSFFRHCFCSD.GNLDILEKSWAEFSGIhtqHCYNSSSnSNNSSISSLSSSSSDSV..TTGARD.LEADADSSCRQSGLSSNDQMETdclKMGSK.RprigmtesygqagtvtnaP.TEDVYKSNIRSMEVNRSVITGVGND......QIGSNWDWDDD......DRGIVM.DIQSLL..SEFGDF....GDFFENDVLPFGEPPGTAESSAImfgasDCGDVGSSPAGVMDTSDQMllpvglpSFDSFNPP.LPVVTEEFLSKSQEVTNSAVTSGPSNQTPASSTGEFDHLMKAEA.....LMTFAV....EYGAVETPASDSS..................................................................................
  962- 1302 (431.68/309.91)	GPSMvhAGcGGTLASCHSLDiAGVELVDPLSANVSFL...HCRDSSS.TVTLSVGEAVSPSQTSVGGSSYLKDGGKVDETSQRRLNQETSGSELEQ...QQSSRLR..................P.TLFVLPSPALLVGYQDDWLKTSGNSL.....QLWEKAPLEPYalpkpiNYSVICPDIDPLT..SAAADFFQQLGIVYETCKLGTHSPQSLGNQMEI.....DSGKWFSSGFVLLDCPQSM.......KIESSNASlLGSISDFFLSLSNGWDMTCYLKSLSKALKALKIGQFLFTNQKEGisspcLVIYVVcpfpEPTAVLKTVIESS..............................iavgsiilpsdrdkrsLLHSQiGkalsssaaadeasvSNIPVVSGFSVPKVV
 1601- 1798 (171.95/81.30)	...............................................................SVGGSEVKKWPLQLRRSVPDGMPANTNGASLDQ...QEMSLIQ..................ErTLPSSPSPLYSSHTKASFMK.GGLGQpaarkQLLSGQTLVDN......SRGL.LQWVQSISfvSVSVDHSLHLVLQADSPSSGTHSGTGPGQSSYI.....E..........................................................................................................gftpvkslgstsasymlipspsmrflpptplqlptcltaespplahLLHSK.G..............SAIPLSTGFVVSKAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.64|      30|     697|     688|     788|       2
---------------------------------------------------------------------------
  751-  788 (37.33/78.08)	FGNlysinsDKSASRKMTQGVFGGeRILQSMKTVlGTE
 1450- 1479 (52.30/27.16)	FGN......STSETSKIVSDESGG.GFMQAANSV.GTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.71|      18|      43|    1491|    1508|       3
---------------------------------------------------------------------------
 1491- 1508 (36.33/17.63)	PDGLDSSNQKIPSLHCCY
 1535- 1552 (34.39/16.34)	PFGGISSRQDTKGLQCLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.61|      60|    1334|      20|      90|       4
---------------------------------------------------------------------------
   21-   90 (98.97/85.53)	PVESD.LSSLPDkrikveqkDAATLL.VLSSHLQLQKEG..FLSAWTNSF...VGPW..DPSQG..LHNPDEkIKlWLFIP
  819-  859 (43.05/18.30)	PTASSvLNQLPD........DPSTMAdNLSSRYEVKKESipFKSA.........GDI..D.....................
 1397- 1431 (27.59/ 8.58)	............................................AWENSWqtrTGGLicDPNRNgdFFYPDE.VR.FMFEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.04|      27|     508|    1340|    1367|       5
---------------------------------------------------------------------------
 1340- 1367 (43.67/34.12)	SRGSM..NDLALSSSLSRSHSvLTPMTSIP
 1851- 1879 (43.37/28.76)	SRDSEidNHLILASIAAELHA.LSWMTVSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12982 with Med13 domain of Kingdom Viridiplantae
Unable to open file!