<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12980

Description mediator of RNA polymerase II transcription subunit 33A
SequenceMEFSLQSSRLWEEVVEQTKVAKEKGIDPLLWALQVSSSLGTSGIALPSTELAHVLVNYICWDNNIPILWKFLDKALMMKIIPPLLVIALLSQRVIPSRRSHPAAYRLYLELLKRHAFALKCQINGLDYQEVMESIDATLHLSEIFGLQTTEPAILVVEFIFSIVWQLLDASLDDEGLLELTEEKVSRWAIKPQEMEIDGHDMYDEKNIAYCERLQNFNTTMAIEIIGQFLQNKATSRILYLAQRNMSSHWVSFIQSLQLLGANSAALKNSKVLTSEALQELASDSRIFLSRECKTSSRQKFHAVMAFGSLASSVSLCPGASRSDLWLPLDMVLEDAMDGYLVNTTSAVEIITGLTKTLQAINGTNWHDTFLGLWIASLRLVQRERDPIEGPMPRLDTRLCMLLSIMTLVVADLIEEEEGAPTDETEYGSTNHWKEMKFPRKRRADLVSSLQVLGDYQGLLAPPKFVVSAANQAAAKAMLFVSGINVGSAYFECVNIKDMPFSCSGNLRHLIIEACIARNLLDTSAYYWPGYVNGRINQLPYSVPAQAPGWSSFMKGAPLTSVMINALVSSPASSLAELEKIFEIAVNGSEDEKISAATILCGASLIRGWNIQEYTVXXXXXADFTGSDSHLIDYAPMLNVLIVGIASVDCVQIFSLHGLVPQLACSLMPICEVFGSCVPNLSWTLPSGEEISPHAVFSNAFALLLKLWRFNHPPIEHGVGDVPTVGSQLTPEYLLLVRNSHLLSSENTHKDRNKRRLSEVASSSSPEPVFLDSFPKLKVWYRQHQRCIAATLSGLVHGTTVHQTVDRLLNMMFRKINKGSQSITSVTSGSSSSSGAGIEDNSLKPELPAWDILEAVPYVVDAALTACAHGKLSPRELATGLKDLADFLPASLATIVSYFSAEVSRCVWKPVVMNGMDWPSPAANLSNVEEHIKKILAATGVDVPRLSAGGSSPATLPLPLAAFVSLTITYKIDKTSERFLNLAGPALESLAADCPWPCMPIVASLWTQKAKRWFDFLVFSASRTVFLHNSDAIVQLLKSCFTATLGLNIAPISSNGGVGALLGHGFGSHFCGGLSPVAPGILYLRVYRSIRDIVFITEEVVSLLMHSVREIACSGLPKQKLDKLKRSKNGMKYGQVSLAAAMTRVKLAASLAASIVWLSGGHGLVQSLIKETLPSWFISVHRSDRDQGSGLVAMLGGYALAYFIVLCGAFAWGVDSSSSASKRRPKILGSHMEFLASALDGKISLGCDGATWHAYVSGFVSLMVGCTPNWVLEVDVDVLRRLSKGLRQWNEEELALALLGIGGVGTMGAAAELIIEHFDS
Length1320
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy0.172
Instability index48.35
Isoelectric point6.07
Molecular weight143680.36
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12980
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.39|      25|     152|     478|     515|       1
---------------------------------------------------------------------------
  478-  504 (44.52/28.84)	MLFVsgINVGSAYFECVNIKDM....P.FSCS
  637-  666 (35.88/38.80)	MLNV..LIVGIASVDCVQIFSLhglvPqLACS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.04|      40|     147|      78|     120|       3
---------------------------------------------------------------------------
   78-  120 (63.67/45.50)	MKIIPPLL......VIALLSQRVIPsrrSHPAAYRLYLELLKRHAFALK
  223-  268 (62.36/37.09)	IEIIGQFLqnkatsRILYLAQRNMS...SHWVSFIQSLQLLGANSAALK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.77|      59|     147|     971|    1046|       4
---------------------------------------------------------------------------
  971-  991 (15.74/ 6.64)	.....................................................................KIDKT...SERFLNLAGPALESLA
  996- 1046 (44.17/60.04)	W..PCMPIVASLWTQKAKRWFdflvFSAsrtvflHNSDaivQLLKSCFTATLG........................................
 1157- 1236 (85.86/58.51)	WlsGGHGLVQSLIKETLPSWF....ISV......HRSD...RDQGSGLVAMLGgyalayfivlcgafawGVDSSssaSKRRPKILGSHMEFLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.42|      34|     152|    1101|    1142|       5
---------------------------------------------------------------------------
 1101- 1142 (47.38/58.48)	VSLLmhsvreIACSglPKQKL....DKLKRSKNGMK.YGQVSLAAAM
 1260- 1298 (51.03/37.78)	VSLM......VGCT..PNWVLevdvDVLRRLSKGLRqWNEEELALAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.15|      22|     119|     318|     341|       7
---------------------------------------------------------------------------
  318-  341 (33.27/32.02)	PGASRSDLWLPLDmVLEDaMDGYL
  439-  460 (38.89/25.92)	PRKRRADLVSSLQ.VLGD.YQGLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12980 with Med33 domain of Kingdom Viridiplantae
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