<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12980

Description mediator of RNA polymerase II transcription subunit 33A
SequenceMEFSLQSSRLWEEVVEQTKVAKEKGIDPLLWALQVSSSLGTSGIALPSTELAHVLVNYICWDNNIPILWKFLDKALMMKIIPPLLVIALLSQRVIPSRRSHPAAYRLYLELLKRHAFALKCQINGLDYQEVMESIDATLHLSEIFGLQTTEPAILVVEFIFSIVWQLLDASLDDEGLLELTEEKVSRWAIKPQEMEIDGHDMYDEKNIAYCERLQNFNTTMAIEIIGQFLQNKATSRILYLAQRNMSSHWVSFIQSLQLLGANSAALKNSKVLTSEALQELASDSRIFLSRECKTSSRQKFHAVMAFGSLASSVSLCPGASRSDLWLPLDMVLEDAMDGYLVNTTSAVEIITGLTKTLQAINGTNWHDTFLGLWIASLRLVQRERDPIEGPMPRLDTRLCMLLSIMTLVVADLIEEEEGAPTDETEYGSTNHWKEMKFPRKRRADLVSSLQVLGDYQGLLAPPKFVVSAANQAAAKAMLFVSGINVGSAYFECVNIKDMPFSCSGNLRHLIIEACIARNLLDTSAYYWPGYVNGRINQLPYSVPAQAPGWSSFMKGAPLTSVMINALVSSPASSLAELEKIFEIAVNGSEDEKISAATILCGASLIRGWNIQEYTVXXXXXADFTGSDSHLIDYAPMLNVLIVGIASVDCVQIFSLHGLVPQLACSLMPICEVFGSCVPNLSWTLPSGEEISPHAVFSNAFALLLKLWRFNHPPIEHGVGDVPTVGSQLTPEYLLLVRNSHLLSSENTHKDRNKRRLSEVASSSSPEPVFLDSFPKLKVWYRQHQRCIAATLSGLVHGTTVHQTVDRLLNMMFRKINKGSQSITSVTSGSSSSSGAGIEDNSLKPELPAWDILEAVPYVVDAALTACAHGKLSPRELATGLKDLADFLPASLATIVSYFSAEVSRCVWKPVVMNGMDWPSPAANLSNVEEHIKKILAATGVDVPRLSAGGSSPATLPLPLAAFVSLTITYKIDKTSERFLNLAGPALESLAADCPWPCMPIVASLWTQKAKRWFDFLVFSASRTVFLHNSDAIVQLLKSCFTATLGLNIAPISSNGGVGALLGHGFGSHFCGGLSPVAPGILYLRVYRSIRDIVFITEEVVSLLMHSVREIACSGLPKQKLDKLKRSKNGMKYGQVSLAAAMTRVKLAASLAASIVWLSGGHGLVQSLIKETLPSWFISVHRSDRDQGSGLVAMLGGYALAYFIVLCGAFAWGVDSSSSASKRRPKILGSHMEFLASALDGKISLGCDGATWHAYVSGFVSLMVGCTPNWVLEVDVDVLRRLSKGLRQWNEEELALALLGIGGVGTMGAAAELIIEHFDS
Length1320
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy0.172
Instability index48.35
Isoelectric point6.07
Molecular weight143680.36
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12980
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.39|      25|     152|     478|     515|       1
---------------------------------------------------------------------------
  478-  504 (44.52/28.84)	MLFVsgINVGSAYFECVNIKDM....P.FSCS
  637-  666 (35.88/38.80)	MLNV..LIVGIASVDCVQIFSLhglvPqLACS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.04|      40|     147|      78|     120|       3
---------------------------------------------------------------------------
   78-  120 (63.67/45.50)	MKIIPPLL......VIALLSQRVIPsrrSHPAAYRLYLELLKRHAFALK
  223-  268 (62.36/37.09)	IEIIGQFLqnkatsRILYLAQRNMS...SHWVSFIQSLQLLGANSAALK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.77|      59|     147|     971|    1046|       4
---------------------------------------------------------------------------
  971-  991 (15.74/ 6.64)	.....................................................................KIDKT...SERFLNLAGPALESLA
  996- 1046 (44.17/60.04)	W..PCMPIVASLWTQKAKRWFdflvFSAsrtvflHNSDaivQLLKSCFTATLG........................................
 1157- 1236 (85.86/58.51)	WlsGGHGLVQSLIKETLPSWF....ISV......HRSD...RDQGSGLVAMLGgyalayfivlcgafawGVDSSssaSKRRPKILGSHMEFLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.42|      34|     152|    1101|    1142|       5
---------------------------------------------------------------------------
 1101- 1142 (47.38/58.48)	VSLLmhsvreIACSglPKQKL....DKLKRSKNGMK.YGQVSLAAAM
 1260- 1298 (51.03/37.78)	VSLM......VGCT..PNWVLevdvDVLRRLSKGLRqWNEEELALAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.15|      22|     119|     318|     341|       7
---------------------------------------------------------------------------
  318-  341 (33.27/32.02)	PGASRSDLWLPLDmVLEDaMDGYL
  439-  460 (38.89/25.92)	PRKRRADLVSSLQ.VLGD.YQGLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12980 with Med33 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) GHKNPHFKHGNHNRQWANG
2) LHDLPK
3) SLRKPDKMAVPKKPLRSQ
435
426
365
453
431
382