<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12972

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMQRYHAPSCTSAVNNSAIGGASVRDTPRVDSSSLPPNFSLNSRRQSQLAPYKLKCDKEHLNSRLGPPDFHPQTQNCPEETLTRENVQHGYKDTIDGLEDSKEISLTQVQAFTKPVVLKCRDAIRKCLRAINESRAQKRKAGQVYGVPLSGSLLSKPGVFPEQRPCNEDFRKKWIEGLSLQHKPLCSLADQVPQGYKKRPLIEVLIRNNVPLLKATWFIKVTYLNQVRPGSAISSGAPDKTQLSRTELWTKDVIDYLQYLLDEFFSKNNSHSTQHGRDRLPQMHYAGSLQHRSDLAPAIIDGEEPSLHFKWWYVVRLLQWHHAERLVLPSLIIDWVLNQLQEKDLLEILQLLLPIIYGVLETITLCQTYVRNLVGVAIRFIREPSPGGSDLVDNSRRAYTISALVEMLRYLIQATPDTFIALDCFPLPTCVLSHTPSDGGFLSKPSDDAAKKNYSADAYAVRGKGFDSQYHSLSFNHVVSTVEKRADNLAKGATAGYPSQSVAKAVQTLDKALLQGDVIDAYKHIFNDLYDGAVGEGWVAEVNPCLRSSLKWLQTVNLSLICSVFFLCEWATCDYRDFRTAPPSDVKFTGSKDFSQIYLAIQLLKLKMKELQKKLKKERASRKNTSQQNSYSSKDLLGDTHEAKSNGKCLNGRRRNFSDIFDSPGPLHDIIVCWIDQHEGHKGEGSKRLQLFMLELIRSGIFYPQAYVRQLIVSGIVDTNGPMADLNRRKRHQRILKQLPGQFMVNALEEARIAEGSELLEAINVYSNERRLVLQELFFDSYNNTNNSHALAKKLNCHSTSGRDVDSQVSCDKRRTVQASKTFRREVDLEELKASISVLLQFPSSSFCSADSGVDESQGSIKRSIGSTHSKMDSVEGTPGCEDCKRVKRQKLSEDKSSCLQVSSPIPSDDEDTWWVRKGPKNLEGSKVDPLLKSTKQASRGRQKSVRKTQSLAQLAAARIEDSQGASTSHVCDSKISCPHHRTEVENLKPVDGIRTTHHADIISIGRGLKQLRFVEKRVVTIWLLSVVKQLVEESEKSVPKASQYGRPFVAADEKSPLRWKLGEDELSAILYLLDVSCDSASAVKFLLWLLPKAISNPSPAIHSGRNILMVPRNVENYACEVGEAYLLSSLRRYENILIAADLVPEALSATMRHVASFMATNGRITGSGALVFACYLLRRYGSIASVIEWEKNFKGTCDKRLLSELESGRTEGEFGFPHGVPAGTEDPDDYCRQRINVGRLSRVGASMRDMVQRHIDDVLHYILGKERKHFAANAPKSPATEKGGDDYQVAQQIIMALMDCFRQTGGAFQEGDPGLVSSAVSAIVSNVGPTLAKIPDFTSGSTYSNYQPPMNSLNFAKRILHIHLICLCLLKEALGERKSQAFEIALATEAFSALAVAFAPAKSSRGQLLSPDSLDSHTNISNDNSHSSAKATLGRTTKMAAVSALVIGAIIHGVISLERMVSVLRLKEGLDVVQFVRSTKTSSNGNARSVGAFKVDNSVEVYVHLFRLFVGNCRTVCDGLVLELLGEQSVLALSRMQRLLPINLVFPPAYAIFAFMIWKPFILNSNTARSEDIHQLYQSLTMAIGDAIKHRPFRDVCMRDTRGFYDIVAADTIDAEFAAMLELNGLDMHLKSMAFVPLRARLFLNAIIDCKMPNSAFTQDDGNRVSGHSESKALRAETSKLLDKLVCALDTLQPAKFHWQWVELRLLLNEQALIDKIENHDMSLVDAIRSSSPSSERASPSESEKVFIEIILTRLLVRPDAAPLFSEVVHLFGRSLEDSMLMQAKWFLGGLDVLLGRKTVRQRLSNIAENKNLSTKSQFWKPWGWSYSGADPVTNSGEKRKSEVTSLEEGEVIEEGMESKGCVKGSTQVDIEGSGINQQHVTEKAFIELVIPCIDQSSADSHNTFASDLIKQFNTIEQQINSVTRGVSKQTGTATSGIEGPTNKINNRKGIRGGSPGLAKRTPAPVESAPPPSPAALRASMSLRLQFIVRLLPIICADGEPSARSMRNMLASVILRLLGSRVVHEDVDLSSNLAQLKRDMELMPIVASTEMSGDSLFDRLLLVLHGLLSSCKPSWLKSKDAKDFSGFDREAVEGLQNELDSMQLPEMIRWRIQAAMPILFPSFHNTVSCQPPSVPIGALSLLQPSICVPGSYTGTINPPQRQVASARNANNMPGKSKSVLSQENDMEIDPWTLLEYGAGSGPSSSSTAAIGGSDNANLRASSWLKGAVRVRQTDPSYIGAVDDDS
Length2245
PositionKinase
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.07
Grand average of hydropathy-0.280
Instability index48.20
Isoelectric point8.57
Molecular weight248533.72
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      18|      54|     383|     402|       1
---------------------------------------------------------------------------
  383-  402 (30.05/22.86)	PSPGG.....SDlvDNSRRAYTISA
  435-  457 (27.78/14.58)	PSDGGflskpSD..DAAKKNYSADA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.52|      20|      54|     657|     681|       2
---------------------------------------------------------------------------
  657-  681 (32.76/30.16)	SDIFDSPGPLHDiivcwIDQHEGHK
  713-  732 (36.76/19.96)	SGIVDTNGPMAD.....LNRRKRHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.54|      24|      50|     796|     820|       3
---------------------------------------------------------------------------
  796-  820 (39.37/25.78)	CHSTSGRDvDSQVSCDKRRTVQASK
  847-  870 (42.17/23.52)	CSADSGVD.ESQGSIKRSIGSTHSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.99|      57|     610|    1319|    1477|       5
---------------------------------------------------------------------------
 1420- 1477 (87.42/194.90)	ISNDNSHSSAKATLGRTTKMAAV..SALVIG........AIIHGVISLERmVSVLRLKEGLDVVQFVR
 2023- 2089 (86.57/22.39)	VHEDVDLSSNLAQLKRDMELMPIvaSTEMSGdslfdrllLVLHGLLSSCK.PSWLKSKDAKDFSGFDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.74|      18|      55|    1217|    1235|       8
---------------------------------------------------------------------------
 1217- 1235 (33.35/23.60)	PHGvPAGTEDPDDY.CRQRI
 1275- 1293 (29.39/15.76)	PKS.PATEKGGDDYqVAQQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     201.24|      65|     900|      76|     148|      11
---------------------------------------------------------------------------
   76-  148 (97.38/95.61)	CPEETLTRENVQhgykdTIDGLEDSKE...IS....LTQVQAFTKPVVLKCRDAIRKCLraINESRAQKRKAGQvYGVPL
  977- 1048 (103.86/75.70)	CPHHRTEVENLK.....PVDGIRTTHHadiISigrgLKQLRFVEKRVVTIWLLSVVKQL..VEESEKSVPKASQ.YGRPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.01|      22|     900|     492|     521|      17
---------------------------------------------------------------------------
  492-  514 (31.91/32.33)	ATAGyPSQSVAKAVQTLDKALLQ
 2198- 2219 (38.10/16.21)	AGSG.PSSSSTAAIGGSDNANLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12972 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSVTRGVSKQTGTATSGIEGPTNKINNRKGIRGGSPGLAKRTPAPVESAPPPSPA
2) RYHAPSCTSAVNNSAIGGASVRDTPRVDSSSLPPNFSLNSR
3) SKVDPLLKSTKQASRGRQKSVRKTQSLAQLAAARI
1921
3
925
1975
43
959










Molecular Recognition Features






MoRF SequenceStartStop




1) IDPWTLLEY
2) SYIGAVD
2188
2236
2196
2242