<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12961

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMAEKQLIVAVEGTAAMGPYWHIVVSDYLDKIIRCFCSSELTGQKNSTSNVEFSLVTFNTHGSYCACLVQRSGWTKDVDIFLQWLSAIPFSGGGFNDAAIAEGLSEALMMFPIASNGNQTPQNVDGQRHCILVAASNPYPLPTPVYRPQIQNLEQVENSEAQTESRLSDAETVARSFAQCSVSLSVICPKQLAKLKAIYSAGKQNPRAADPPVDNVKNSQFLVLISENFMEGRAALSRSGLPSLATNQSPVKMDMASVTSVTGPPPSSVNGSMVGRLPVSVGNVATATVKVEPTTITSMATGPAFSHVPSVPRAPSQAIPTLQTSSPLTNTLEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNILNNLSQARVMSSAALTGGTSIGLQSMVQTPVAMHMSNMISSGMASSVPPAHTVLSSGQPTMTSLTGSGALTGAAQVLPNSGLSSFSSATSNVAGNSNIGISQPMGNVQGAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQALGVSNSSAASMPLSQQTSSALQSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASETLAAHWPQTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLGQLQEKKLCAVIQLPQQTLLLSVSDKACRLIGMLFPGLHSSNTPPGLHPSLDKPKKLNEMDMVVFKPQMSSQQQLQLQQQQMQPQLQQQQQQQNPQLQQQQLPHLQQQQLPQLQQQQQQQQLPQLQQQQLSQLQQQQQQQKQQQQQQQQSQHPQMQQQQLSQQQQMVGSGMGPAYVQGPG
Length822
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.04
Grand average of hydropathy-0.334
Instability index60.43
Isoelectric point8.75
Molecular weight87877.51
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12961
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.10|      23|      25|     726|     750|       1
---------------------------------------------------------------------------
  726-  749 (41.79/16.28)	...PQLQQQQQQ.QN.PQLQQQQLPhlQQ
  750-  772 (31.94/ 7.37)	QqlPQLQQQQQQ.QQlPQLQQQQL.....
  782-  805 (46.37/14.34)	Q..KQQQQQQQQsQH.PQMQQQQLS..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     462.79|     102|     104|     301|     404|       2
---------------------------------------------------------------------------
  166-  257 (117.10/46.49)	...LSDAETVARSFAQCSVSLSVICP...........KQ..LAKLKAIYSAGKQNPRAADPPVDNVknsQFLVLISENFMEGRAALSRS....GLPSLAtnQSP.....VKMDMASV
  301-  404 (176.60/77.16)	GPAFSHVPSVPRAPSQAIPTLQTSSPLTNTleGMTSGDN..MQELKPSVSGMTQPSRPVPPAAANV...NILNNLSQARVMSSAALTGGT.SIGLQSMV..QTP.....VAMHMSNM
  408-  480 (105.52/41.23)	GMA.SSVPPAHTVLSSGQPTM.TS..LTGS..GALTG.A..AQVL.PN.SGLSSFSSATSNVAGNS...NI..GISQP..MGN..VQGAV.NIG.......................
  481-  539 (63.57/22.15)	...............QSVP.............GMSQGNHsgTQMMQSGV.GMSQ...................N......MS..ALGQSTvSSGNGTMI..PTPgmsqqVQSGMQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.96|      16|      29|     667|     682|       4
---------------------------------------------------------------------------
  668-  694 (22.27/10.89)	KACRLIGM...LF.PGLHSsntppglhpslD
  695-  714 (18.68/ 7.94)	KPKKLNEMdmvVFkPQMSS...........Q
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12961 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQ
2) KQQQQQQQQSQHPQMQQQQLSQQQQMVGSGMGPAYVQGPG
3) LSRSGLPSLATNQSPVKMDMASVTSVTGPPPSSVNGSMVGR
4) NMISSGMASSVPPAHTVLSSGQPTMTSLTGSGAL
5) TITSMATGPAFSHVPSVPRAPSQAIPTLQTSSPLTNTLEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNI
475
783
235
403
294
537
822
275
436
366










Molecular Recognition Features






MoRF SequenceStartStop




1) MVGSGMGPAYVQGPG
2) PQMQQQQLSQQ
808
795
822
805