<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12957

Description mediator of RNA polymerase II transcription subunit 25-like
SequenceMAEKQLIVAVEGTAAMGPYWHIVVSDYLDKIIRCFCSSELTGQKNSTSNVEFSLVTFYTHGSYCACLVQRSGWTKDVDIFLQWLSAIPFSGGGFNDAAIAEGLSEALMMFPIASNGNQTPQNVDGQRHCILVAASNPYPLPTPVYRPQIQNLEQVENSEAQTESCLSDAETVARSFAQCSVSLSVICPKQLAKLKAIYSAGKRNPRAADPPVDNVKNSQFLVLISENFMEGRAALSRSGVPSLATNQSPVKMDMASVTSVTGPSPSSVNGSMVGRLPVSVGNVATATVKVEPTTITSMATGPAFSHVPSVPRVPSQAIPTLQTSSPLTNTQEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNILNNLSQARVMSSAALTGGTSIGLQSMGQTPVAMHMSNMISSGMASSVPPAHAVLSSGQPTMTSLTGSGALTGTAQVPPNSGLSTFSSASSNVAGNSNIGISQPTGNVQGAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQTLGVSNSSAASMPLSQQTSSALQSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASETLAAHWPQTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLGQLQEKKLCAVIQLPQQTLLLSVSDKACRLIGMLFPGLHSSNTPPGLHPSLDKPKKLNEMDMVVFKPQMSSQQQLQLQQQQK
Length724
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.05
Grand average of hydropathy-0.151
Instability index51.89
Isoelectric point8.71
Molecular weight76301.85
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12957
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     236.29|      50|      53|     469|     520|       1
---------------------------------------------------------------------------
  345-  410 (40.17/11.93)	P............SVSGMT....QPsrpvppaaanvnilnNLSQARVMSSAAltgGTS.........IGLQSM..GQT...PVamhmsnmiSSGMA
  414-  462 (65.52/23.64)	PP..AHAVLSSGQ..PTMTsltgSG...............ALTGTAQVPPNS...GLS.........TFSSAS....S...NV.........AGNS
  469-  520 (89.70/38.95)	PTgnVQGAVNIGQSVPGMS....QG...............NHSGTQMMQSGV...GMS.........QNMSAL..GQS...TV........SSGNG
  524-  573 (40.91/12.27)	PT.............PGMS....QQ...............VQSGMQTL..GV...SNSsaasmplsqQTSSALqsAQSkyvKV........WEGN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.45|      34|      37|     250|     285|       2
---------------------------------------------------------------------------
  235-  277 (45.59/26.92)	LSrsgVPSLATnqspVKMDMASVTSV.TGPSPSSVNGsmVGRLP
  278-  314 (52.85/25.80)	VS...VGNVAT..atVKVEPTTITSMaTGPAFSHVPS..VPRVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12957 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSRSGVPSLATNQSPVKMDMASVTSVTGPSPSSVNGSMVGR
2) LTGGTSIGLQSMGQTPVAMHMSNMISSGMASSVPPAHAVLSSGQPTMTSLTGSGALTGTAQVPPNSGLSTFSSA
3) TITSMATGPAFSHVPSVPRVPSQAIPTLQTSSPLTNTQEGMTSGDNMQELKPSVSGMTQPSRPVPPAAANVNI
4) VAGNSNIGISQPTGNVQGAVNIGQSVPGMSQGNHSGTQMMQSGVGMSQNMSALGQSTVSSGNGTMIPTPGMSQQVQSGMQTLGVSNSSAASMPLSQQT
235
381
294
458
275
454
366
555










Molecular Recognition Features






MoRF SequenceStartStop




1) MDMVV
702
706