<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12948

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X1
SequenceMDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSSQDSLNELRKIAVRFEEKIFTAATSQSDYLKRISLKMLTMENKSQNTVPNTGDNSIPPDPGSQGMQNQVHSQGQSIPLSLQSNQSQAQLLPQSVPNNMASAGVQSSAGLQSEMPAISGLTLSSVPDVVEQHE
Length181
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.03
Grand average of hydropathy-0.735
Instability index67.56
Isoelectric point5.60
Molecular weight19916.96
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12948
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.92|      16|      17|     123|     138|       1
---------------------------------------------------------------------------
  103-  120 (23.54/11.49)	NSIPpdPGSQGM..QNQVHS
  123-  138 (27.72/14.74)	QSIP..LSLQSN..QSQAQL
  141-  158 (21.66/10.02)	QSVP..NNMASAgvQSSAGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.07|      14|      19|      53|      70|       4
---------------------------------------------------------------------------
   53-   70 (16.72/22.06)	SLNE.LRKIAVrfeeKIFT
   74-   88 (18.35/11.40)	SQSDyLKRISL....KMLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12948 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTMENKSQNTVPNTGDNSIPPDPGSQGMQNQVHSQGQSIPLSLQSNQSQAQLLPQSVPNNMASAGVQSSAGLQSE
2) MDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSS
87
1
161
50










Molecular Recognition Features






MoRF SequenceStartStop




1) IVNKIM
2) YLKRISLKMLTM
34
78
39
89