<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12947

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X2
SequenceMDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSGQDGLNELRKIAVRFEEKIFTAATSQSDYLKRISLKMLTMENKSQNTVPNTGNNSKPPDPGSQGMQNQVHSQGLSIPISLQCNQSQAQLLPQSVPNNMASAGVQSSAGLQSGMPAVSGLTQNPVPNVVGQNTNIQNMSGISQNSLGQGMSSNMFANQQRQMPRQQVLPQQQQQQQQQQLYHQQLQNQLIKQKMQQGNLQPSLMQSHMQQQQNLLPPTQLQSSQQSGMQTSSVIQQSSMQSTPLPGLQHNQQSSLQQSSQSMLQQHQQFRQQQQAQQAASSGIHQQQTPMIQQSMMPPQQHQHQPPQPQHQQPHIMGQQTNAANSQQNQLIGQQNSIADMQQQRLLGQANNLPNLQQQQQQQQQLMAQKNNMSNIHQQQLGPQSNSSGLQQQQQQQPHLIGAQSGNSSMQANQQSLHMLPQPKVQLQQTQQSSPNLLPPTQVQTSQQPQQQQQQLMSQMQTQSTLQQQLGLQQQHNMQQRLQASSQVSSSLLQSQNLTEQQKQLYQSQRAVTEISSTSLDSTAQTGLANGGDWQKEVHQKILTLKEAYLPELNEMYQKIATKLQQHDSNPAQPKSEQLEKLKIFKTMLERIIGFLTVSRANITPPFKEKLSSYEKQIINFINSNRPRKPVSVLQQGQLPPPHMHSMQQQQQSQISQTQSHDNQMNPQLQSMNLQGSVPTMQPNNMTSMQHNSLSPGVSTAQQTMLNSLQPGSSLDSGQGNALGPVQQVAPGPLQQNPHQHMKQQQEQQMLQSQKCKQQFQQRQMQHQCIQQKQQLLQQQQQQQQQQRQQQQQQQAKQQLSTHQMSQLHQMNDVNDMRQGMGVKPGVFQHLSAGQRQSYTHQQLKPGAQFPVSSPQLLQAVSPQMPQHSSPQVDQQNLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPVLGTSLPNVANLGHQQGTGVQTGSQSLAIGTPGISASPLLAEFSGADGTHANALTAVSSKLNVTEQPLERLIKAVKSISPTALGASVSDIGSVVSMTDRIAGSAPGNGSRAAVGEDLVAMTKCRLQAKNFISQDGMSGTKKIRRYTSAMPLNVVSSAGSLNDSFKQLTGSETSELESTATSSVKRPRIEANHALLEEIREINQRLIDTVVDISDEDVDPGAAAATAEGGEGTIVKCSFSAVALSANLKSQYMSAQMSPIQPLHLLVPTNYPNCSPILLDKFPVEVSKENEDLSVKAKSRFSISLRTLSQPMSLGEIARTWDVCARAVISDHAKLSGGGSFSSKYGTWENCLSAA
Length1317
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.03
Grand average of hydropathy-0.788
Instability index72.76
Isoelectric point9.35
Molecular weight144924.64
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12947
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     962.25|      88|      88|     355|     442|       1
---------------------------------------------------------------------------
   99-  167 (63.86/ 9.32)	........................NTGNN...SKP..P....DPGSQG...................M..QNQ.VH..S.....QGLSIPIS.....LQC.N....QSQAQLLP......Q..SvpNNM..ASAGvQSSAG......LQ...SGMPAVSG
  168-  261 (113.50/23.73)	L.T....QNP.V..PNVVG..QNTNIQNMsgiSQN..S....L.GQGMS................SNMfaNQQRQM..P.....RQQVLPQ......QQQ.Q....QQQQQLYH......QqlQ..NQLikQKMQ.QGNLQ......PSLMQSHMQQQQN
  263-  336 (90.26/16.98)	L.P....PTQlQ..S.............S...QQS.........GMQTS................SVI..QQSSM.........QSTPLPGL.....QHN.QqsslQQSSQSML......Q..Q..H....QQFR.QQQQA......QQAASSGIHQQQT
  355-  442 (162.29/37.90)	Q.P....QHQ.Q..PHIMG..QQTNAANS...QQN..Q....LIGQQNS...............IADM..QQQRLL..G.....QANNLPNL.....QQQ.Q....QQQQQLMA......Q..K..NNM..SNIH.QQQLG......PQSNSSGLQQQQQ
  446-  524 (87.91/16.30)	...............HLIG..AQSGNSSM...QAN..QqslhMLPQPK.................VQL..QQTQ.Q..S.....SPNLLPPTqvqtsQQP.Q....QQQQQLMS......Q..M..QTQ..STL..QQQL.............GLQQQHN
  530-  605 (69.77/11.03)	Q.A....SSQ.V..SSSLL..QSQNLTE....QQK..Q....LYQSQRA...............VTEI..SSTSLD..S.....TAQ..TGL.....ANG.G....DWQK......................EVH.QKILTlkeaylPE.....LNEMYQ
  608-  698 (74.10/12.29)	A.T....KLQ.Q...H......DSNPAQP...KSE..Q....L..EKLK...............IFKT..MLERII..GfltvsRANITPPF.....KEKlS....SYEKQIINfinsnrP..R..KPV..SVLQ.QGQLP......PPHMHS.MQQQQ.
  699-  755 (66.11/ 9.97)	...........Q..SQI....SQTQ...S...HDN..Q....MNPQ.....................L..QSMNLQ..G........SVPTM.....QP...........................NNM..TSMQ.HNSLS......PGVSTAQQTMLNS
  757-  840 (103.03/20.69)	Q.PgsslDSG.Q..GNALGpvQQVAPGPL...QQNphQ....HMKQQ.......................QEQQML........QSQKCKQQ.....FQQ.R....QMQHQCIQ......Q..K..QQL....LQ.QQQ.........QQQQQQRQQQQQ
  841-  907 (70.53/11.25)	Q.Q....AKQ.QlsTHQM..........S...QLH..Q....M....ND...............VNDM..RQGMGVkpG.....VFQHLSAG.....QRQ.S....YTHQQL..........................KPG......AQFPVSSPQLLQA
  911-  990 (60.89/ 8.45)	QmP....QHS.S..PQV.D..QQNLPSIS...KTG..T....PLQSANSpfvvpspstplapspMPGE..SEKPVL..G.....TS..LPNV.................A.................NL..G..H.QQGTG......VQTGSQSL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      20|      21|    1041|    1060|       2
---------------------------------------------------------------------------
 1041- 1060 (34.06/27.80)	ISPTALG.ASVSDIG.SVVSMT
 1063- 1084 (25.94/18.94)	IAGSAPGnGSRAAVGeDLVAMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.14|      12|      15|       1|      12|       5
---------------------------------------------------------------------------
    1-   12 (26.56/15.95)	MDTNNWRS..TPPS
   17-   30 (21.58/11.48)	MDTGDWRTqlQPDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12947 with Med15 domain of Kingdom Viridiplantae
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