<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12943

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X1
SequenceMDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSGQDGLNELRKIAVRFEEKIFTAATSQSDYLKRISLKMLTMENKSQNTVPNTGNNSKPPDPGSQGMQNQVHSQGLSIPISLQCNQSQAQLLPQSVPNNMASAGVQSSAGLQSGMPAVSGLTQNPVPNVVGQNTNIQNMSGISQNSLGQGMSSNMFANQQRQMPRQQVLPQQQQQQQQQQLYHQQLQNQLIKQKMQQGNLQPSLMQSHMQQQQNLLPPTQLQSSQQSGMQTSSVIQQSSMQSTPLPGLQHNQQSSLQQSSQSMLQQHQQFRQQQQAQQAASSGIHQQQTPMIQQSMMPPQQHQHQPPQPQHQQPHIMGQQTNAANSQQNQLIGQQNSIADMQQQRLLGQANNLPNLQQQQQQQQQLMAQKNNMSNIHQQQLGPQSNSSGLQQQQQQQPHLIGAQSGNSSMQANQQSLHMLPQPKVQLQQTQQSSPNLLPPTQVQTSQQPQQQQQQLMSQMQTQSTLQQQLGLQQQHNMQQRLQASSQVSSSLLQSQNLTEQQKQLYQSQRAVTEISSTSLDSTAQTGLANGGDWQKEVHQKILTLKEAYLPELNEMYQKIATKLQQHDSNPAQPKSEQLEKLKIFKTMLERIIGFLTVSRANITPPFKEKLSSYEKQIINFINSNRPRKPVSVLQQGQLPPPHMHSMQQQQQSQISQTQSHDNQMNPQLQSMNLQGSVPTMQPNNMTSMQHNSLSPGVSTAQQTMLNSLQPGSSLDSGQGNALGPVQQVAPGPLQQNPVSTSQQTNFNSNSLSSQSGLSVLPQNINPLQSNSNMLQHQHMKQQQEQQMLQSQKCKQQFQQRQMQHQCIQQKQQLLQQQQQQQQQQRQQQQQQQAKQQLSTHQMSQLHQMNDVNDMRQGMGVKPGVFQHLSAGQRQSYTHQQLKPGAQFPVSSPQLLQAVSPQMPQHSSPQVDQQNLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPVLGTSLPNVANLGHQQGTGVQTGSQSLAIGTPGISASPLLAEFSGADGTHANALTAVSSKLNVTEQPLERLIKAVKSISPTALGASVSDIGSVVSMTDRIAGSAPGNGSRAAVGEDLVAMTKCRLQAKNFISQDGMSGTKKIRRYTSAMPLNVVSSAGSLNDSFKQLTGSETSELESTATSSVKRPRIEANHALLEEIREINQRLIDTVVDISDEDVDPGAAAATAEGGEGTIVKCSFSAVALSANLKSQYMSAQMSPIQPLHLLVPTNYPNCSPILLDKFPVEVSKENEDLSVKAKSRFSISLRTLSQPMSLGEIARTWDVCARAVISDHAKLSGGGSFSSKYGTWENCLSAA
Length1355
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.03
Grand average of hydropathy-0.782
Instability index73.21
Isoelectric point9.35
Molecular weight148971.97
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12943
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|    1002.79|      88|      88|     355|     442|       1
---------------------------------------------------------------------------
   10-   95 (56.02/ 7.16)	.PPSG.E..P..T..MdTGDWRTQLQP...DSRQ....RI..VNK...............IMDT..LKRHLpfS..G.....Q.DGL.NEL.....RKiavrfE.E....K.......IFTAA.T..S......Q..S..DYL..KRIS.LKMLT......M.ENKS......QN
  100-  167 (68.80/10.99)	TGNNS.K..P..P..D.PGSQ.....G...MQNQ....VHSQGLS...............I...........................PIS.....LQ.....C.N....Q.......SQAQL.L..P......Q..SvpNNM..ASAGvQSSAG......L.Q...SGMPAVSG
  168-  261 (108.43/22.88)	LTQNP.V..P..N..V.VGQNTNIQNMsgiSQNS....L.GQGMS................SNMfaNQQRQ..M..P.....RQQVL.PQ......QQ.....Q.Q....Q.......QQQQL.Y..H......QqlQ..NQLikQKMQ.QGNLQ......P.SLMQSHMQQQQN
  263-  336 (87.82/16.70)	LPPTQlQ..S................S...QQS.......GMQTS................SVI..QQSSM...........QSTPL.PGL.....QH.....N.QqsslQ.......QSSQS.M..L......Q..Q..H....QQFR.QQQQA......Q.QAASSGIHQQQT
  355-  442 (159.59/38.23)	QPQHQ.Q..P..H..I.MGQQTNAANS...QQNQ....LIGQQNS...............IADM..QQQRL..L..G.....QANNL.PNL.....QQ.....Q.Q....Q.......QQQQL.M..A......Q..K..NNM..SNIH.QQQLG......P.QSNSSGLQQQQQ
  446-  524 (83.47/15.40)	............H..L.IGAQSGNSSM...QANQqslhMLPQPK.................VQL..QQTQ...Q..S.....SPNLL.PPTqvqtsQQ.....P.Q....Q.......QQQQL.M..S......Q..M..QTQ..STL..QQQL..............GLQQQHN
  530-  605 (67.29/10.54)	QASSQ.V..S..S..S.LLQSQNLTE....QQKQ....LYQSQRA...............VTEI..SSTSL..D..S.....TAQ...TGL.....AN.....G.G....D.......WQK.........................EVH.QKILTlkeaylP.E.....LNEMYQ
  608-  699 (78.63/13.94)	ATKLQ.Q.....H.......DSNPAQP...KSEQ....L..EKLK...............IFKT..MLERI..I..GfltvsRANIT.PPF.....KE.....KlS....S.......YEKQI.I..NfinsnrP..R..KPV..SVLQ.QGQLP......P.PHMHS.MQQQQQ
  701-  793 (73.37/12.36)	QISQT.Q..S..HdnQ.MNPQLQSMN...............LQGS...............VPTM..QPNNM..T..S....mQHNSLsPGV.....ST.....A.Q....QtmlnslqPGSSLdS..G......Q..G..NAL..GPVQ.QVAPG......PlQQNPVSTSQQTN
  797-  878 (107.33/22.55)	NSLSS.Q..SglS..V.LPQNINPLQS...NSNM....L..QHQH...............MKQQ..QEQQM..L........QSQKC.KQQ.....FQ.....Q.R....Q.......MQHQC.I..Q......Q..K..QQL....LQ.QQQ..........QQQQQQRQQQQQ
  879-  949 (54.24/ 6.63)	QQAKQ.QlsT..H..Q.M........S...QLHQ....M....ND...............VNDM..RQGMG..VkpG.....VFQHL.SAG.....QR.....Q.S....Y.......THQQL.KpgA......Q..F..PVS..SPQL.LQAVS......P.Q...........
  951- 1028 (57.78/ 7.69)	.PQHS.S..P..Q..V..DQQNLPSIS...KTGT....PLQSANSpfvvpspstplapspMPGE..SEKPV..L..G.....TS..L.PNV.............................A....................NL..G..H.QQGTG......V.QTGSQSL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      20|      21|    1079|    1098|       2
---------------------------------------------------------------------------
 1079- 1098 (34.06/19.32)	ISPTALG.ASVSDIG.SVVSMT
 1101- 1122 (25.94/13.10)	IAGSAPGnGSRAAVGeDLVAMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.11|      17|      26|    1308|    1324|       6
---------------------------------------------------------------------------
 1308- 1324 (32.62/20.93)	LSQPMSLGEIARTWDVC
 1335- 1351 (33.49/21.69)	LSGGGSFSSKYGTWENC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12943 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IKQKMQQGNLQPSLMQSHMQQQQNLLPPTQLQSSQQSGMQTSSVIQQSSMQSTPLPGLQHNQQSSLQQSSQSMLQQHQQFRQQQQAQQAASSGIHQQQTPMIQQSMMPPQQHQHQPPQPQHQQPHIMGQQTNAANSQQNQLIGQQNSIADMQQQRLLGQANNLPNLQQQQQQQQQLMAQKNNMSNIHQQQLGPQSNSSGLQQQQQQQPHLIGAQSGNSSMQANQQSLHMLPQPKVQLQQTQQSSPNLLPPTQVQTSQQPQQQQQQLMSQMQTQSTLQQQLGLQQQHNMQQRLQASSQVSSSLLQ
2) KPVSVLQQGQLPPPHMHSMQQQQQSQISQTQSHDNQMNPQLQSMNLQGSVPTMQPNNMTSMQHNSLSPGVSTAQQTMLNSLQPGSSLDSGQGNALGPVQQVAPGPLQQNPVSTSQQTNFNSNSLSSQSGLSVLPQNINPLQSNSNMLQHQHMKQQQEQQMLQSQKCK
3) LTMENKSQNTVPNTGNNSKPPDPGSQGMQNQVHSQGLSIP
4) MDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSGQD
5) QQKQQLLQQQQQQQQQQRQQQQQQQAKQQLSTHQMSQLHQMNDVNDMRQGMGVKPGVFQHLSAGQRQSYTHQQLKPGAQFPVSSPQLLQAVSPQMPQHSSPQVDQQNLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPVLGTSLPNVANLGHQQGTGVQTGSQSLA
6) SQAQLLPQSVPNNMASAGVQSSAGLQSGMPAVSGLTQNPVPNVVGQNTNIQNMSGISQNSLGQGMSSNMFANQQRQMPRQQVLPQQQQQQQQQQLYHQQLQN
238
676
87
1
856
134
541
842
126
52
1029
235










Molecular Recognition Features






MoRF SequenceStartStop




1) IINFI
2) KKIRRY
665
1141
669
1146