<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12935

Description U-box domain-containing protein 35-like isoform X2
SequenceMEKKEREEAENELVLPPSPTLTIGIAINGNRESKYVVKWALEKFVPEGNVMFKLLHVRAKIKLVPTPMGNLLPISQVREDVAAAYKKELEWQANEMLLPYKMCAQRKVEADIIIIESDQVANAIAEEVSKNTITRLVIGASSRGMLTRKLKKNNLSSRISACAPSFCTVYAISKGKLTSIRPSDSEMNGSTKDDSSETSFSSKNSSDYSFSSLTGSVATYATFRSPSLPMQRSQTLSMINQTHLHSRTSSLASNQFRSTESTQFKSPDNNHSRCQSLDNAAGNDDMSSCPNSSESREAVSRNSSRRSLQTYQQSWLPDQISTLDAQADNNPSECEVNINFELEKLRTELRHIREMHAAAQSETIDASQKLNTLSKRRLEEAMKLKEVCLKEEEAKELARQEKAKCEAAIREAVHVKGCADREASLRREAAMKASHEAKEKEKLENYLTGPLQQYQKFTWDEIVSATSSFSEDLRIGMGAYGTVYKCIFHHTAAAVKVLHSKENGRTKQFQQELEILSKIRHPHLLLLLGACPEHGCLVYEYMENGSLEDRLLRKNNTPPIPWFERYRIAWEVGSALVFLHNSKPEPIIHRDLKPANILLDHNFMSKIGDVGLSVMITTDSSSTSTVYKDTGPVGTLCYIDPEHQRTGLISPKSDIYAFGMIILQLLIAKPAIALTHVVETAIDNDNLTRILDSEAGNWPVEETKELAILGLSCAELRRKDRPGLKDRVLPILEKMKEVANKARNSISNIQSAHPNHFICPISKDVMDEPCVAADGYTYERKAIEKWIETNDISPMTNLALPNKNLLPNYSLLSAILEWKSRKQ
Length823
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.06
Grand average of hydropathy-0.475
Instability index48.10
Isoelectric point7.28
Molecular weight92315.07
Publications
PubMed=25893780

Function

Annotated function Functions as an E3 ubiquitin ligase. 
ECO:0000256	ARBA:ARBA00003861
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12935
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.07|      14|      80|       3|      16|       1
---------------------------------------------------------------------------
    3-   16 (24.26/15.84)	KKEREEAENELVLP
   86-   99 (26.81/18.29)	KKELEWQANEMLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.13|      31|     142|     355|     388|       2
---------------------------------------------------------------------------
  323-  354 (46.78/27.29)	LDAQADNNPSECEVNINfELEKLR.TELRHIRE
  355-  386 (44.35/38.13)	MHAAAQSETIDASQKLN.TLSKRRlEEAMKLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      25|      42|     155|     183|       3
---------------------------------------------------------------------------
  155-  181 (33.64/23.00)	LSSRISAcAPSFCTVYAiSKGKLTSIR
  200-  224 (41.73/18.91)	FSSKNSS.DYSFSSLTG.SVATYATFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.75|      13|     412|     268|     283|       8
---------------------------------------------------------------------------
  242-  254 (22.55/11.73)	THLHSRTSSL...ASN
  268-  283 (20.20/18.07)	DNNHSRCQSLdnaAGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12935 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SRTSSLASNQFRSTESTQFKSPDNNHSRCQSLDNAAGNDDMSSCPNSSESREAVSRNSSRRSLQTY
246
311










Molecular Recognition Features






MoRF SequenceStartStop




NANANA