<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12928

Description mediator of RNA polymerase II transcription subunit 12-like
SequenceMQRYHAPSCTSAVNNSAIGGASVRDTPQADSSSLPPNFSLNSRRQSQLAPYKLKCDKEHLNSRLGPPDFHPQTQNCPEETLTRENVQHGYKDTIDGLEDSKEISLTQVQAFTKPVVLKCRDAIRKCLRAINESRAQKRKAGQVYGVPLSGSLLSKPGVFPEQRPCNEDFRKKWIEGLSLQHKPLCSLADQVPLGYKKRPLIEVLIRNNVPLLKATWFIKVTYLNQVRPGSAISSGAPDKTQLSRTELWTKDVIDYLQYLLDEFFSRNNSHSTQHGRDRLPQIHYAGSLQHRSDLAPAVIDGEEPSLHFKWWYVVRLLQWHHAEGLVLPSLIIDWVLNQLQEKDLLEILQLLLPIIYGVLETIILCQTYVRNLVGVAIRFIREPSPGGSDLVDNSRRAYTISALVEMLRYLIQATPDTFVALDCFPLPTCVLSLTPSDGGFLSKPSDDAAKKKYTADAYAVRGKGFDSQYQSLSFNHVVSTVEKRADNLAKGATAGYPSQSVAKAVQTLDKALLQGDVIDAYKHIFNDLYDGAVGEGWVAEVSPCLRSSLKWLQTVNLSLICSVFFLCEWATCDYRDFRTAPPSDVKFTGSKDFSQIYLAIQLLKLKMKELQKKLKKGRTSRKNTSQQNSYSSKDLLGDTHEAKSNGKGLNGRRRNFSDIFDSPGPLHDIIVCWIDQHEGHKGEGSKRLQLFMLELIRSGIFYPQAYVRQLLVSGIIDTNGPMADLNRSKRHQRILKQLPGQFMLNALEEARIAEGSELLEAINVYSNERLLVLQELFFDSYNNTNNSHALAKKLNCRPTLGRDVDSQVSCDKRRTVQASKTFRREVGLEELKASISVLLQFPSSSFCSADSGEDESQGSIKRSIGSTHSKMDSVEGTPGCEDCKRVKRLKLSEDETSCLKVYSPIPSDDDDTWWVRKGPKNLEGSKVDPLLKSTKQASRGRQKPVRKTQSLAQLAAARIEDSQGASTSHVCDNKISCPHHRTEVENLKPVDGIRTAHHADIISIGRGLKQLRFVEKRVVTIWLLSVVRQLVEESEKSVPKASQYGRPFVAADEKSPLRWKLGEDELSAILYLLDVSCDSASAVKFLLWLLPKAISNPSPSIHSGRNILMVPRNVENYACEVGEAYLLSSLRRYENILIAADLVPEALSATMRHVASFMATNGRITGSGALVFACYLLRRYGSIASVIEWEKNFKETCDKRLLSELESGRTEGEFGFPHGVPAGTEDPDDYCRQRINVGRLSRAGVSMRDMVQRRIDDVLHYILGKERKHFAANTPRSPATEKGDDDYQVAQQIIMGLMDCFRQTGGAFQEGDPGLVSSAVSAIVSNVGPTIAKIPDFTSGSTYSNYQPPMNYLNFAKRLLHIHLICLCLLKEALGERKSQAFEIALATEAFSALAVAFAPAKSSRGQLLSPDSLDSHANMSNDNSHSSAKATLGRTAKMAAAVSALVIGAIIHGVISLERMVSVLRLKEGLDVVQFVRSTKTSSNGNARSVGAFKVDNSVEVYVHLFRLFVGNCRTVCDGLVLELLGEQSVLALSRMQRLLPINLVFPPAYAIFAFMIWKPFILNSNTARSEDIHQLYQSLTVAIGDAIKHRPFRDVCMRDTRGFYDIVAADTTDAEFAAMLELNGLDMHLKSMVFVPLRARLFLNAIIDCKMPNSAFTQDDGNRVSGHSESKALRAETSKLLDKLVCALDTLQPAKFHWQWVELRLLLNEQALIDKIENHDMSIVDAIRSSSPSSERATPSESEKVFIEIILTRLLVRPDAAPLFSEVVHLFGRSLEDSMLMQAKWFLGGLDVLLGRKTVRQRLSNIAENKNLSTKSQFWKPWGWSYSGVDPVTNSGEKRKSEVTSLEEGEVIEEGMESKGCVKGSTQVDIEGSGINQQHVTEKAFIELVIPCIDQSSADSHNTFASDLIKQFNTIEQQINSVTRGVSKQTGTATSGIEGPTNKINNRKGIRGGSPGLAKRTPAPVESAPPPSPAALRASMSLRLQFIVRLLPIICADGEPSARSMRNMLASVILRLLGSRVVHEDVDLSSNLAQLKRDMELMPVVASTEMSGDSLFDRLLLVLHGLLSSCKPSWLKSKDAKDFSGFDREAVEGLQNELDSMQLPEMIRWRIQAAMPILFPSFHNTVSCQPPSVPIGALSLLQPSICVPGSYTGTINPSQRQVASARNANNMPGKSKSVLSQENDMEIDPWTLLEYGAGSGPSSSSTAAIGGSDNANLRASSWLKGAVRVRRTDPSYIGAVDDDS
Length2246
PositionKinase
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.07
Grand average of hydropathy-0.267
Instability index47.86
Isoelectric point8.52
Molecular weight248621.94
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12928
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.57|      58|     602|     617|     731|       1
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  672-  731 (97.99/125.11)	CWiDQHEGHKGEGSKRLQLFMLELIRSGIFYPQAYVRQlLVSGIIDTN..GPMADLNRSKR..H
 1300- 1361 (95.59/35.55)	CF.RQTGGAFQEGDPGLVSSAVSAIVSNVGPTIAKIPD.FTSGSTYSNyqPPMNYLNFAKRllH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.55|      77|     607|     734|     861|       2
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  778-  861 (117.24/146.77)	FDSYNN..TNNSHALAKklncrPTLGRDVDSQVSCDK...RRTVQASKTFRREVGLEELKASISVlLQFPSSSFCSADsGEDESQGSIK
 1414- 1495 (116.32/57.90)	LDSHANmsNDNSHSSAK.....ATLGRTAKMAAAVSAlviGAIIHGVISLERMVSVLRLKEGLDV.VQFVRSTKTSSN.GNARSVGAFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     379.16|     126|     602|    1072|    1250|       3
---------------------------------------------------------------------------
  481-  625 (184.99/84.66)	VEKRADNLAKGATAGYPSQSVAKAVQTLDKALLQGDVIDA.YKHIFNDL.YDGAV.GEGwvAEVSPC..LR......SSLKWLQtvNLSLICSVFFLCEWATcDYRDFRTAPPSDVKfTGSKDFSQiYLaiqllklkmkelQKKLKKGRTSRKNTS
 1110- 1246 (194.17/120.50)	VPRNVENYACEVGEAYLLSSLRRYENILIAADLVPEALSAtMRHVASFMaTNGRItGSG..ALVFACylLRrygsiaSVIEWEK..NFKETCDKRLLSELES.GRTEGEFGFPHGVP.AGTEDPDD.YC............RQRINVGRLSRAGVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     316.88|     107|     900|      24|     148|       5
---------------------------------------------------------------------------
   24-  148 (155.09/145.52)	RDTPQADSSSLPPNFSLNSrrQSQLAPYKLKcDKEhlnsrlGPPDFH..PQTQNCPEETLTRENVQhgykdTIDGLEDSKE...IS....LTQVQAFTKPVV.LKCRDAIRKclrAINESRAQKRKAGQvYGVPL
  932- 1048 (161.79/103.20)	KSTKQASRGRQKPVRKTQS..LAQLAAARIE.DSQ......GASTSHvcDNKISCPHHRTEVENLK.....PVDGIRTAHHadiISigrgLKQLRFVEKRVVtIWLLSVVRQ...LVEESEKSVPKASQ.YGRPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.65|      12|      14|     271|     282|       6
---------------------------------------------------------------------------
  271-  282 (22.64/14.92)	STQHGRDRLPQI
  287-  298 (21.01/13.21)	SLQHRSDLAPAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.84|      33|    1150|     323|     356|      12
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  323-  356 (52.18/34.93)	EGLVLPSLIIDWVLNQLQEKDLLEIlQLLLPIIY
 1519- 1551 (56.66/33.88)	DGLVLELLGEQSVLALSRMQRLLPI.NLVFPPAY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12928 with Med12 domain of Kingdom Viridiplantae
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