<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12921

Description mediator of RNA polymerase II transcription subunit 23-like
SequenceMDQTQRSVAAAANSRTYQFHPARAAITDLFNLYLGRNSRQKADDSVREPPNKTHKTQKRVLALNRELPPRNEQFLLDFEQLQTQFGDQDQLQSVTESVLISLVIQCCSHAPRAEFLLFALRSLCSIGYVNWDTFLPSLLSSVASAEGPVSQGSQGVPSVSSSVSQSGMMPSTSVIANASNFQSANAASTLTSVHVIGSPAQSTIEPSSGATLSPVKLSDIACNGQPSTTRMDSSIRDNAISNLRQLCCKMILTGLECNLKPVTQAEIFHHMLNWLVNWDQRQHGNEECDGKSWRLEKALIEWLHCCLDVIWLLVEEDKCRVPFYELLRSGLQFIENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTHRILSQTTPNVSVEGVANLRYSPITYPSVLGEPLHGEDLAASIQRGSLDWERALRCIRHAIRSTPSPDWWKRVLVVAPFYRGSVPTPGAVFTCDMICEATIDRIVELLKLTNSEINCWQEWLVFSDIFFFLMKSGCIDFVDFIDKLGSRLSASDHHILNTNHVTWLLAQIIRVEHVMTALNTDSRKVETTRKILSFHREDRSSDPNNPQSILLDFISSCQNLRIWSLNTSTREYLNNEQLQKGKQIDEWWRQVSKGTYHLLFYSLYKSIGMFWVVSYTMAQPACETVMNWLSSGGVTELLPGATELLPEANVQPNERFMVMREVSPLPISLLSGFSMNLYLKLVFQMEESLFAGQVVPSIAMVETYTRLLLIAPHSLFCSHFSHLAQRNASLLSKPAVTLLVLEIVNYRLLPLYRYQGKCKPLMYDVTKIISALKGKRGDHRVFRLAENLCINLILSLRDFFSVKREGKGPTEFTETLNRITIITLAITIKTRGIADADHLLYLQTMLEQILATSQHRWSEKTLCYFPSILRDLLMTRTDKRGLAIQEWQQSETTVINQCTQLLSSSTEPNYVMTYLNRSFPQHRQYLCAGAWILMQGHPENINSGNLARVLREFSPEEVTSNIYTMVDVLLHHIHIELQHGHSLQDLLLKTCANLAFFVWTHELIPLDILLLALIDRDDDPHALRIVISLLDRQELQQRVKLYCMNRGPPEHWLYTGIFKRSDLQNALGNHLSWKERYPTFFDDIVARLLPVIPLVVYRLIENDAIESADRMLGMYSLFLAYHPLRFTFVRDILAYFYGHLPGKLTVRILNVLDLSKIPFSESFPQHISSSNPAICPPPEYFATLLLALVNNVIPPLNSNSRTGSMGDASNNSVRGPHNKTPATPQSGPASASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPISASQIVSSLVQIVVNIQPTLIQSSNGLHGASSGAVQGSVLPTSPSGGSTDSAGRSTPSVSGINTSSFVSRSGYTCQQLSCLFIQACGLLLAQLPPEFHLQLYMEASRIIKESWWLTDGKRSLSELDSAVSYALLDPTWASQDNTSTAIGNIVALLHSFFSNLPQEWLEGTHVIIQQLRPVTSVAMLRIAFRIMGPLLPRLVTAHNLFNKILSLLLNTLVDVFGKNTQPPVPVEASEITDLIDYLHHIIHYEGQAGPVQANSKPRPEVLSICGRAAESLWPDVQHLLSHLKPDVNSSIYAATHPKIAQNPS
Length1611
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy-0.055
Instability index49.07
Isoelectric point6.42
Molecular weight180881.58
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.92|      17|      17|     424|     440|       1
---------------------------------------------------------------------------
  424-  440 (32.23/24.14)	DWERALRCIRHAIR.STP
  443-  460 (28.69/20.52)	DWWKRVLVVAPFYRgSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.47|      22|     179|     288|     337|       2
---------------------------------------------------------------------------
  311-  337 (31.98/69.35)	WLlVEEDkcrvPFYELLRSG.LQFIENI
  496-  518 (38.48/11.56)	WL.VFSD....IFFFLMKSGcIDFVDFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.84|      14|      15|     967|     980|       3
---------------------------------------------------------------------------
  967-  980 (27.34/16.64)	AWILMQGHPENINS
  984-  997 (23.50/13.27)	ARVLREFSPEEVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.10|      12|      15|    1155|    1169|       4
---------------------------------------------------------------------------
 1155- 1167 (18.75/17.61)	FLAYHPLRFTfVR
 1173- 1184 (23.35/ 8.47)	FYGHLPGKLT.VR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|      12|      17|    1043|    1055|       6
---------------------------------------------------------------------------
 1043- 1055 (15.25/16.82)	LDIlLLALIDRDD
 1060- 1071 (19.51/14.74)	LRI.VISLLDRQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      17|      17|    1198|    1214|       7
---------------------------------------------------------------------------
 1198- 1214 (32.46/19.36)	ESFPQHISSSNPAICPP
 1216- 1232 (28.21/15.78)	EYFATLLLALVNNVIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.52|      13|      18|    1234|    1246|       8
---------------------------------------------------------------------------
 1234- 1246 (23.24/14.82)	NSNSRTGSMGDAS
 1255- 1267 (24.28/15.85)	NKTPATPQSGPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.65|      16|      18|    1281|    1296|       9
---------------------------------------------------------------------------
 1281- 1296 (26.77/17.88)	PGTYTQLV..LETAVIEI
 1300- 1317 (20.87/12.23)	PISASQIVssLVQIVVNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.37|      17|     341|     591|     611|      10
---------------------------------------------------------------------------
  591-  611 (25.97/23.45)	ISSCQNLriwsLNTSTR.....EYLN
  932-  953 (25.40/11.96)	INQCTQL....LSSSTEpnyvmTYLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.43|      12|      17|    1327|    1342|      16
---------------------------------------------------------------------------
 1327- 1342 (12.02/17.92)	GlhGASSGAvqGSVLP
 1347- 1358 (22.41/12.18)	G..GSTDSA..GRSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.82|      12|      20|    1084|    1095|      27
---------------------------------------------------------------------------
 1084- 1095 (25.93/15.77)	GPPEHW..LYTGIF
 1105- 1118 (20.89/11.06)	GNHLSWkeRYPTFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.80|      32|     191|      75|     107|      29
---------------------------------------------------------------------------
   75-  107 (50.22/36.72)	LLDFEQLQTQFGDQDQLQSVTESVLISLvIQCC
  275-  306 (62.58/41.83)	LVNWDQRQHGNEECDGKSWRLEKALIEW.LHCC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12921 with Med23 domain of Kingdom Viridiplantae
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