<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12921

Description mediator of RNA polymerase II transcription subunit 23-like
SequenceMDQTQRSVAAAANSRTYQFHPARAAITDLFNLYLGRNSRQKADDSVREPPNKTHKTQKRVLALNRELPPRNEQFLLDFEQLQTQFGDQDQLQSVTESVLISLVIQCCSHAPRAEFLLFALRSLCSIGYVNWDTFLPSLLSSVASAEGPVSQGSQGVPSVSSSVSQSGMMPSTSVIANASNFQSANAASTLTSVHVIGSPAQSTIEPSSGATLSPVKLSDIACNGQPSTTRMDSSIRDNAISNLRQLCCKMILTGLECNLKPVTQAEIFHHMLNWLVNWDQRQHGNEECDGKSWRLEKALIEWLHCCLDVIWLLVEEDKCRVPFYELLRSGLQFIENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTHRILSQTTPNVSVEGVANLRYSPITYPSVLGEPLHGEDLAASIQRGSLDWERALRCIRHAIRSTPSPDWWKRVLVVAPFYRGSVPTPGAVFTCDMICEATIDRIVELLKLTNSEINCWQEWLVFSDIFFFLMKSGCIDFVDFIDKLGSRLSASDHHILNTNHVTWLLAQIIRVEHVMTALNTDSRKVETTRKILSFHREDRSSDPNNPQSILLDFISSCQNLRIWSLNTSTREYLNNEQLQKGKQIDEWWRQVSKGTYHLLFYSLYKSIGMFWVVSYTMAQPACETVMNWLSSGGVTELLPGATELLPEANVQPNERFMVMREVSPLPISLLSGFSMNLYLKLVFQMEESLFAGQVVPSIAMVETYTRLLLIAPHSLFCSHFSHLAQRNASLLSKPAVTLLVLEIVNYRLLPLYRYQGKCKPLMYDVTKIISALKGKRGDHRVFRLAENLCINLILSLRDFFSVKREGKGPTEFTETLNRITIITLAITIKTRGIADADHLLYLQTMLEQILATSQHRWSEKTLCYFPSILRDLLMTRTDKRGLAIQEWQQSETTVINQCTQLLSSSTEPNYVMTYLNRSFPQHRQYLCAGAWILMQGHPENINSGNLARVLREFSPEEVTSNIYTMVDVLLHHIHIELQHGHSLQDLLLKTCANLAFFVWTHELIPLDILLLALIDRDDDPHALRIVISLLDRQELQQRVKLYCMNRGPPEHWLYTGIFKRSDLQNALGNHLSWKERYPTFFDDIVARLLPVIPLVVYRLIENDAIESADRMLGMYSLFLAYHPLRFTFVRDILAYFYGHLPGKLTVRILNVLDLSKIPFSESFPQHISSSNPAICPPPEYFATLLLALVNNVIPPLNSNSRTGSMGDASNNSVRGPHNKTPATPQSGPASASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPISASQIVSSLVQIVVNIQPTLIQSSNGLHGASSGAVQGSVLPTSPSGGSTDSAGRSTPSVSGINTSSFVSRSGYTCQQLSCLFIQACGLLLAQLPPEFHLQLYMEASRIIKESWWLTDGKRSLSELDSAVSYALLDPTWASQDNTSTAIGNIVALLHSFFSNLPQEWLEGTHVIIQQLRPVTSVAMLRIAFRIMGPLLPRLVTAHNLFNKILSLLLNTLVDVFGKNTQPPVPVEASEITDLIDYLHHIIHYEGQAGPVQANSKPRPEVLSICGRAAESLWPDVQHLLSHLKPDVNSSIYAATHPKIAQNPS
Length1611
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy-0.055
Instability index49.07
Isoelectric point6.42
Molecular weight180881.58
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP12921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.92|      17|      17|     424|     440|       1
---------------------------------------------------------------------------
  424-  440 (32.23/24.14)	DWERALRCIRHAIR.STP
  443-  460 (28.69/20.52)	DWWKRVLVVAPFYRgSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.47|      22|     179|     288|     337|       2
---------------------------------------------------------------------------
  311-  337 (31.98/69.35)	WLlVEEDkcrvPFYELLRSG.LQFIENI
  496-  518 (38.48/11.56)	WL.VFSD....IFFFLMKSGcIDFVDFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.84|      14|      15|     967|     980|       3
---------------------------------------------------------------------------
  967-  980 (27.34/16.64)	AWILMQGHPENINS
  984-  997 (23.50/13.27)	ARVLREFSPEEVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.10|      12|      15|    1155|    1169|       4
---------------------------------------------------------------------------
 1155- 1167 (18.75/17.61)	FLAYHPLRFTfVR
 1173- 1184 (23.35/ 8.47)	FYGHLPGKLT.VR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|      12|      17|    1043|    1055|       6
---------------------------------------------------------------------------
 1043- 1055 (15.25/16.82)	LDIlLLALIDRDD
 1060- 1071 (19.51/14.74)	LRI.VISLLDRQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      17|      17|    1198|    1214|       7
---------------------------------------------------------------------------
 1198- 1214 (32.46/19.36)	ESFPQHISSSNPAICPP
 1216- 1232 (28.21/15.78)	EYFATLLLALVNNVIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.52|      13|      18|    1234|    1246|       8
---------------------------------------------------------------------------
 1234- 1246 (23.24/14.82)	NSNSRTGSMGDAS
 1255- 1267 (24.28/15.85)	NKTPATPQSGPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.65|      16|      18|    1281|    1296|       9
---------------------------------------------------------------------------
 1281- 1296 (26.77/17.88)	PGTYTQLV..LETAVIEI
 1300- 1317 (20.87/12.23)	PISASQIVssLVQIVVNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.37|      17|     341|     591|     611|      10
---------------------------------------------------------------------------
  591-  611 (25.97/23.45)	ISSCQNLriwsLNTSTR.....EYLN
  932-  953 (25.40/11.96)	INQCTQL....LSSSTEpnyvmTYLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.43|      12|      17|    1327|    1342|      16
---------------------------------------------------------------------------
 1327- 1342 (12.02/17.92)	GlhGASSGAvqGSVLP
 1347- 1358 (22.41/12.18)	G..GSTDSA..GRSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.82|      12|      20|    1084|    1095|      27
---------------------------------------------------------------------------
 1084- 1095 (25.93/15.77)	GPPEHW..LYTGIF
 1105- 1118 (20.89/11.06)	GNHLSWkeRYPTFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.80|      32|     191|      75|     107|      29
---------------------------------------------------------------------------
   75-  107 (50.22/36.72)	LLDFEQLQTQFGDQDQLQSVTESVLISLvIQCC
  275-  306 (62.58/41.83)	LVNWDQRQHGNEECDGKSWRLEKALIEW.LHCC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12921 with Med23 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSRTGSMGDASNNSVRGPHNKTPATPQSGPASASEGQKAF
1236
1275










Molecular Recognition Features






MoRF SequenceStartStop




1) LFNLYLGR
29
36