<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12912

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X2
SequenceMDYRDCEKETCRETTDHDQETLMNGNNLKPTSASEKPAMGRGDWRTQLRSDLRERIIVNKMFDTLKRHLRSSGEDKLNELRKTVEAFEEKTYNAASNQFDYVRRISLKLLQKETQSQNIVQNSGQCSNNLHNPGSQSMQSEQVHGEGLSHQNIPNDMKGKVNIYDLPGKDGPDVIFPKQWPPLPALYISEQTPTIRSTSVDCADLTMAQQNNHSNMHQQQQQQQQLMAQQNNLSNMHQQQLGPQSNISGLQQQQQQLVGTQSGNSSMQTNQQSLHMLSQPKVALQQTQQTAPNLLPTQGQTSQQPQQQQQLMSQMQSQPTQLRQQLGLQQQPNQVQQNMQQRLQASGQTSSSLLQSQNLIDQQQQLYQSQRAVPETSSTSLDSTAQTGHSNGGDWQEEVYQKIKAMKETYFPELNMMHEKISATLLQVEHDSLPQQTKSARLEKMKLFKTMLERILSFLTISRAAIVPAFKDKLSSYEDQIGKFIIANRPRKLVSALQQGQLLPTHMHSMQQPQPESNQTQSHDNQMNPLFPSMMRPAQMPQLKKQMPRLQQLQLLQMLQQRGMHRVDELQSPAKIKTNELSYLHQIDIDSGVLQENLPSNQLPGYEQASSEYHAPDTAGIGVPPIMSIPPLLPGFKEVNDTSGNALTTDFGKPDIAEQPHDLKAKPKSLSATVVTMVDEAVTSVGEDLAAMRKQGLHARNFFTQTGMSGAEKMRCYLSALVILALIIFFIFNLNHQY
Length738
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.05
Grand average of hydropathy-0.783
Instability index59.89
Isoelectric point6.88
Molecular weight83390.07
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12912
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     174.27|      28|      29|     213|     240|       1
---------------------------------------------------------------------------
  222-  252 (42.78/12.36)	QQQQLMAQQNNLSNMHQQQ.....lgpQ......SN.ISGLQQ
  253-  289 (31.20/ 7.23)	QQQQLVGTQSGNSSMQTNQ.....qslHmlsqpkVA.LQQTQQ
  290-  320 (35.32/ 9.05)	TAPNLLPTQGQTSQQPQQQ.....qqlM......SQ.MQSQPT
  362-  397 (30.98/ 7.13)	QQQQLYQSQRAVPETSSTSldstaqtgH......SN.GGDWQE
  498-  525 (33.98/ 8.46)	QQGQLLPTH..MHSMQQPQ.......pE......SNqTQSHDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.96|      23|      25|     448|     470|       2
---------------------------------------------------------------------------
  448-  470 (36.64/31.37)	FKTMLERILSFLTISRA.AIVPAF
  474-  497 (32.33/26.74)	LSSYEDQIGKFIIANRPrKLVSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.28|      28|      29|     603|     630|       3
---------------------------------------------------------------------------
  603-  630 (51.74/34.97)	LPGYEQASSEYHAPDTAGIGVPPIMSIP
  633-  660 (49.54/33.17)	LPGFKEVNDTSGNALTTDFGKPDIAEQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.31|      29|     204|     125|     153|       5
---------------------------------------------------------------------------
  125-  153 (53.09/27.46)	QCSNNLHNPGSQSMQ.SEQVHGEGLSHQNI
  330-  359 (45.22/22.18)	QQPNQVQQNMQQRLQaSGQTSSSLLQSQNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      78.68|      15|     105|     433|     447|       6
---------------------------------------------------------------------------
  433-  446 (17.58/ 6.77)	...LPQQTKSARLEKMK
  530-  541 (21.31/ 9.92)	L..FPSMMRPA...QMP
  542-  554 (21.14/ 9.78)	Q..LKKQM..PRLQQLQ
  555-  571 (18.65/ 7.68)	LlqMLQQRGMHRVDELQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12912 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DCEKETCRETTDHDQETLMNGNNLKPTSASEKPAMGRGDWRT
2) LLPTHMHSMQQPQPESNQTQSHDNQMNPLFPSMMRPAQMPQLKKQM
3) QQLYQSQRAVPETSSTSLDSTAQTGHSNGGDWQEE
4) SQNIVQNSGQCSNNLHNPGSQSMQSEQVHGEGLSHQNIPNDMKGKVNIYDLPG
5) STSVDCADLTMAQQNNHSNMHQQQQQQQQLMAQQNNLSNMHQQQLGPQSNISGLQQQQQQLVGTQSGNSSMQTNQQSLHMLSQPKVALQQTQQTAPNLLPTQGQTSQQPQQQQQLMSQMQSQPTQLRQQLGLQQQPNQVQQNMQQRLQASGQTSSSLLQ
5
502
364
116
197
46
547
398
168
355










Molecular Recognition Features






MoRF SequenceStartStop




NANANA