<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12902

Description mediator of RNA polymerase II transcription subunit 15a-like
SequenceMDTNNWRPTPPSGEPSMDSGDWRTTLQPDSRQRIVNKIMDTLKRHLPFSGQEGLSELRKIAVRFEEKIFTAASSQTDYLRRISLKMLTMETKSQNTMPNTGNNSKPPDPGSQGMQNQVHSQGQSVPIPLQCNQSQAHQQLLPQSVPNNMASAGVQSSVGLQSGMPPVSGLSQNPISNVVGQNSNIQNMSGILQNSMGQGMPSNIFANQQRQMQGRQQVVPQQQQQQLYHQQLQQTLMKQKIQQGNLQPSLLQSHVQQQQQQNLLPPTQLQSSQQSGMLTSSIMQPSAMQSTLPGLQQNQQSSLQQSTQSMLQQHQQSVLRQQQQPQQTTSAGIHQQQTPMTQQSMMPQQQQQQQMMGQQANAANIPQNQLIGQQNSIADMQQQRLLGQSSNLQQQQQQQQLMAQQNNLSNMHQQQLGPQSNISGLQQQQQQLVGTQSGNSSMQTNQQSLHMLSQPKVALQQTQQTAPNLLPTQGQTSQQPQQQQQLMSQMQSQPTQLRQQLGLQQQPNQVQQNMQQRLQASGQTSSSLLQSQNLIDQQKQLYQSQRAVPETSSTSLDSTAQTGHSNGGDWQEEVYQKIKAMKETYFSELNEMHQKISAKLLQHDSFPQQPKSEQLEKLKIFKTMLEPILHFLTVSKANIVPAFKDKLRSYEKQILNCINTNRPRKPVSALQQGQLPPPHMHSMQQPQPQSNQTQSHDNQMNPQLQSINLQGSMPTMQPNNMTSLQHNTLSSLPGVSTAQQTMLNSLQPGSNLDPGQGNALGSMQQVAPGSLQQNPVSTSQQANLNSLSSQSGLSVLQQNMNPLQSNSSMLQHQHMKQQQEQQILQSQKYKQQLQQQRQMQHQIMQQKHQLMQQQQQQAKQQLPTQLQAHQMPQLHQMNDVNDMKQGISVKPGVFQQHLPAGQRQTYTHQQLKSGAQFPISSPQLHPAASPQMPQHSSPQIDQQSLLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPAPGTSSLSNAANIGHQQGTGVQAGSQSLAIGTPGISASPLLAEFTDGTHANVLTTVSSKSNITEQPLERLMKAVKSMSPTALCASVSDIGSVVSMTDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITQDGMSGTKKMRRHTSAMPLNVVSSVGSINDSFKQLTGSETSDLESTATSTVKKPRIEANHALLEEIREINQQLIDTVVDISDEDVDPGTVATAAEGGEGTVVKCSFNAVALSSNLKSQYMSAQMSPIQPLRLLVPTNYPNCSPVLLDKFPVEVSKEYEDLSVKAKSKFSILLRTLSQPMSLGEIARTWDVCARAIISEHAQQSGGGSFSSKYGTWENCSMAA
Length1337
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.03
Grand average of hydropathy-0.756
Instability index75.38
Isoelectric point9.21
Molecular weight147016.28
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12902
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     721.45|      71|      75|     289|     359|       1
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  166-  231 (69.41/11.02)	..PVSGL......SQNPI.....SNVvgQN.SNiQNM...........SGIL...QNSM...GQGMPS..NI..FANQQRQMqGR.QQVVP.......QQQQQQ.L......YHQQ
  289-  359 (137.84/30.10)	QSTLPGL......QQNQQ.....SSL..QQ.ST.QSML...QQH...QQSVLR..QQQQ...PQQTTS..AG..IHQQQTPM.TQ.QSMMP.......QQQQQQQM......MGQQ
  367-  415 (62.03/ 8.96)	QNQLIG.......QQN...............SI.ADMQ...QQRllgQSSNLQ..QQQQ...QQQL...............M.AQ.QNNLS.............NM......HQQQ
  419-  489 (83.06/14.83)	QSNISGL......QQQQQ.....QLV.gTQ.SG.NSSM...QTN...QQS.LH..MLSQ...PK..........VALQQTQQ.TA.PNLLPtqgqtsqQPQQQQQL......MS.Q
  491-  538 (59.69/ 8.31)	QSQPTQL......R..QQ.....LGL..QQ.QP.NQV...................QQN...MQQRL..........QASGQ.TS.SSLL...........QSQNL......IDQQ
  637-  703 (55.08/ 7.02)	ANIVPAF......KDK.....................L...RSY...EKQILNciNTNR...PRKPVS..A...LQQGQLPP.PHmHSMQQ.......PQPQSNQTqshdnqMNPQ
  710-  781 (71.16/11.51)	QGSMPTM......QPNNM.....TSL..QH.NT.LSSLpgvSTA...QQTML...NSLQ...PGSNLD..PG..QGNALGSM....QQVAP.......GSLQQNPV.....sTSQQ
  790-  852 (73.22/12.08)	QSGLSVL......QQNMNplqsnSSM..LQ.H..QHMK...QQQ...EQQILQ..SQKY...KQQL..........QQQRQM.QH.QIM...........QQKHQL......MQ..
  853-  916 (57.92/ 7.81)	..............QQQQ.....QAK..QQlPT.Q..L...QAH...QMPQLH..QMNDvndMKQGISvkPG..VFQQHLPA.GQ.RQTYT.......HQQLKS.........GAQ
  918-  983 (52.03/ 6.17)	PISSPQLhpaaspQMPQH.....SSP..QI.DQ.QSLL...P.......SI.S..KTGT...PLQSAN..SPfvVPSPSTPL.A..PSPMP.......GESEK.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.86|      12|      16|       1|      12|       2
---------------------------------------------------------------------------
    1-   12 (27.55/17.34)	MDTNNWRPT..PPS
   17-   30 (21.31/11.66)	MDSGDWRTTlqPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.53|      15|      16|     107|     121|       3
---------------------------------------------------------------------------
  107-  121 (30.22/14.01)	PDPGSQGMQNQVHSQ
  126-  139 (27.17/11.72)	PIP.LQCNQSQAHQQ
  147-  161 (23.14/ 8.70)	NNMASAGVQSSVGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.19|      25|      26|     233|     257|       4
---------------------------------------------------------------------------
  233-  257 (43.05/16.99)	QQTLMKQKIQQGNLQPSLLQSHVQQ
  260-  284 (43.15/17.05)	QQNLLPPTQLQSSQQSGMLTSSIMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     303.91|      86|      86|     998|    1083|       7
---------------------------------------------------------------------------
  998- 1080 (132.86/73.18)	................GHQQ.GTGVQA..GSQSLAIGTPGISASPLLAEFTDG..........THANV.LTTVSSKSNITEQPLERLMKAVKSMS...PTAL..CAS.VSDIGSVVSMT
 1081- 1165 (91.66/48.07)	DRI............aGSAP.GNGSRAavGEDLVAMTKCRLQARNFITQ..DGmsgtkkmrrhTSAMP.LNVVSSVGSIND........SFKQ........L..TGSeTSDLESTATST
 1169- 1259 (79.38/40.58)	PRIeanhalleeireiNQQLiDTVVDI..SDEDV...DPGTVATA..AEGGEG..........TVVKCsFNAVALSSNLKSQYMSAQMSPIQPLRllvPTNYpnCSP.V..........
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12902 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ILNCINTNRPRKPVSALQQGQLPPPHMHSMQQPQPQSNQTQSHDNQMNPQLQSINLQGSMPTMQPNNMTSLQHNTLSSLPGVSTAQQTMLNSLQPGSNLDPGQGNALGSMQQVAPGSLQQNPVSTSQQANLNSLSSQSGLSVLQQNMNPLQSNSSMLQHQHMKQQQEQQILQSQKYKQQLQQQRQMQHQIMQQKHQLMQQQQQQAKQQLPTQLQAHQMPQLHQMNDVNDMKQGISVKPGVFQQHLPAGQRQTYTHQQLKSGAQFPISSPQLHPAASPQMPQHSSPQIDQQSLLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPAPGTSSLSNAANIGHQQGTGVQAGSQSLA
2) KQLYQSQRAVPETSSTSLDSTAQTGHSNGGDWQEEV
3) MDTNNWRPTPPSGEPSMDSGDWRTTLQPDSRQRIVNKIMDTLKRHLPFSGQEGLSEL
4) QQGNLQPSLLQSHVQQQQQQNLLPPTQLQSSQQSGMLTSSIMQPSAMQSTLPGLQQNQQSSLQQSTQSMLQQHQQSVLRQQQQPQQTTSAGIHQQQTPMTQQSMMPQQQQQQQMMGQQANAANIPQNQLIGQQNSIADMQQQRLLGQSSNLQQQQQQQQLMAQQNNLSNMHQQQLGPQSNISGLQQQQQQLVGTQSGNSSMQTNQQSLHMLSQPKVALQQTQQTAPNLLPTQGQTSQQPQQQQQLMSQMQSQPTQLRQQLGLQQQPNQVQQNMQQRLQASGQTSSSLLQ
5) RRISLKMLTMETKSQNTMPNTGNNSKPPDPGSQGMQNQVHSQGQSVPIPLQCNQSQAHQQLLPQSVPNNMASAGVQSSVGLQSGMPPVSGLSQNPISNVVGQNSNIQNMSGILQNSMGQGMPSNIFANQQRQMQGRQQVVPQQQQ
654
539
1
242
80
1013
574
57
530
224










Molecular Recognition Features






MoRF SequenceStartStop




NANANA