<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12887

Description mediator of RNA polymerase II transcription subunit 15a-like
SequenceMDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSGQEGLNELRKIAVRFEEKIFTAATSQSDYLKRISLKMLTMENKSQGTVPNTGNNSKPPDPGSQGMQNQVHSQGQSIPISLQSNQSQAQLLPPSVPNNMASAGVQSSAGLQSGMPAVSGLTQNPVPNVVGQNTNIQNMSGISQNSLGQGMSSNMFANQQRQMPRQQVLPQQQQQQQQQQQQLYHQQLQNQLMKQKMQQGNLQPSLMQSHMQQQQNLLPPTQLQSSQQSGMQTSSVIQQSSMQSTPLPGLQHNQQSSLQQSSQSMLQQHQQFRQQQQAQQAASSGIHQQQTPMTQQSMMPPQQHQHQPPQPQHQQPHIVGQQANAANSQQNQLIGQQNSIADMQQQRLLGQANSLPNMQQQQQQQQQQQLMAQKNNMPNIHQQQLGPQSNSSGLQQQQQQPHLIGAQSGNSSMQANQQSLHMLPQPKVPLQQTQQSSPNLLPPTQVQTSQQPQQQLMSQMQTQSTLQQQLGLQQQHNMQQRLQASGQVSSSLLQSQNLTEQQKQLYQSQRAVPETSSTSLDSTAQTGLANGGDWQEEVYQKILTLKETYLPELNEMYQKIATKLQQHDSNPAQPKSEQLEKLKIFKTMLERIIGFLTVSRVNITPPFKEKLSSYEKQIINFINSNRPRKPVSVLQQGQLPPPHMHSMQQQQQSQISQTQSHDNQMNPQLQSMNLQGSVPTMQPNNMTSMQHNSLSPGVSTAQQTMLNSLQPGSSLDSGQGNALGPVQQVAPGPLQQNPVSTSQQTNFNSNSLSSQSGLTVLTQNINPLQSNSNMLQHQHMKQQQEQQMLQSQKCKQQFQQRQMQHQCIQQKQQQQQQQQQAKQQLSTHQMSQLHQMNDVNDMRQGMGVKPGVFQHLPAGQRQSYTHQQLKPGSQFPVSSSQLLQAASPQMPQHSSPQVDQQNLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPVLGTSLPNVANLGHQQGTGVQTGSQSLAIGTPGISASPLLAEFSGADGSHANALTAVSSKSNVTEQPLERLIKAVKSISPTALGASVSDIGSVVSMTDRIAGSAPGNGSRAAVGEDLVAMTKCRLQAKNFISQDGMSGTKKIRRYTSAMPLNVVSSAGSLNDSFKQLTGSETSELESTATSSVKRPRIEANHALLEEIREINQRLIDTVVDISDEDVDPGAAAATAKGGEGTIVKCSFSAVALSANLKSQYMSAQMSPIQPLHLLVPTNYPNCSPILLDKFPVEVSKENEDLSVKAKSRFSISLRTLSQPMSLGEIARTWDVCARAVISDHAKLSGGGSFSSKYGTWENCLSAA
Length1342
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.03
Grand average of hydropathy-0.780
Instability index72.75
Isoelectric point9.33
Molecular weight147150.88
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12887
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.47|      29|      32|     299|     327|       1
---------------------------------------------------------------------------
  287-  322 (43.73/10.89)	SSMQStplpglqHNQQSSLQQSSQSML..QQHQQFRQQ
  323-  357 (39.32/ 8.65)	QQAQQ.aassgiHQQQTPMTQ..QSMMppQQHQHQPPQ
  831-  858 (36.43/ 7.17)	QEQQM.......LQSQKCKQQFQQRQM..Q.HQCIQQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     984.34|     124|     185|     170|     298|       2
---------------------------------------------------------------------------
   74-  169 (94.73/17.23)	......................SQS..DY.LKRIS.LKMLTMEN.K.S......................QGTV.............................PNTGNNSKPPDPG...SQGMQNQV...............HS.QG.QSIPISLQSN.QSQ..AQLL.PP.SvpnnmasaGVQSSAglQSGMPAV.....S.............GLT
  170-  298 (227.35/54.88)	QNPV.PNVVG.QNTNIQNMSGISQN..SL.GQGMS.SNMFANQQ.R.QM...................PRQQVL.............................PQQQQQQQQQQQQL.YHQQLQNQLMK.........Q..KMQ.QG.NLQPSLMQSHMQQQ..QNLL.PP.T........QLQSSQ..QSGMQTS.....SVIQQssmqsTPLPGLQ
  359-  442 (130.59/27.41)	QHQQ.PHIVG.QQANAANS...QQN..QLiGQQNSiADM..QQQ.R.LL...................GQANSL.............................PNMQQQQQQQQQQ.........QLMA.........Q..K......NNMPNIHQ....QQ....L........................GPQSN.....S............SGLQ
  444-  498 (73.48/11.20)	QQQQ.PHLIG....................AQSGN.SSMQANQQ.SlHM........................L.............................PQPKVPLQQTQQSS.P..............................................NLL.PP.T........QVQTSQ..Q............................
  499-  576 (70.05/10.23)	....................................................................PQQQLM.............................S.QMQTQSTLQQQL.GLQQQHN..MQ.........Q..RLQaSG.QVSSSLLQS.......QNLTeQQ.K........QLYQSQ..RAVPETSstsldSTAQ.........TGLA
  582-  717 (107.66/20.90)	QEEVyQKILTlKETYLPELNEMYQKiaTK.LQQHD.SNPAQPKS.E.QLeklkifktmleriigfltvSRVNIT.............................PPFKEKLSS......YEKQIINFI..nsnrprkpvS..VLQ.QG.QLPPPHMHSMQQQQ..QSQI.SQ.T........QSHDNQ..MN.......................PQLQ
  722-  809 (123.81/25.49)	QGSV.PTM....QPN..NMTSMQHN..SL.SPGVS.TA....QQ.T.ML...................NSLQ...............................PGSSLDSGQG...........NALGP........vQ..QVA.PG.PL...........Q..QN...P............VSTSQ..QTNFNSN.....SLSSQ.....SGLTVLT
  810-  910 (61.42/ 7.78)	QNIN.P..LQ.SNSN.......................MLQHQHmK.Q..........................qqeqqmlqsqkckqqfqqrqmqhqciqqkQQQQQQQQQAKQQLsTHQMSQLHQMN.........DvnDMR.QGmGVKPGVFQ.H.........L.PA.G........QRQS.................................
  914- 1012 (95.23/17.37)	................QQLKPGSQF..PV.S...S.SQLLQAAS.P.QM...................P.QHSS.............................PQVDQQNLPSISKTgTPLQSANSPFV.........V..PSP.ST.PLAPSPMPGESEKPvlGTSL.PNvA........NLGHQQ..GTGVQTG.....S................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     403.15|     116|     120|    1023|    1140|       3
---------------------------------------------------------------------------
 1023- 1115 (125.27/81.51)	............................SASPLLAEFSGADGSHANAL..TAVSS.KSNVTEQPlERLIKAVKSIS.PTALG..ASVSDIGSVVSMTDRIAGSAPGNGSRAAVGEDlVAMTKCRLQA
 1116- 1228 (156.22/93.96)	KNFISQDGMSGTKKIRRYTSAMPLNvvsSAGSLNDSFKQLTGSETSELesTATSSvKRPRIEAN.HALLEEIREIN.QR.L........IDTVVDISDE..DVDPGAAAATAKGGE.GTIVKCSFSA
 1233- 1327 (121.66/71.17)	ANLKSQYMSAQMSPIQPLHLLVPTN.ypNCSPILLDKFPVEVSKENED..LSVKA.KS........RFSISLRTLSqPMSLGeiARTWDVCARAVISDHAKLS..GGGS..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.14|      12|      15|       1|      12|       4
---------------------------------------------------------------------------
    1-   12 (26.56/16.33)	MDTNNWRS..TPPS
   17-   30 (21.58/11.75)	MDTGDWRTqlQPDS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12887 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPVSVLQQGQLPPPHMHSMQQQQQSQISQTQSHDNQMNPQLQSMNLQGSVPTMQPNNMTSMQHNSLSPGVSTAQQTMLNSLQPGSSLDSGQGNALGPVQQVAPGPLQQNPVSTSQQTNFNSNSLSSQSGLTVLTQNINPLQSNSNMLQHQHMKQQQEQQMLQSQKCKQ
2) KRISLKMLTMENKSQGTVPNTGNNSKPPDPGSQGMQNQVHSQGQSIPISLQSNQSQAQLLPPSVPNNMASAGVQSSAGLQSGMPAVSGLTQNPVPNVVGQNTNIQNMSGISQNSLGQGMSSNMFANQQRQMPRQQVLPQQQQQQQQQQQQLYHQQLQNQLMKQKMQQGNLQPSLMQSHMQQQQNLLPPTQLQSSQQSGMQTSSVIQQSSMQSTPLPGLQHNQQSSLQQSSQSMLQQHQQFRQQQQAQQAASSGIHQQQTPMTQQSMMPPQQHQHQPPQPQHQQPHIVGQQANAANSQQNQLIGQQNSIADMQQQRLLGQANSLPNMQQQQQQQQQQQLMAQKNNMPNIHQQQLGPQSNSSGLQQQQQQPHLIGAQSGNSSMQANQQSLHMLPQPKVPLQQTQQSSPNLLPPTQVQTSQQPQQQLMSQMQTQSTLQQQLGLQQQHNMQQRLQASGQVSSSLLQ
3) MDTNNWRSTPPSGEPTMDTGDWRTQLQPDSRQRIVNKIMDTLKRHLPFSGQEGLNEL
4) QRQMQHQCIQQKQQQQQQQQQAKQQLSTHQMSQLHQMNDVNDMRQGMGVKPGVFQHLPAGQRQSYTHQQLKPGSQFPVSSSQLLQAASPQMPQHSSPQVDQQNLPSISKTGTPLQSANSPFVVPSPSTPLAPSPMPGESEKPVLGTSLPNVANLGHQQGTGVQTGSQSLAI
676
80
1
847
843
541
57
1017










Molecular Recognition Features






MoRF SequenceStartStop




1) KKIRRY
1128
1133